DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FZD3 and fz2

DIOPT Version :9

Sequence 1:NP_059108.1 Gene:FZD3 / 7976 HGNCID:4041 Length:666 Species:Homo sapiens
Sequence 2:NP_001262037.1 Gene:fz2 / 40090 FlyBaseID:FBgn0016797 Length:806 Species:Drosophila melanogaster


Alignment Length:746 Identity:234/746 - (31%)
Similarity:328/746 - (43%) Gaps:190/746 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    17 MGHIGGHSL------------------FSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAME 63
            || :|||.|                  ..||.||:.||:.:.||.|..||.:||..|..|.|.:.
  Fly    36 MG-MGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVH 99

Human    64 PFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLP-CRRLCQRAYSECSKLMEMFGVPWPEDMEC 127
            .|.|:|.:.||.|.:.|||::|.|||:|.....|| ||.:|:||.|.|:.:|:.:...|||.|.|
  Fly   100 QFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMAC 164

Human   128 SRFPDCDEP------YPRLVDL------------------------------------------- 143
            ...|...:|      .|...:.                                           
  Fly   165 EHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGSTST 229

Human   144 ------------NLAGEPTEGAPVAVQ-RDYGFWCPRELKIDPDLGYSFLH-------------- 181
                        |..||...|...:.. |....:..:|..:........:|              
  Fly   230 KPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRI 294

Human   182 --VRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVC 244
              |.:|..||...:|..:|..||..:|.|.|.:|..:||.|..||:||..||:||||||:|.:.|
  Fly   295 AGVPNCGIPCKGPFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSAC 359

Human   245 YMMVSLIFFI-GFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILT 308
            |.||::.:.. .||..:.:||:..:..:  :||   |.|  :||::|::.|||.||.|:|||||:
  Fly   360 YFMVAVGYLSRNFLQNEEIACDGLLLRE--SST---GPH--SCTLVFLLTYFFGMASSIWWVILS 417

Human   309 ITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRY 373
            .||||||..|||:|||.|.:..||.:||.||...::.:|.::.::||.|.|:|:||..:.|.|:.
  Fly   418 FTWFLAAGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKT 482

Human   374 FVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLE-----KENQDKLVKFMIRIGVFSILYLVPLL 433
            ||||||.:|:|:|.:.|:||.:||.|:|..|..:     ....|||.|.|||||:||:||.||..
  Fly   483 FVLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPAT 547

Human   434 VVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSVFWV 498
            :|||||.||.||...|        .:....||........:|...:.::||.|||.|||.|..|:
  Fly   548 IVIGCYLYEAAYFEDW--------IKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWI 604

Human   499 GSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFA---QSLLRD-PNTPIIRKSRGTSTQGTSTH 559
            .|.||...|..|:            |::|..||..   |:|::. |..|                
  Fly   605 WSGKTLESWRRFW------------RRLLGAPDRTGANQALIKQRPPIP---------------- 641

Human   560 ASSTQLAMVDDQRSKAGS-IHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRH 623
                        ...||| :...|.|..|||      ..||.:..|       |:....|.|  |
  Fly   642 ------------HPYAGSGMGMPVGSAAGSL------LATPYTQAG-------GASVASTSH--H 679

Human   624 SSSHRLNEQSRHSSIRDLSNNPMTHITHGTS 654
            ...|.:.:|...|           |: ||.|
  Fly   680 HLHHHVLKQPAAS-----------HVXHGES 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FZD3NP_059108.1 CRD_FZ3 24..150 CDD:143558 52/205 (25%)
7tmF_FZD3 192..512 CDD:320161 139/325 (43%)
TM helix 1 201..226 CDD:320161 11/24 (46%)
TM helix 2 235..256 CDD:320161 9/21 (43%)
TM helix 3 287..313 CDD:320161 15/25 (60%)
TM helix 4 330..352 CDD:320161 7/21 (33%)
TM helix 5 366..391 CDD:320161 11/24 (46%)
TM helix 6 419..444 CDD:320161 17/24 (71%)
TM helix 7 473..498 CDD:320161 10/24 (42%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 502..507 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..666 24/119 (20%)
fz2NP_001262037.1 CRD_FZ5_like 63..182 CDD:143565 47/118 (40%)
Frizzled 308..618 CDD:279827 139/336 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X126
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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