DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pkp1b and p120ctn

DIOPT Version :9

Sequence 1:	XP_001338299.2	Gene:	pkp1b / 797838	ZFINID:	ZDB-GENE-030131-417	Length:	736	Species:	Danio rerio
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	790	Identity:	195/790 - (24%)
Similarity:	328/790 - (41%)	Gaps:	131/790 - (16%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MMPEPLKSALSLGNMEDTSLAVPSDIEHRSAQQRVLEQVHTIKKSKSKYRSKSK----SVSALAT 61
            |....||.:|...||..|.:.:...:.|..|..            :|::.|...    |.:..::
  Fly     1 MEARSLKHSLIGLNMNSTHINMDLSLTHEPANM------------QSQFGSFQNYDQFSAAGYSS 53

Zfish    62 SP---TSPEGDSVFYDFKFSPGTSLSGPSFNRGGNMTNGAMQRQNILRKSTNSRSSSGQQVNSN- 122
            :|   |.|.|....  .|.:|..|                   ||  :..|||..:|...:.::
  Fly    54 TPLYITKPTGVGAI--TKVAPHCS-------------------QN--KIETNSTDNSIPDIENHP 95

Zfish   123 ---------SGRF-DRSIYGFQG------SVSTQQKTSNQLYNKSTRSAPDLGFQPTTNGMSSTG 171
                     :|:: |.|.||..|      |..|.:......|   |..|...|.|.||:.:....
  Fly    96 LATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCY---TSDANYTGIQNTTSSIKPFS 157

Zfish   172 QRSQTSRQTFQRWEKGSQMPSSSYSNGTTLVRMSN----------------SNQVNAVSRRPSSL 220
            .|                 |.:...||...|..|.                .:.:|.|.:|.
  Fly   158 GR-----------------PFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRL--- 202

Zfish   221 QSNGESRMSMIRSGQAKDFSGMTLEKPVSDMTMRDAVDCLSSTDENVQLCGASYIQHSTFNDDKA 285
                |.:...|...:....|.|....|    .:.:.:..||:....::...|:|:||..:.||..
  Fly   203 ----EEKDDYIEGSENDICSTMRWRDP----NLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPN 259

Zfish   286 KQEVLTLKGLPLLVDLLGSSSPQVQETVAAALRNAIF--KNLPNKQEVQRSGGIKQAAQLL-GDA 347
            ||...:|.|:|.||.||...||::.:....||||..:  :|..||:.::.:|||.....|| ...
  Fly   260 KQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQ 324

Zfish   348 NTETQKHLTGLLWNLSSEDGLKPDLLRTALPALTEKVIEPFSANTVDNANTSLAPEVFCNATACL 412
            .||.::.:||:|||:||.:.||..::..||.|:...||:|.|.........:....||.||:..|
  Fly   325 ETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGETCFSTVFRNASGVL 389

Zfish   413 RNLSGSKLANRQSMRNCKGLIDSLMRYTENCITAGMPDNQSLENCVCILHNLTYQLETEMPTLFN 477
            ||:|.:....|..:|||:.|::.|:......|......|:::|||||||.||:|:.:......::
  Fly   390 RNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYD 454

Zfish   478 KINALASQSHNRSSSSDAGPIICFRLQSQKLKQRGFD----YPVMEDNNPEGVGW---------L 529
            | :...:......|||....:.||....:|.:....|    |.:..|.:...|.:         |
  Fly   455 K-HPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKLNKGYEQL 518

Zfish   530 FHSKALQFYLNLLSSSERDATLEACCGTLQNLTANEGIVSNFLSQTIVQKLNGMKFITPLLQSTN 594
            :..:.:|:||:||.|.....||||..|.:|||:|.....|..:..| |:|..|:..:..||:...
  Fly   519 WQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRAT-VRKEKGLPILVELLRMEV 582

Zfish   595 PALQNSAVALLGNLSKSSQTNKVMAPQSLPQLVGFLNSGLSKKESSPEYDSAMATALRSANTLIN 659
            ..:..:....|.||:...:..:::...::..||..|.||..:.:.:.. |..:...|.:.|.:|.
  Fly   583 DRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNTS-DDTITAVLATINEVIK 646

Zfish   660 ADPDTGKNLLNNSLINNLYNMSLNRDLQKSS--KASALLLHNLWSNKNIQSFLKKNGMKKKSFVN 722
            .:|:..::||::..|:.|.|::..::...|.  |.::.:|:.:|.:..::...||||.|::.||
  Fly   647 KNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFV- 710

Zfish   723 EVTSAAFKSH 732
               |..|.:|
  Fly   711 ---SKHFTAH 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pkp1b	XP_001338299.2	ARM	257..364	CDD:237987	38/109 (35%)
		armadillo repeat	286..322	CDD:293788	15/35 (43%)
		armadillo repeat	328..362	CDD:293788	12/34 (35%)
		armadillo repeat	370..415	CDD:293788	13/44 (30%)
		ARM	528..652	CDD:237987	32/132 (24%)
		armadillo repeat	535..561	CDD:293788	12/25 (48%)
		armadillo repeat	567..609	CDD:293788	9/41 (22%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	38/113 (34%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	15/35 (43%)
		armadillo repeat	304..339	CDD:293788	12/34 (35%)
		ARM	307..442	CDD:237987	47/134 (35%)
		armadillo repeat	347..392	CDD:293788	13/44 (30%)
		armadillo repeat	515..556	CDD:293788	16/40 (40%)
		ARM	516..643	CDD:237987	33/128 (26%)
		armadillo repeat	562..596	CDD:293788	7/34 (21%)
		armadillo repeat	601..641	CDD:293788	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.800