Protein Alignment ASB13 and lrk-1

DIOPT Version :10

• Sequence 1: NP_078977.2
• Gene: ASB13 / 79754
• HGNCID: 19765
• Length: 278
• Species: Homo sapiens
• Sequence 2: NP_492839.4
• Gene: lrk-1 / 172995
• WormBaseID: WBGene00003068
• Length: 2393
• Species: Caenorhabditis elegans
• Alignment Length: 213
• Identity: 55/213 - (25%)
• Similarity: 96/213 - (45%)
• Gaps: 22/213 - (10%)

Human    20 RTPVHEAAQRGESLQLQQ-LIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNI 83
            |||:..||..|:...|:. |:.|...:|.|.....|.||.|:..|:...|..|:..|:.....:.
 Worm    58 RTPLMLAAHNGKLDSLRTILMLSPNSLNLVNDRGKTALHMAAESGETSIVLELVELGSDPMKSDN 122

Human    84 DGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECV-------------R 134
            :|...|..|..:|..|....|:....|.:..|..| :.:..||:|||::.|             |
 Worm   123 EGHCALELAQMAGHNEVAAKLIDAIQKESEDLNEAHTMIISACISGSADVVYEISRRFMEKKQSR 187

Human   135 LLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKL-HETALHHAAKVKNVDLI 198
            .::..|.|.|..     |.|.:||...|::.|:.||....::..:.: .:|.:|.|...:||:::
 Worm   188 EILFNGRNEEDE-----TALLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVL 247

Human   199 EMLIE-FGGNIYARDNRG 215
            ::.:| |...:.:.:|.|
 Worm   248 QLCLEKFPQLVKSTNNEG 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASB13	NP_078977.2	ANK 1	18..47		9/27 (33%)
		ANKYR	20..221	CDD:440430	55/213 (26%)
		ANK repeat	20..49	CDD:293786	10/29 (34%)
		ANK repeat	51..82	CDD:293786	8/30 (27%)
		ANK 2	51..80		8/28 (29%)
		ANK 3	84..113		7/28 (25%)
		ANK repeat	84..112	CDD:293786	7/27 (26%)
		ANK 4	116..145		10/42 (24%)
		ANK repeat	119..147	CDD:293786	10/40 (25%)
		ANK repeat	149..179	CDD:293786	8/29 (28%)
		ANK 5	149..178		8/28 (29%)
		ANK repeat	181..212	CDD:293786	7/32 (22%)
		ANK 6	181..210		7/30 (23%)
		SOCS_ASB13	237..278	CDD:239699
lrk-1	NP_492839.4	ANKYR	13..337	CDD:440430	55/213 (26%)
		ANK repeat	56..88	CDD:293786	10/29 (34%)
		ANK repeat	90..121	CDD:293786	8/30 (27%)
		ANK repeat	197..228	CDD:293786	9/35 (26%)
		ANK repeat	230..262	CDD:293786	7/31 (23%)
		ANK repeat	361..390	CDD:293786
		Ank_2	366..472	CDD:463710
		ANK repeat	398..432	CDD:293786
		LRR	<529..>778	CDD:443914
		leucine-rich repeat	534..555	CDD:275380
		leucine-rich repeat	556..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..627	CDD:275380
		leucine-rich repeat	628..654	CDD:275380
		leucine-rich repeat	655..684	CDD:275380
		leucine-rich repeat	687..718	CDD:275380
		leucine-rich repeat	719..742	CDD:275380
		leucine-rich repeat	743..765	CDD:275380
		leucine-rich repeat	803..856	CDD:275380
		LRR	<857..>953	CDD:443914
		leucine-rich repeat	857..883	CDD:275380
		leucine-rich repeat	884..906	CDD:275380
		leucine-rich repeat	907..931	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	977..1160	CDD:476819
		COR	<1239..>1336	CDD:406489
		Protein Kinases, catalytic domain	1699..1990	CDD:473864