DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LONRF3 and lonrf3

DIOPT Version :9

Sequence 1:	XP_005262533.1	Gene:	LONRF3 / 79836	HGNCID:	21152	Length:	811	Species:	Homo sapiens
Sequence 2:	XP_002934588.3	Gene:	lonrf3 / 100486178	XenbaseID:	XB-GENE-985290	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	805	Identity:	403/805 - (50%)
Similarity:	524/805 - (65%)	Gaps:	79/805 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    16 VSSDNLESAERGASAAQVDMGPHPKVAAEGPAPLPTREPEQEQSPGTSTPESKVLLTQADALASR 80
            :||...:|:.....|||.....:.::|:|    :..|: .|||..|  ..:..:||.:||.||..
Frog     1 MSSQEADSSLMLEFAAQAFQAKNFQLASE----IYERQ-LQEQKAG--VVDWGLLLKRADCLACS 58

Human    81 GRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQGEALAPAPPDEGSTASGTVAAEETGAAA 145
            ||:::|.:::::.:..:::.||.||.||.|||:.:...|.|  .|||:             ..|.
Frog    59 GRLQDACDLFQRAAMHKKVCAEDLEALVSCLADHIRTKEGL--PPPDQ-------------RVAK 108

Human   146 AAAATEVWDGFKCRKCHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLSALMVATGRAR 210
            :|..|       ||:|.||..:||:|.|||||||.|||....:...|.:|.|...
Frog   109 SAVLT-------CRQCQGFFFEPVTLLCGHTFCKKCLECQGGSKSECKVCRVSTE---------- 156

Human   211 GARRAGQQPPPPLRVNVVLSGLLGKLFPGPARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPN 275
                      .|.||||:||.:|.|.||...:|.:||.|||.||::.:.|.||.:||||:.:||.
Frog   157 ----------HPFRVNVLLSNILSKWFPSQVKAVRLRQEGNALYKDCKWEEALARYNEAISIAPQ 211

Human   276 DHLLYSNRSQIYFTLESHENALHDAEIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSL 340
            ||||||||:.|:|:|:|:..||.|||..|||:|...|.|.||||:|..||:.|::|:|||:|::|
Frog   212 DHLLYSNRAMIHFSLKSYGCALQDAETTCKLQPYWLKGHLRKAQSLVNLGRSEDSLKEFLFCLAL 276

Human   341 DGKNKRARCEAQRLLLSFFSPSVPGDSQEHSPDILKLLAPHP-RLKENV-ESMTTEVTSHNLPRL 403
            :.:|:.|:||||:|||:..|..   ::|...|:||:.:: || |||.|| .|::|...|.|:.||
Frog   277 ETENRTAKCEAQKLLLNLLSLQ---NNQGDLPEILQTMS-HPLRLKGNVLNSLSTPTPSSNMQRL 337

Human   404 LQDNLELPHCSSQEEAAARGDGSSLMDPAKVKGDGQQHHMKDQEEEE----EKWDATSPKAASSK 464
            ...|:::.            .|.::.|....||:.....:....|.|    |...|.:|:.|:..
Frog   338 KMVNMDIK------------KGVTISDDTDPKGNSSMWLLHQTRESELSCSEMTKAFTPEPAALV 390

Human   465 TGKCQEKKRKHCQIESQ-EETGMPNKASKQDPP---TDQGDKPALSLPLASFDASDLECALCMRL 525
            ...|...|||.|..|:: ....:|.||.|:|..   |...|..:.|    ..|.|||:|:|||||
Frog   391 PSACNTLKRKACSKETECSSEHIPCKALKRDAAVTGTLGNDHSSAS----CVDLSDLDCSLCMRL 451

Human   526 FYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLSQCLASRKYSKNVIMEELIAKFLPEELKER 590
            .|||||||||||:||||||||||||.||||||:.|.:.||.|.:.|..:||:|||.:.|:|||:|
Frog   452 LYEPVTTPCGHTYCLKCLERCLDHNPKCPLCKEDLCEYLAIRTFCKTELMEDLIASYFPDELKDR 516

Human   591 RKLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGDPVK 655
            :.:||||:.|||||||||||||||||||||||||||||||||||||||:||||:|||||:||.||
Frog   517 KTVYEEEIAELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCMETGTKQFGMCIGDSVK 581

Human   656 GFAEYGCILEIRNVQFFADGRSVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQGEDCAELM 720
            |||:|||:||||||:|||||||||||||||||:|:..||||||||||||||||.|.||::..:|:
Frog   582 GFADYGCMLEIRNVEFFADGRSVVDSIGKRRFKVIRHSQRDGYNTADIEYIEDHKAQGQEYDDLL 646

Human   721 GLHNCVYQQASLWFHSLKLSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWMLAVLPLESRAQLP 785
            .|||.||.||..||.:||.:||:|||:||||||..|.|.|.||||||||||:|||||||||||||
Frog   647 TLHNAVYDQAFNWFSTLKPALKSRILSHFGPMPANDCDIQANPNGPAWCWWILAVLPLESRAQLP 711

Human   786 FLAMRSLKDRLNGIRRVLAFISRNQ 810
            ||||.||||||.||||||.|:.|::
Frog   712 FLAMTSLKDRLTGIRRVLLFMCRSR 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LONRF3	XP_005262533.1	RING	158..195	CDD:302633	19/36 (53%)
		TPR_11	242..308	CDD:290150	37/65 (57%)
		TPR repeat	243..271	CDD:276809	15/27 (56%)
		TPR repeat	276..306	CDD:276809	18/29 (62%)
		TPR repeat	311..334	CDD:276809	11/22 (50%)
		RING	518..557	CDD:238093	33/38 (87%)
		LON_substr_bdg	607..808	CDD:280370	160/200 (80%)
		LON	618..796	CDD:271862	140/177 (79%)
lonrf3	XP_002934588.3	RING1-HC_LONFs	114..152	CDD:319427	19/37 (51%)
		3a0801s09	<179..>270	CDD:273380	49/90 (54%)
		TPR repeat	179..207	CDD:276809	15/27 (56%)
		TPR repeat	212..242	CDD:276809	18/29 (62%)
		TPR repeat	247..270	CDD:276809	11/22 (50%)
		RING2-HC_LONFs	442..483	CDD:319428	35/40 (88%)
		LON_substr_bdg	533..734	CDD:396663	160/200 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	331	1.000	Domainoid score	I8103
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11712
Inparanoid	1	1.050	705	1.000	Inparanoid score	I5303
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44865
OrthoDB	1	1.010	-	-		D207900at33208
OrthoFinder	1	1.000	-	-		FOG0001000
OrthoInspector	1	1.000	-	-		oto158314
Panther	1	1.100	-	-	LDO	PTHR23327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X746
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.080