Protein Alignment EHMT1 and Set2

DIOPT Version :10

• Sequence 1: XP_011517323.1
• Gene: EHMT1 / 79813
• HGNCID: 24650
• Length: 1301
• Species: Homo sapiens
• Sequence 2: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Alignment Length: 1472
• Identity: 295/1472 - (20%)
• Similarity: 478/1472 - (32%)
• Gaps: 464/1472 - (31%)

Human    11 AVPARGEPQQDCCV--------KTELLG--------EET--PMAAD------EGSAEKQAGEAHM 51
            |.|...||..|.|.        ...|.|        |||  .:||:      |....:...|.|:
  Fly   403 ATPPGKEPAADSCSSAPRRSRRSAPLSGSSRQGKTLEETFAEIAAESSKQILEAEESQDQEEQHI 467

Human    52 AADGETNGSCENSDASSHANAAKH-------TQDSARVNPQDG--TNTLTRIAENGVSERDSEAA 107
            ..|...:...|:...||.:...:|       .:::..|:..|.  .:....:.:...||.|:.||
  Fly   468 LIDLIEDTLSESEVTSSVSPTIEHMVVEEVVVEENQLVDEADEILDSKQEFVIKKVFSESDNIAA 532

Human   108 KQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRT----- 167
            ..|....:..|:|.  .:.|.::.:|.:..:.:..|..:|::|...|..|.|.......|
  Fly   533 SLNKDIFEPKVETK--ATCGEVVPRPEMVTEDVYITEGIAATLEKSAVVTKPTTEMIAETKLSDE 595

Human   168 --------------------PSAFP------------------QTPAAPP----------ATLGE 184
                                |.:.|                  .:|..||          ..|.|
  Fly   596 VVIEPPLKDESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPECCTLESVSGPVLLE 660

Human   185 GSADTEDRKLP-APGADVKVHRARKTMPKSVVGLHA--ASKDPR---EVREARDHKEPKEEINKN 243
            .|..||::... .....:|...|::..|.:.....|  :|::|.   |..|:...:..::|:.|.
  Fly   661 TSLSTEEKSNENVETTPLKTEAAKEDSPPAAPEEEASNSSEEPNFLLEDYESNQEQVAEDEMMKC 725

Human   244 ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTK 308
            .:..|::|  .|.|.:.:  |:..                :|..||:|:|....     |.:.:.
  Fly   726 NNQKGQKQ--TPLPEMKE--PEKP----------------VAETVSKKEKAMEN-----PARSSP 765

Human   309 VLKQRTVI--EMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAA 371
            .:..:.|.  ||.|.:..||.|:..||              :|||.:              ..||
  Fly   766 AIVDKKVRAGEMEKKVVKSTKGTVPEK--------------KMDSKK--------------SCAA 802

Human   372 AFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKT 436
            ..|.:               ||..|:|.:|.......|:|:...:.|.||.:::.|     |||.
  Fly   803 VTPAK---------------QKESGKSAKEAILKKETEKEKSSAKLDSSSPNTLDK-----KGKD 847

Human   437 DSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGD-----STGYMEVS----LDSLDL 492
            .:.|....:...:.|.|.|..:..|...|:   ::.|.||.:     ..|..:.|    |.:.:.
  Fly   848 TAQWSPQLQTLPKSSTKPPQESAPSVISKT---TSNQPAPKEEQHAAKKGLSDNSPPSVLKAKEK 909

Human   493 RVKGILSS----QAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTL--ANNQCMATESVDH 551
            .|.|.:..    :|..|||....|:....:::.....::|.|...|..|.  ...|   .:|:..
  Fly   910 AVSGFVECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVEAPPKVEPPTAVPVPGQ---KKSLSG 971

Human   552 ELGRCTNSVVKYE----LMRPSNKAPLLVLCEDHRGRM----VKHQCCPGCGYFCTAGNFMECQP 608
            :.....|:|  ||    |.|.|:.:..........|::    ||.:..|.....|.|...:....
  Fly   972 KTSLRRNTV--YEDSPNLERNSSPSSDSAQANTSAGKLKPSKVKKKINPRRSTICEAAKDLRSSS 1034

Human   609 ESSISHR---------FHKDCASRVNNASYCPHCGEESSK--AKEVTIAKADTTSTVTPVPGQEK 662
            .||...|         ...|.:|:.|.:.......:..||  .:..||.:.....|..|||
  Fly  1035 SSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRRYTICEDRQPETAIPVP---- 1095

Human   663 GSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQG--PGKETLES 725
               |..|..:....|:..|| .|..||                     |.|..:|  .|||:| |
  Fly  1096 ---LTKRRFSMHPKASANPL-HDTLLQ---------------------TAGKKRGRKEGKESL-S 1134

Human   726 ALIALDSEK------PKKLRFHPKQLYFSARQGELQKVLLMLVDGID---PNFKMEHQN-KRSP- 779
            ...:|||..      |||     |.|    :..|:....|:..:..:   ...||...: :.||
  Fly  1135 RQNSLDSSSSASQGAPKK-----KAL----KSAEILSAALLETESSESTSSGSKMSRWDVQTSPE 1190

Human   780 LHAAAEAGHVDICHMLVQAGANI---DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAE 841
            |.||...|  ||. ..::.|.|:   |...||||   .|..:....||           ||::.|
  Fly  1191 LEAANPFG--DIA-KFIEDGVNLLKRDKVDEDQR---KEGQDEVKREA-----------DPEEDE 1238

Human   842 GSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 906
                  .|.:..:.|......:......|.:|....|.::           |.|.:.|.
  Fly  1239 ------FAQRVANMETPATTPTPSPTQSNPEDSASTTTVL-----------KELETGGG------ 1280

Human   907 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLK 971
                                                      ..|.:|               :|
  Fly  1281 ------------------------------------------VRRSHR---------------IK 1288

Human   972 NK-EGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSE 1035
            .| :|....|...:.|...:.:.|.:.|.:.|.                         :.|::.:
  Fly  1289 QKPQGPRASQGRGVASVALAPISMDEQLAELAN-------------------------IEAINEQ 1328

Human  1036 PCPS----NYKYVSQNCVTSPMNIDRNITHLQYCVCI---DDCSSSNCMCGQLSMRCWYDKDGRL 1093
            ...|    .::.:.:|.......:.:....:| |.|.   |:.:..:..||.
  Fly  1329 FLRSEGLNTFQLLKENFYRCARQVSQENAEMQ-CDCFLTGDEEAQGHLSCGA------------- 1379

Human  1094 LPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEY 1158
                ......|:.||...||....|.|:..|.......:::||...|.|:.:...||||.|:.||
  Fly  1380 ----GCINRMLMIECGPLCSNGARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEY 1440

Human  1159 VGELISDSEADVREEDSYLFDLDNK--------DGEVYCIDARFYGNVSRFINHHCEPNLVPVRV 1215
            |||:|...|.:.|:   :|:..|..        .||. .|||...||:||:|||.|:|| ...:.
  Fly  1441 VGEVIDSEEFERRQ---HLYSKDRNRHYYFMALRGEA-VIDATSKGNISRYINHSCDPN-AETQK 1500

Human  1216 FMAHQDLRFPRIAFFSTRLIEAGEQLGFDY--------GERFWDIKGKLFSCRCGSPKCR----- 1267
            :..:.:|   ||.|||.:.|:.||::.|||        .:|          |.|.:..||
  Fly  1501 WTVNGEL---RIGFFSVKPIQPGEEITFDYQYLRYGRDAQR----------CYCEAANCRGWIGG 1552

Human  1268 -----------HSSAALAQRQASAAQEAQEDGLPDTSSAAAA 1298
                       ..|.:.|:......:...|:|.|..|:.|.|
  Fly  1553 EPDSDEGEQLDEESDSDAEMDEEELEAEPEEGQPRKSAKAKA 1594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHMT1	XP_011517323.1	EHMT_ZBD	517..647	CDD:411018	29/150 (19%)
		ANKYR	723..979	CDD:440430	48/270 (18%)
		ANK repeat	745..771	CDD:293786	3/28 (11%)
		ANK repeat	777..806	CDD:293786	11/32 (34%)
		ANK repeat	808..839	CDD:293786	8/30 (27%)
		ANK repeat	841..873	CDD:293786	4/31 (13%)
		ANK repeat	875..906	CDD:293786	4/30 (13%)
		ANK repeat	908..939	CDD:293786	0/30 (0%)
		ANK repeat	941..972	CDD:293786	2/30 (7%)
		SET_EHMT1	1039..1269	CDD:380933	67/268 (25%)
Set2	NP_572888.2	valS	<709..832	CDD:237855	36/190 (19%)
		AWS	1358..1410	CDD:197795	14/69 (20%)
		SET_SETD2	1410..1551	CDD:380949	51/158 (32%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404