DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGAP28 and cv-c

DIOPT Version :9

Sequence 1:NP_001353159.1 Gene:ARHGAP28 / 79822 HGNCID:25509 Length:729 Species:Homo sapiens
Sequence 2:NP_001097786.1 Gene:cv-c / 41749 FlyBaseID:FBgn0285955 Length:2351 Species:Drosophila melanogaster


Alignment Length:716 Identity:152/716 - (21%)
Similarity:262/716 - (36%) Gaps:202/716 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    60 HPPAFSRSNSEASVDSASMEDFWREIESIKD-SSMG--GQEEPPP------AEVTPVDEGELEAE 115
            |.|...:...|:..::.::.:.|.....|:. |.:|  |.|.|||      .|.|.....|...:
  Fly  1446 HKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPPPGLLSLNVEKTESSSKESSPD 1510

Human   116 WLQDVGLS-TLI------SGDEEEDGKAL------------LSTLTRTQAAAVQKRYHTYTQTMR 161
            ..::.|.. ||:      :|....||.:|            .|...:.||.|:.:|..:.....|
  Fly  1511 RFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSGRLRRSGSERIKDQAKALLRRVESIKSRRR 1575

Human   162 KK--------------------DKQSIRDVRDIFGVSESP----PRDT------CGN------HT 190
            |:                    .:.|:|....::....||    |..|      .||      |:
  Fly  1576 KRQNRENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPPSPSALSPMHTFPKAPFFGNDLKVPSHS 1640

Human   191 NQL-----DGTKEERELPRVIKTSG----SMP---------DDASLNSTTLSDASQDKEGSFAVP 237
            :..     ...|.....||.::||.    |.|         ||   :|:..||:.:...|.....
  Fly  1641 DNFLSPNRSSPKRTPTTPRSMRTSPLHFFSSPMSQLKEGKSDD---SSSYYSDSQESSTGGKLSL 1702

Human   238 RSDSVA--ILE---TIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVT 297
            |..|.|  .|:   .:..:..||:.....|:             |.:..:|...:.||...:: |
  Fly  1703 RKPSKARRFLQRTGKVDDIGAHSDSECHQGR-------------KLLIKDANSNTTEVKVKKL-T 1753

Human   298 EALKRNKLKKSEIKKEDYVLTKF-----------NVQKTRFGLTEAGD----------------- 334
            .....| |.|...|::.:..:.|           |.:.|....|..|.                 
  Fly  1754 RGGSLN-LGKDPKKRDGFRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERP 1817

Human   335 --------------------------LSAEDMKKIRHLSLIELTAFFDAF------GIQLKRNK- 366
                                      :||..::.||.|:|:.||...:.:      |...:..| 
  Fly  1818 NMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKF 1882

Human   367 TEKVK---GRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAK 428
            .:|:|   .:|..:|||||.::|     :..|..:||.::..|..::.:.|:..||||.||..::
  Fly  1883 IKKIKMPDYKDKKVFGVPLLMIL-----QRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSR 1942

Human   429 VKQYREELDAKFNA----DKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHV 489
            :.:.||:::...:.    |.|  |.....:.|.|||.:|||||.||...:....|:::.:..| .
  Fly  1943 IMKLREQIEVTDSTAECMDVF--DLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLP-A 2004

Human   490 KVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFS-------- 546
            :|:..|:...|:.|||.||:....|:.|...|.||..:|:|:..|:...:|.::|.|        
  Fly  2005 EVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSAS 2069

Human   547 -------RSKHS---DYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQL 601
                   :.|.|   |.:||..|..:...:..|:::.|.::....   .::.:.|.:.|...|.|
  Fly  2070 VSASPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAK---EKLSKCNFSYMEESKPL 2131

Human   602 P 602
            |
  Fly  2132 P 2132

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGAP28NP_001353159.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..42
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..105 13/53 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..236 20/93 (22%)
RhoGAP_ARHGAP18 377..588 CDD:239856 62/232 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..631
cv-cNP_001097786.1 SAM_DLC1,2-like 1382..1441 CDD:188937
RhoGAP_DLC1 1893..2116 CDD:239840 63/233 (27%)
SRPBCC 2148..2343 CDD:301327
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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