Protein Alignment EHMT1 and G9a

DIOPT Version :10

• Sequence 1: XP_011517323.1
• Gene: EHMT1 / 79813
• HGNCID: 24650
• Length: 1301
• Species: Homo sapiens
• Sequence 2: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Alignment Length: 1588
• Identity: 417/1588 - (26%)
• Similarity: 652/1588 - (41%)
• Gaps: 418/1588 - (26%)

Human     4 KQETWYLAVPARGEPQQDCCVKTEL-LGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDAS 67
            |:|...||...:.|...:....|.: :...:|:.....|.:       :|||. ||    ...|:
  Fly   185 KEEEPILAATQKLEANAEPLTTTRIEVAVASPLVVSSASVK-------LAADA-TN----QMRAA 237

Human    68 SHANAAKHTQDSARVNPQDGT----------NTLTRIAENGVSERDSEAAKQNHVT-ADDFVQTS 121
            :.|.||.....:.:|:| .||          :|.|.:.:..|...:.:..|....| ....::..
  Fly   238 TSAGAATLADKNVQVSP-GGTRRSRRTPRPIDTPTSVTDEHVQVENKKFGKSEQYTDCSSHLERF 301

Human   122 VIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGR--TPSAFPQT-----PAAPP 179
            .:..|..|: :..|:::|.:.:.| |.|...::|.....|.|:.|  .|.|..:|     |...
  Fly   302 TLDDNTAIV-RLQLKSEPDKPSLT-ALSPEENSAPAPKRGRGRARKIRPDAEVETSEVILPCED- 363

Human   180 ATLGEGSADTEDRKLP------------------------APGADVKVHRARKTMPKSV-VG--L 217
             :|||.....: ||||                        ||..||      |.|.:|| :|  |
  Fly   364 -SLGEKKPGRK-RKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDV------KRMRRSVRLGNRL 420

Human   218 HAASKDPREVREARDHKEPKEEINKNISDFGR--QQLLPPFPSLHQSLPQNQCYMATT-----KS 275
            ||......||:....|.:|..|::     |..  .::||......::.|:.:...|.|     :|
  Fly   421 HADGSPWEEVKTEALHPQPSAELS-----FAEVTSEILPLAVLDEKTPPKKRGRKAKTPCVKLES 480

Human   276 QTAC-LPFVLAAAVSRKKKRRMGTYSL-VPKK---------------------KTKVLKQRTVIE 317
            :|:| |||    |...||....|...| :||:                     :||.:::.|..|
  Fly   481 ETSCGLPF----ANGNKKTNSSGGCELQLPKRSKRRIKPTPKILENDELRCEFETKHIERMTQWE 541

Human   318 MFKSITHS----TVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDS 378
            ...::...    |.|..|.          |..:....||:.|....|...||        |...|
  Fly   542 SAAAVDGDFETPTTGGNGS----------NSSTSRQKSDKSDGSNFEGGPGH--------PAGTS 588

Human   379 RTSKESMSEADR-----------------------------AQKMDGESEEEQESVDTGEEEEGG 414
            ...|...|::.|                             |.:::.....|:..::..::.:
  Fly   589 AIKKRLFSKSQRDIENYGAAMLAKSKLPPCPDVEQFLNDIKASRINANRSPEERKLNKKQQRK-- 651

Human   415 DESDLSSESSIKKKFLKRKG---------------KTDSPWI--------KPA---RKRRRRSRK 453
                |:.:   |:|.||..|               .||:.:.        ||:   |.|...:::
  Fly   652 ----LAKQ---KEKHLKHLGLQKNHRDEPSDNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKE 709

Human   454 KPSGALGSESYKSSAGSAEQT------APGDSTGYMEVS----------LDSLDLRVKGILSSQA 502
            .|:.|...........:|:.|      |.|:.|.....|          |.|||..::.
  Fly   710 LPTTATLKSRRNPVVQAAKLTRRIGARAAGEVTEAARASVPISTPDAEQLHSLDTSIQA------ 768

Human   503 EGLANGPDVLETDGLQEVP--------LCSCR-------METPKSREITTLANNQCMATESVDHE 552
                   ||.....|...|        :|.|:       ...|.|        :.|.|.:.:|.:
  Fly   769 -------DVTPIRDLDMRPSTSRVSKFICLCQKPSQYYARNAPDS--------SYCCAIDHIDDQ 818

Human   553 LGRCTNSVVK--YELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHR 615
            ...|.|.:..  :.|:|||.:...::||::|:.|:..|.||.|||.|||.|.|:.|:.:    |.
  Fly   819 KIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQ----HF 879

Human   616 FHKDCASR-VNNASY----------------------CPHCG-EESSKAKEVTI----------- 645
            ||.|||.| :.:.||                      ||||| :...:...||:
  Fly   880 FHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTPERTSTVTMKCQSLPVFLRT 944

Human   646 -------AKADTTSTVTP--------VPG---QEKGSALEGRADTTTGSAAGPPLSEDDKLQGAA 692
                   |:..|:|.:|.        .||   :.||    |.:...|.|||..|.|:.:
  Fly   945 QKYKIKPARLTTSSHLTQFGTVENANTPGATARNKG----GLSTAVTLSAASSPASKTN------ 999

Human   693 SHVPEGFDPTGPAGLGRPTPGLSQGPGKETLES---ALIALDSEKPKKLRFH------------- 741
                         |..|...|.|....:..|.|   |.:..:|.....||.|
  Fly  1000 -------------GAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFT 1051

Human   742 PKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN----I 802
            |:.:|::.:..:|::|..:|....:....:......:.||..|.:|.:.:.::|:..||:    :
  Fly  1052 PRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMAYLLLCKGASSPDFV 1116

Human   803 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 867
            :....:.||.||.|..|...:.:...::.||.|..|..:|.|.||:||:.|:.|..|.::.:.:.
  Fly  1117 NIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLGNLEATQLIVDSYRT 1181

Human   868 D---------VNCQDDGGWTPMIWATEYKHVDLVKL--------------------LLSKGSDIN 903
            .         ::.||:||||.|:||.|..|.|:|:|                    ||::.:|.|
  Fly  1182 SRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIFLFISFLLNQDADPN 1246

Human   904 IRDNEENICLHWAAF-SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSD 967
            |.||:.|..|||:.. :..:|...:||.:..|.:..|:.||:|||||.|.:.....:..::..:|
  Fly  1247 ICDNDNNTVLHWSTLHNDGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGAD 1311

Human   968 VTLKNKEGETPLQC-----ASLNSQVWSALQMSKALQDSAPDRPSPVER-IVSRDIARGYERIPI 1026
            :.:|||..:.|..|     :.....|...:||...       ||..:.. :|..|.:.|.|..||
  Fly  1312 LMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSF-------RPLGLRTFVVCADASNGREARPI 1369

Human  1027 PCV----------NAVDSEPCPSNYKYVSQNCV--TSPMNIDRNITHLQYCVCIDDCSSSNCMCG 1079
            ..|          :..||...| :::||:| |:  .:.:.|||.::.::.|.|:|.|||..|.|.
  Fly  1370 QVVRNELAMSENEDEADSLMWP-DFRYVTQ-CIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCN 1432

Human  1080 QLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWR-NCRNRVVQNGLRARLQLYRTRDM--GW 1141
            ..|.:.||..:.||..:||..:|.:|||||..|.|.: :|:|||||||.|..||:....|.  ||
  Fly  1433 GASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGW 1497

Human  1142 GVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHC 1206
            |||:|.::|.||||..|.||:::..|||.|.:|||.|||||.    :||||.:||||:||.||.|
  Fly  1498 GVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFDLDNG----HCIDANYYGNVTRFFNHSC 1558

Human  1207 EPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGK-LFSCRCGSPKCRH-- 1268
            |||::|||||..|||.|||:|||||.|.|:|||::.|||||:||.::.: ...|||.:..|::
  Fly  1559 EPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCKYAS 1623

Human  1269 --SSAALAQRQASAAQEAQEDGLPDTSS 1294
              ||...:...|:.|.|.:...|..|::
  Fly  1624 QSSSTNASPTNATTAPENETGTLSSTNT 1651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHMT1	XP_011517323.1	EHMT_ZBD	517..647	CDD:411018	47/188 (25%)
		ANKYR	723..979	CDD:440430	80/305 (26%)
		ANK repeat	745..771	CDD:293786	4/25 (16%)
		ANK repeat	777..806	CDD:293786	7/32 (22%)
		ANK repeat	808..839	CDD:293786	9/30 (30%)
		ANK repeat	841..873	CDD:293786	9/40 (23%)
		ANK repeat	875..906	CDD:293786	17/50 (34%)
		ANK repeat	908..939	CDD:293786	8/31 (26%)
		ANK repeat	941..972	CDD:293786	9/30 (30%)
		SET_EHMT1	1039..1269	CDD:380933	116/239 (49%)
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	1/2 (50%)
		EHMT_ZBD	786..933	CDD:411018	44/158 (28%)
		ANKYR	1063..1322	CDD:440430	71/258 (28%)
		ANK repeat	1088..1120	CDD:293786	7/31 (23%)
		ANK repeat	1124..1153	CDD:293786	9/28 (32%)
		ANK repeat	1155..1196	CDD:293786	9/40 (23%)
		ANK repeat	1199..1249	CDD:293786	16/49 (33%)
		ANK repeat	1251..1283	CDD:293786	8/31 (26%)
		ANK repeat	1285..1316	CDD:293786	9/30 (30%)
		SET_EHMT	1391..1622	CDD:380941	117/236 (50%)