DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLMP and dpr2

DIOPT Version :9

Sequence 1:	NP_079045.1	Gene:	CLMP / 79827	HGNCID:	24039	Length:	373	Species:	Homo sapiens
Sequence 2:	NP_001014480.4	Gene:	dpr2 / 3346227	FlyBaseID:	FBgn0261871	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	67/358 - (18%)
Similarity:	116/358 - (32%)	Gaps:	125/358 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    18 GTHTEIKRVAE----EKVTLPCH-HQLGLPEKDTLDIEWLL-----TDNEGNQKV---------- 62
            |...:.:|.||    |:.|.|.. ...|:|...|.......     .||.|::.|
  Fly    84 GNSIDDEREAEEQPPEETTYPPPVFDFGMPRNITTRTGHTAAINCRVDNLGDKSVSWIRKRDLHI 148

Human    63 ----VITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSH 123
                ::||         |.:::.:|...::  :.|.:|.::..:|.|.|.|.|:| |:...:...
  Fly   149 LTAGILTY---------TSDERFKVVRTAD--SKDWTLHVKYAQPRDSGIYECQV-NTEPKISMA 201

Human   124 VILKVLVRPSKPKCELEGE----LTEGSDLTLQCE------SSSGTEPIVYYWQR---------- 168
            ..|.|:|.|...|..:.|.    :..||.:||.|.      |:....||  ||.|
  Fly   202 FRLNVIVTPPDAKAIIAGPTDLYVKVGSSVTLTCHVKQPATSAQDIGPI--YWYRGPYILTPFVA 264

Human   169 -IREKEGEDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQSIG 232
             ..:...:.:|:..:|.:......|:.:.|..:..:|.|.|                   :.:..
  Fly   265 HPNDAAIDLQRISMESTLAEKLQSRLRIANAQLLDTGNYTC-------------------MPTTA 310

Human   233 MVAGAVTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEIREDAEAPKARLVKPSSSSSGSR-- 295
            ..|..|..::                       .:|.|      |...|:|.::.|.|...||
  Fly   311 EAASVVVNVI-----------------------NDESP------AAMQKSRAIRTSGSMRSSRLV 346

Human   296 ----------------SSRSGSSSTRSTANSAS 312
                            ..|.||:|...:.::.|
  Fly   347 LLLAMVASSVVRWLIGGQRIGSNSCHDSCSNLS 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLMP	NP_079045.1	IgV_CAR_like	13..127	CDD:409552	27/132 (20%)
		Ig strand B	31..35	CDD:409552	1/3 (33%)
		Ig strand C	48..52	CDD:409552	0/3 (0%)
		Ig strand E	94..98	CDD:409552	1/3 (33%)
		Ig strand F	108..113	CDD:409552	2/4 (50%)
		Ig strand G	121..124	CDD:409552	0/2 (0%)
		IG	144..225	CDD:214652	18/97 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..373		14/67 (21%)
dpr2	NP_001014480.4	IG_like	113..206	CDD:214653	20/104 (19%)
		Ig	116..192	CDD:299845	16/86 (19%)
		ig	220..306	CDD:278476	18/106 (17%)
		IG_like	220..306	CDD:214653	18/106 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910