Protein Alignment EHMT1 and set-11

DIOPT Version :10

• Sequence 1: XP_011517323.1
• Gene: EHMT1 / 79813
• HGNCID: 24650
• Length: 1301
• Species: Homo sapiens
• Sequence 2: NP_001364763.1
• Gene: set-11 / 185242
• WormBaseID: WBGene00018023
• Length: 278
• Species: Caenorhabditis elegans
• Alignment Length: 281
• Identity: 95/281 - (33%)
• Similarity: 137/281 - (48%)
• Gaps: 33/281 - (11%)

Human  1000 DSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEP-------CPSNYKYVSQNCVTSPMNIDR 1057
            |.|..:|    .::..||::|.||..:|    |.|.|       ...|:||.|:....:.....|
 Worm    11 DVAKQQP----MVLYEDISQGCERFVVP----VYSNPRFFMDSSLFENFKYTSRIIDVAGQLACR 67

Human  1058 NITHLQYCVCIDDCSSSNCMC--GQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRN 1120
            :.:....|.|...| |:||.|  |...       :|..:....:.....:.|||..|:|...|.|
 Worm    68 SASPTFMCQCAGQC-STNCECSSGVFG-------EGGTVENMELLMWDTVRECNEYCNCALWCGN 124

Human  1121 RVVQNGLRARLQLYRTRD--MGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNK 1183
            ||.|.|....:::: .||  .|||||:..||..|||:.||.||||.|.||..|.:.::||  :.|
 Worm   125 RVAQKGAMYPVEIF-ARDPWCGWGVRASVDIAFGTFIGEYAGELIDDEEAMDRHDSTFLF--ETK 186

Human  1184 DG-EVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGE 1247
            .| |...|||::.||.:|||||.|.||:....:...:..::...:.||:.:.|..||:|..||||
 Worm   187 VGSETLTIDAKYSGNYTRFINHSCAPNVKVANISWDYDKIQLIHMCFFTDKAIRKGEELTIDYGE 251

Human  1248 RFWDIKGKLFSCRCGSPKCRH 1268
            .:|  ..|.|.|.|.|.:||:
 Worm   252 AWW--ANKKFPCLCKSSECRY 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHMT1	XP_011517323.1	EHMT_ZBD	517..647	CDD:411018
		ANKYR	723..979	CDD:440430
		ANK repeat	745..771	CDD:293786
		ANK repeat	777..806	CDD:293786
		ANK repeat	808..839	CDD:293786
		ANK repeat	841..873	CDD:293786
		ANK repeat	875..906	CDD:293786
		ANK repeat	908..939	CDD:293786
		ANK repeat	941..972	CDD:293786
		SET_EHMT1	1039..1269	CDD:380933	83/235 (35%)
set-11	NP_001364763.1	PreSET	21..117	CDD:128744	26/107 (24%)
		SET	75..270	CDD:394802	77/207 (37%)