Protein Alignment PIP4K2C and sktl

DIOPT Version :9

• Sequence 1: NP_001139730.1
• Gene: PIP4K2C / 79837
• HGNCID: 23786
• Length: 421
• Species: Homo sapiens
• Sequence 2: NP_001286646.1
• Gene: sktl / 37356
• FlyBaseID: FBgn0016984
• Length: 792
• Species: Drosophila melanogaster
• Alignment Length: 482
• Identity: 128/482 - (26%)
• Similarity: 216/482 - (44%)
• Gaps: 84/482 - (17%)

Human     1 MASSSVPPATVSAATA------GPGPGFGFASKTKKKHFVQQKVKVFRAAD------------PL 47
            :|::..|.:.:.:|::      ...|     |.|..||  ::|:...|.|:            .:
  Fly   102 IAATQTPASKLRSASSTLDASISRNP-----STTGGKH--EKKLGHRRVAEGGEVTYKKIQSKQI 159

Human    48 VGVFLWGVAHSINELSQVPPPVMLLPDDFKA--------SSKIKVNNHLFHRENLPSHFKFKEYC 104
            :|....|:.|::..|:..|...:|:.|.::.        .|.|...:|.       :.|:||.|.
  Fly   160 MGSIQLGIQHTVGSLASKPKRDLLMNDFWEMETISFPPDGSSITPAHHY-------NDFRFKVYA 217

Human   105 PQVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSEDIADMHSNL 166
            |..||..||.|||...|:|:|:..:|..|  :.|:.|. |.::.|...:||.|..::...:...|
  Fly   218 PIAFRYFRDLFGIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLL 282

Human   167 SNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDK 231
            ..|:..:.: :..||||:|.|:|....::::..::.|.|:....:.:|.|||||||...|:||..
  Fly   283 PGYYMNLSQ-NPRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKA 346

Human   232 EKVKELPTLKDMDFLNKNQK-VYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDI-IRGS 294
            |:.|..||.||:||...:.. :::..::....:..:|||...|...:|||||||:|||:: :...
  Fly   347 ERQKASPTFKDLDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAK 411

Human   295 EPEEE------APVREDESEVDGDCSLT----GPPA------LVGSYGTSP-EGIGGYIHSHRPL 342
            |..||      |.::..||...|..||.    .|.|      .|.||.:.| ...|..::..|.:
  Fly   412 EKREERILNARAKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSM 476

Human   343 G--------------------PGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAH 387
            .                    |.|.:..:....|.:.....::.:.::|:||||..|..:||..|
  Fly   477 NRQRLVAHSTALESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEH 541

Human   388 AAKTVKHGAGAEISTVHPEQYAKRFLD 414
            ..|::.:. |..:|...|..|||||.|
  Fly   542 TFKSILYN-GDTVSVCRPSFYAKRFQD 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K2C	NP_001139730.1	Required for interaction with PIP5K1A. /evidence=ECO:0000269|PubMed:31091439	69..75		1/5 (20%)
		PIPKc	72..420	CDD:214623	111/393 (28%)
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	112/394 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820