Protein Alignment EHMT1 and Ehmt1

DIOPT Version :10

• Sequence 1: XP_011517323.1
• Gene: EHMT1 / 79813
• HGNCID: 24650
• Length: 1301
• Species: Homo sapiens
• Sequence 2: XP_006233681.2
• Gene: Ehmt1 / 362078
• RGDID: 1307588
• Length: 1309
• Species: Rattus norvegicus
• Alignment Length: 1293
• Identity: 1152/1293 - (89%)
• Similarity: 1203/1293 - (93%)
• Gaps: 7/1293 - (0%)

Human    11 AVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKH 75
            ||.|:.|.:||||:|||||.|:|.|||||||.||||||..||||||||||||.|...||.||.||
  Rat    22 AVLAKQETKQDCCMKTELLREDTLMAADEGSTEKQAGETPMAADGETNGSCEKSGDISHPNAPKH 86

Human    76 TQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPL 140
            ||::.|.:||:|||.::|:|||||||||:|..||||||||||:||||||||||.|||||||.|||
  Rat    87 TQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPL 151

Human   141 RTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHR 205
            ||.:||.|||||||||||||||.|.|||||.||||...|...|||||||||||..|.|.||:|||
  Rat   152 RTPNTLNSSLPGHAAKTLPGGASKCRTPSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHR 216

Human   206 ARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYM 270
            ||||||||::||||||||.|||   :|||||||:||:|||:.|||||||.||:||||||||||||
  Rat   217 ARKTMPKSILGLHAASKDHREV---QDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYM 278

Human   271 ATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDL 335
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||.|
  Rat   279 ATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKVL 343

Human   336 GASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEE 400
            ..|:||||||||||||:|:||||||:::..||||||||||||||||||||||.|||.||||:|||
  Rat   344 DDSALHVNGESLEMDSEEEDSEELEDEEDRGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEE 408

Human   401 EQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYK 465
            ||||.||||:|:||||||||||||||||||||:|||||||||||||||||||||||..||||:.|
  Rat   409 EQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACK 473

Human   466 SSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQA--EGLANGPDVLETDGLQEVPLCSCRME 528
            ||.||.||.|.|||.||||||||||||||:||||||.  |||||||||||||||.||||||||||
  Rat   474 SSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLANGPDVLETDGLHEVPLCSCRME 538

Human   529 TPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPG 593
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   539 TPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPG 603

Human   594 CGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVP 658
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||..|
  Rat   604 CGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEETSKAKEVTIAKADTTSTVTLAP 668

Human   659 GQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL 723
            ||||..|.||||||||||.||.|  ||:|.|...:..||.|||.||||..|||.|.|||||||||
  Rat   669 GQEKSLAAEGRADTTTGSIAGAP--EDEKSQSTVTQAPECFDPAGPAGFVRPTSGFSQGPGKETL 731

Human   724 ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGH 788
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
  Rat   732 ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGH 796

Human   789 VDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKG 853
            ||||||||||||||||||||||||||||||||||:||||||||||.|||||||||||||||||||
  Rat   797 VDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKG 861

Human   854 HYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF 918
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   862 HYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF 926

Human   919 SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 983
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   927 SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 991

Human   984 LNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNC 1048
            |||||||||||||||||||||:|..||:.|||||||||||||||||||||||.||:|||||||||
  Rat   992 LNSQVWSALQMSKALQDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNC 1056

Human  1049 VTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACS 1113
            |||||||||||||||||||:||||||.||||||||||||||||||||||||||||||||||||||
  Rat  1057 VTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACS 1121

Human  1114 CWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLF 1178
            |||||||||||||||||||||||:|||||||||||||.|||||||||||||||||||||||||||
  Rat  1122 CWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLF 1186

Human  1179 DLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGF 1243
            |||||||||||||||||||||||||||||||||||||||:|||||||||||||||||:|||||||
  Rat  1187 DLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGF 1251

Human  1244 DYGERFWDIKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL 1301
            ||||||||:||||||||||||||||||||||||||||||||||:||||||||||||||
  Rat  1252 DYGERFWDVKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQENGLPDTSSAAAADPL 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHMT1	XP_011517323.1	EHMT_ZBD	517..647	CDD:411018	126/129 (98%)
		ANKYR	723..979	CDD:440430	251/255 (98%)
		ANK repeat	745..771	CDD:293786	25/25 (100%)
		ANK repeat	777..806	CDD:293786	28/28 (100%)
		ANK repeat	808..839	CDD:293786	28/30 (93%)
		ANK repeat	841..873	CDD:293786	30/31 (97%)
		ANK repeat	875..906	CDD:293786	30/30 (100%)
		ANK repeat	908..939	CDD:293786	30/30 (100%)
		ANK repeat	941..972	CDD:293786	30/30 (100%)
		SET_EHMT1	1039..1269	CDD:380933	221/229 (97%)
Ehmt1	XP_006233681.2	EHMT_ZBD	527..657	CDD:411018	126/129 (98%)
		ANKYR	731..987	CDD:440430	251/255 (98%)
		ANK repeat	785..814	CDD:293786	28/28 (100%)
		ANK repeat	816..847	CDD:293786	28/30 (93%)
		ANK repeat	849..881	CDD:293786	30/31 (97%)
		ANK repeat	883..914	CDD:293786	30/30 (100%)
		ANK repeat	916..947	CDD:293786	30/30 (100%)
		ANK repeat	949..980	CDD:293786	30/30 (100%)
		SET_EHMT1	1047..1277	CDD:380933	221/229 (97%)