DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MYH14 and Mhc

DIOPT Version :9

Sequence 1:XP_011525622.1 Gene:MYH14 / 79784 HGNCID:23212 Length:2043 Species:Homo sapiens
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2018 Identity:754/2018 - (37%)
Similarity:1171/2018 - (58%) Gaps:106/2018 - (5%)


- Green bases have known domain annotations that are detailed below.


Human    57 PGPV----PEAAQPFLFTPRGPSAGGGPGSGTSPQVE----WTARRLVWVPSELHGFEAAALRDE 113
            |.||    .|...|:||.           |....:::    :.:::..|:|.|..|:....::..
  Fly     2 PKPVANQEDEDPTPYLFV-----------SLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKAT 55

Human   114 GEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYS 178
            ..:...|.| :.|....:..::::::|||||.|.||||::|.||...||||||:|||:.||||||
  Fly    56 KGDIVSVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYS 119

Human   179 GLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAG 243
            |||||.|||||:.|:||....:|||||:|:|||||::|:::|||..||.:..:||:|.|||||||
  Fly   120 GLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAG 184

Human   244 KTENTKKVIQYLAHVASSPKGRKEPGVPASVSTVSYGELERQLLQANPILEAFGNAKTVKNDNSS 308
            |||||||||.|.|.|.:|.|        ...:..|.|.||.|::|.||:||||||||||:|||||
  Fly   185 KTENTKKVIAYFATVGASKK--------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSS 241

Human   309 RFGKFIRINFDVAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLK-ADLLLEPC 372
            ||||||||:|...|.:.||:||||||||:|.|.|...|.|:|||||::.|:...:| ..||.:..
  Fly   242 RFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNI 306

Human   373 SHYRFLTNGPSSSPG-QERELFQETLESLRVLGFSHEEIISMLRMVSAVLQFGNIALKRERNTDQ 436
            ..|..::.|..:... .:.|.|..|.::..:|||:.:|...:.|:.:||:..|.:..|:....:|
  Fly   307 YDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQ 371

Human   437 ATMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFR 501
            |.........::.:|.|....:..:.||.||||||.::|.:.:..:|...::.||.|..::|||:
  Fly   372 AEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFK 436

Human   502 WLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEY 566
            |||.:.|..||...:: ..|:|:|||||||||:.|.|||||||:|||||||.|||.|||||||||
  Fly   437 WLVKKCNETLDTQQKR-QHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEY 500

Human   567 QREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQ-GGHPKF 630
            :||||.|.|:|||:||..||||||:|.   |:|::|:||..||||||::|.||:.... |....|
  Fly   501 KREGIDWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPF 562

Human   631 QRPRHLR---DQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVEGI 692
            |:|:..:   ..|.|::.||||.|.|....||.||.|||||.|.....:|.::|..||:.|..| 
  Fly   563 QKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAG- 626

Human   693 VGLEQVSSLGDGPPGGRPRR-GMFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLE 756
                 .|..|:...|||.:: |.|.||...|||.|:.||.||.:|.|.|||||:||..|:.|.::
  Fly   627 -----QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVD 686

Human   757 PRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDGKQACEKMIQALEL 821
            ..||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :|....|:|.|.:|:.::|
  Fly   687 AHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDL 750

Human   822 DPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQR 886
            ..:.||:|.:|:|||||||.|:||.||.::..|:...||.|||||:|:.|:|.|:|:.||:|:||
  Fly   751 PEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQR 815

Human   887 NCAAYLKLRHWQWWRLFTKVKPLLQVTR-QDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQ 949
            |...||:||.|.|::|:.||||||.|:| :||:  ||.:| .:|.:||.....:...||:...|:
  Fly   816 NLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEI--ARLEEKAKKAEELHAAEVKVRKELEALNAK 878

Human   950 LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQ 1014
            |..|:..|.:.|..|.....:.:|...:|.|:|.:||..:.:::.|:.:||:...|:..:||:..
  Fly   879 LLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKAD 943

Human  1015 QHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1079
            |.|..|:..:|..|...||.:.:|.|.:.:::...:::...::..:||:||:|:..:...:...:
  Fly   944 QEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEE 1008

Human  1080 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1144
            ....|:|:..|||::.|.|.|:.::||.|.:|:|.|.::||.||:::|:....||.:.:.::..:
  Fly  1009 LQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKK 1073

Human  1145 ELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL 1209
            ||...:.||::||.:..|:.|||.....:..:.::|.||.:.|.:|::|:||.||.||||||.||
  Fly  1074 ELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADL 1138

Human  1210 GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA 1274
            ..|||.|...||:...:|:||.||..|||.|:::|::.|||....||:.:..||::|..|:.|:|
  Fly  1139 ARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMA 1203

Human  1275 EQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERA 1339
            ||::|..:.|...||.:.....::::|||.:..:...:...|:..::|:..|.|||.:..:..|.
  Fly  1204 EQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRT 1268

Human  1340 RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVR 1404
            ..:.....::...|..::...|.||||:..:|||...|...||.|.:.|..||:|.:..|..:.|
  Fly  1269 LNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFR 1333

Human  1405 AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGA-LEAGEEARRRAAREAEA 1468
            .:|.:...||||:||||..:....|:|..|.|:...||.:.|.:..| .|..|||:|:       
  Fly  1334 NLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRK------- 1391

Human  1469 LTQRLAEKTETVDR-------LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1526
            |..||||..||::.       ||:.::||..|::|..:::::...:.:..||||:.||:::.|.|
  Fly  1392 LQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWK 1456

Human  1527 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKS 1591
            ..|.....|.:.::.|.|........|..|.||.||..|.:.|:|:.|..|::.||....:.|::
  Fly  1457 LKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRN 1521

Human  1592 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERR 1656
            :||:|:|.:..|...::|:|.:.|.|..|...|:..||.::.:..::.:.:|.:|.::|..|..|
  Fly  1522 IHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTR 1586

Human  1657 RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1721
            :...:.|...:...:.|.|.:..|:..:||||.::.||:..:..|.:...||.|.:::.|.|:|:
  Fly  1587 KNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKD 1651

Human  1722 LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ---DRDEMADEVA 1783
            :...:||.:.:|::...|...||:|...|:.|:...:..|..:||.||||:|   |..|..:||:
  Fly  1652 IQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVS 1716

Human  1784 NGNLSKAAILEEKRQLEGRLGQLEEELEE---EQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1845
            ..|   |:|...||:||..|..|..:|:|   |..|||   ::.:|.::....|..||.||:..:
  Fly  1717 AQN---ASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLADELRAEQDHA 1775

Human  1846 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1910
            ...|..|:.||:||:||:.||.|.:|.|....|..|..||.::.:.|.:|:.|.|....:.|.:|
  Fly  1776 QTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLR 1840

Human  1911 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1975
            ::|:|:||:..|.||:|:..::::|.::|...::|..|||:|||||.|:...|..|:.|:|||:.
  Fly  1841 KSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEA 1905

Human  1976 TESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSPPA 2040
            .|.|:...:.::..|.:.|.|.:                            |.|.||.|..: ..
  Fly  1906 EERADLAEQAISKFRAKGRAGSV----------------------------GRGASPAPRAT-SV 1941

Human  2041 HPQ 2043
            .||
  Fly  1942 RPQ 1944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH14XP_011525622.1 Myosin_head 148..836 CDD:278492 336/694 (48%)
MYSc_Myh14_mammals 159..836 CDD:276893 329/683 (48%)
Myosin_tail_1 913..1993 CDD:279860 344/1095 (31%)
GBP_C <1661..1761 CDD:303769 26/99 (26%)
coiled coil 1729..1746 CDD:293879 4/16 (25%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 7/37 (19%)
MYSc 81..777 CDD:214580 351/714 (49%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 329/683 (48%)
Myosin_tail_1 842..1897 CDD:279860 336/1069 (31%)
V_Alix_like 1557..1877 CDD:187408 100/325 (31%)
ATP-synt_B <1671..1771 CDD:304375 36/105 (34%)
TMPIT 1739..>1825 CDD:285135 30/88 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 86 1.000 Domainoid score I8070
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.820

Return to query results.
Submit another query.