Protein Alignment EHMT1 and Ehmt1

DIOPT Version :10

• Sequence 1: XP_011517323.1
• Gene: EHMT1 / 79813
• HGNCID: 24650
• Length: 1301
• Species: Homo sapiens
• Sequence 2: XP_006498485.1
• Gene: Ehmt1 / 77683
• MGIID: 1924933
• Length: 1312
• Species: Mus musculus
• Alignment Length: 1295
• Identity: 1146/1295 - (88%)
• Similarity: 1203/1295 - (92%)
• Gaps: 9/1295 - (0%)

Human    11 AVPARGEPQQDCCVKTELL--GEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAA 73
            ||.|:.|.:||||:|||||  |::|||||||||.|||.||..||||||||||||.|...||.||.
Mouse    23 AVLAKQETKQDCCMKTELLREGKDTPMAADEGSTEKQEGETPMAADGETNGSCEKSGDPSHLNAP 87

Human    74 KHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQ 138
            ||||::.|.:||:|||.::|:|||||||||:|..||||||||||:||||||||||.|||||||.|
Mouse    88 KHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQ 152

Human   139 PLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKV 203
            ||||.:.|.|||||||||||||||.|.||.||.||||...|...|||||||||||..|.|.||:|
Mouse   153 PLRTPNILTSSLPGHAAKTLPGGASKCRTLSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRV 217

Human   204 HRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC 268
            ||||||||||::||||||||.|||   :|||||||:||:|||:.|||||||.||:||||||||||
Mouse   218 HRARKTMPKSILGLHAASKDHREV---QDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQC 279

Human   269 YMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEK 333
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Mouse   280 YMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEK 344

Human   334 DLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGES 398
            .|..|:||||||||||||:::||:|||:|:.|||||||||||||||||||||||.|||.||||:|
Mouse   345 ALDDSALHVNGESLEMDSEDEDSDELEDDEDHGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDS 409

Human   399 EEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSES 463
            ||||||.||||:|:||||||||||||||||||||:|||||||||||||||||||||||..||||:
Mouse   410 EEEQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEA 474

Human   464 YKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQA--EGLANGPDVLETDGLQEVPLCSCR 526
            .|||.||.||.|.|||.||||||||||||||:||||||.  ||||:|||||.|||||||||||||
Mouse   475 CKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLASGPDVLGTDGLQEVPLCSCR 539

Human   527 METPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCC 591
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   540 METPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCC 604

Human   592 PGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTP 656
            |||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||.
Mouse   605 PGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEEASKAKEVTIAKADTTSTVTL 669

Human   657 VPGQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKE 721
            .|||||..|.||||||||||.||.|  ||::.|..|...||.|||.|||||.|||.|||||||||
Mouse   670 APGQEKSLAAEGRADTTTGSIAGAP--EDERSQSTAPQAPECFDPAGPAGLVRPTSGLSQGPGKE 732

Human   722 TLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 786
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||
Mouse   733 TLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEA 797

Human   787 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAK 851
            ||||||||||||||||||||||||||||||||||||:||||||||||.|||||||||||||||||
Mouse   798 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAK 862

Human   852 KGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWA 916
            ||||:|||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   863 KGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEENICLHWA 927

Human   917 AFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQC 981
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   928 AFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQC 992

Human   982 ASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQ 1046
            |||:|||||||||||||:|||||:|..||:.|||||||||||||||||||||||.||:|||||||
Mouse   993 ASLSSQVWSALQMSKALRDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQ 1057

Human  1047 NCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHA 1111
            |||||||||||||||||||||:||||||.||||||||||||||||||||||||||||||||||||
Mouse  1058 NCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHA 1122

Human  1112 CSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSY 1176
            |||||||||||||||||||||||||:|||||||||||||.|||||||||||||||||||||||||
Mouse  1123 CSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSY 1187

Human  1177 LFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQL 1241
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||:|||||
Mouse  1188 LFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQL 1252

Human  1242 GFDYGERFWDIKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL 1301
            ||||||||||:|||||||||||.|||||||||||||||||||.||:||||||||||||||
Mouse  1253 GFDYGERFWDVKGKLFSCRCGSSKCRHSSAALAQRQASAAQEPQENGLPDTSSAAAADPL 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHMT1	XP_011517323.1	EHMT_ZBD	517..647	CDD:411018	127/129 (98%)
		ANKYR	723..979	CDD:440430	250/255 (98%)
		ANK repeat	745..771	CDD:293786	25/25 (100%)
		ANK repeat	777..806	CDD:293786	28/28 (100%)
		ANK repeat	808..839	CDD:293786	28/30 (93%)
		ANK repeat	841..873	CDD:293786	30/31 (97%)
		ANK repeat	875..906	CDD:293786	29/30 (97%)
		ANK repeat	908..939	CDD:293786	30/30 (100%)
		ANK repeat	941..972	CDD:293786	30/30 (100%)
		SET_EHMT1	1039..1269	CDD:380933	220/229 (96%)
Ehmt1	XP_006498485.1	EHMT_ZBD	530..660	CDD:411018	127/129 (98%)
		ANKYR	734..990	CDD:440430	250/255 (98%)
		ANK repeat	788..817	CDD:293786	28/28 (100%)
		ANK repeat	819..850	CDD:293786	28/30 (93%)
		ANK repeat	852..884	CDD:293786	30/31 (97%)
		ANK repeat	886..917	CDD:293786	29/30 (97%)
		ANK repeat	919..950	CDD:293786	30/30 (100%)
		ANK repeat	952..983	CDD:293786	30/30 (100%)
		SET_EHMT1	1050..1280	CDD:380933	220/229 (96%)