DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLMP and DIP-beta

DIOPT Version :9

Sequence 1:NP_079045.1 Gene:CLMP / 79827 HGNCID:24039 Length:373 Species:Homo sapiens
Sequence 2:NP_001138225.1 Gene:DIP-beta / 33125 FlyBaseID:FBgn0259245 Length:555 Species:Drosophila melanogaster


Alignment Length:437 Identity:100/437 - (22%)
Similarity:153/437 - (35%) Gaps:136/437 - (31%)


- Green bases have known domain annotations that are detailed below.


Human     3 LLLLLLL-------VSYYVGTLGTHTEIKRVAEEKVTL--------PC-------HHQLGLPEKD 45
            |||||||       ||..:.::|.......:..|.||:        .|       |...|.....
  Fly    72 LLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSA 136

Human    46 TLDIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYT 110
            ...:.|:..|    .|.::......:.||      .|::...|.. ...:|.|..:|..|.|:|.
  Fly   137 PAKVAWIKAD----AKAILAIHEHVITNN------DRLSVQHNDY-NTWTLNIRGVKMEDAGKYM 190

Human   111 CKVKNSGRYVWSHVILKVLVRPSKPKCELEGEL--TEGSDLTLQCESSSGTEPIVYYWQR----- 168
            |:| |:.........|:|::.|.....|..|::  .||....|.|.:....:|.: .|:|     
  Fly   191 CQV-NTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKI-TWRREDGRE 253

Human   169 IREKEGEDERLPPKSRIDYNHPGRVL-LQNLTMSYSGLYQCTAGNEAGKESCV---VRVTVQY-- 227
            |..:.|..::...:|     ..|.:| |..:|.|..|.|.|.|.|  |....|   :::.|.:  
  Fly   254 IIARNGSHQKTKAQS-----VEGEMLTLSKITRSEMGAYMCIASN--GVPPTVSKRMKLQVHFHP 311

Human   228 -VQSIGMVAGA-----VT---------------------GIVAG---ALL-----IFLLVWLL-I 256
             ||....:.||     ||                     .|:||   ||.     ::.:..:| |
  Fly   312 LVQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHI 376

Human   257 RR-----------------KDKE---RYEEEERPNE--IRED--AEAPKARLV-KPSSSSSGSRS 296
            :|                 .|.|   |..|.|||.:  :|:|  .|..|..:| |.:.|..|||:
  Fly   377 KRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRN 441

Human   297 SRSGSSSTRSTANSASRSQRTLSTDAAPQPGLATQAYSLVGPEVRGS 343
            ...                 .|..|.||....|:.:..|:|   ||:
  Fly   442 LNG-----------------RLYKDRAPDQHPASGSDQLLG---RGT 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLMPNP_079045.1 IgV_CAR_like 13..127 CDD:409552 23/128 (18%)
Ig strand B 31..35 CDD:409552 2/11 (18%)
Ig strand C 48..52 CDD:409552 0/3 (0%)
Ig strand E 94..98 CDD:409552 1/3 (33%)
Ig strand F 108..113 CDD:409552 2/4 (50%)
Ig strand G 121..124 CDD:409552 0/2 (0%)
IG 144..225 CDD:214652 22/89 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..373 23/85 (27%)
DIP-betaNP_001138225.1 I-set 98..209 CDD:254352 24/122 (20%)
ig 102..195 CDD:278476 21/104 (20%)
IG_like 219..307 CDD:214653 23/95 (24%)
Ig 221..307 CDD:299845 22/93 (24%)
Ig 311..404 CDD:299845 16/92 (17%)
IG_like 327..405 CDD:214653 13/77 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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