DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGB and sol

DIOPT Version :9

Sequence 1:	NP_078970.3	Gene:	ADGB / 79747	HGNCID:	21212	Length:	1667	Species:	Homo sapiens
Sequence 2:	NP_476738.3	Gene:	sol / 44014	FlyBaseID:	FBgn0003464	Length:	1594	Species:	Drosophila melanogaster

Alignment Length:	802	Identity:	162/802 - (20%)
Similarity:	258/802 - (32%)	Gaps:	273/802 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    54 ADINSEKWDAGKGAKEKDKTGKSPVFHFFEDPEGKIELPPSLKIYSWKRPQDILFSQTPVVVKNE 118
            |..:::||..  .|...|....|.|......|.|   |..::...:..| :.:..:.||..::.|
  Fly   924 ASTSTKKWQC--PACTYDNCAASVVCDICSSPRG---LASAVLGEALGR-KSVRVALTPADIRQE 982

Human   119 --ITFDLFSANEHLLCSELMRW--II------SEIYAVWKIFNGGILSNYFKGTSGE---PPLLP 170
              :..:|....|   ...|.:|  ||      ||:: |...|.....|.|:...||.   .|::.
  Fly   983 SKLMENLRQLEE---TEALTKWQNIIQYCRDNSELF-VDDSFPPAPKSLYYNPASGAGEGNPVVQ 1043

Human   171 WK-------------PWEHIYS-----LCKAVKGHMPLFNS----------------------YG 195
            |:             ||....:     :|:.|.|:..|.::                      .|
  Fly  1044 WRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQG 1108

Human   196 KYVVKLYWMGCWRKITIDDFLPFDEDNNLLLPATTYEFELWPMLLSKAIIKLANIDIH------V 254
            .|.|:|...|.|..:.:||.||.|:..:|:......: :||..|:.||:.|     ||      |
  Fly  1109 AYQVRLCKDGKWTTVLVDDLLPCDKRGHLVYSQAKRK-QLWVPLIEKAVAK-----IHGCYEALV 1167

Human   255 ADRRELGEFTVIHALTGWLPEVISLHPGYM----------DKVW-ELLKEILPEFKLSDEASSES 308
            :.|...|    :..|||...|.|.|....:          |.:| :||......| |...:....
  Fly  1168 SGRAIEG----LATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRF-LMGASCGGG 1227

Human   309 KIAVLDSKLKEPGKEGKEGKEIKDGKEVKDVK------------------EFKPESSLTTLKAPE 355
            .:.|.:.:.::.|...:....:.|   |||::                  ::..:|||.|   .:
  Fly  1228 NMKVDEEEYQQKGLRPRHAYSVLD---VKDIQGHRLLKLRNPWGHYSWRGDWSDDSSLWT---DD 1286

Human   356 KSDKVPKEKA----------------DARDIGKKRSKDGEKEKFKFSLHGSRPSSEVQYSVQSLS 404
            ..|.:....|                |..||.|.||...|              ..:|.::|.|.
  Fly  1287 LRDALMPHGASEGVFWISFEDVLNYFDCIDICKVRSGWNE--------------VRLQGTLQPLC 1337

Human   405 DCSSAIQTSHMVVYATFTPLYLFENKIFSLEKMADSAEKLREYGLSHICSHPVLVTRSRSCPLVA 469
            ..|..:.|......|.||   ||:....:.||...|...|        |   |::.|:||
  Fly  1338 SISCVLLTVLEPTEAEFT---LFQEGQRNSEKSQRSQLDL--------C---VVIFRTRS----- 1383

Human   470 PPKPPPLPPWKLIRQKKETVITDEAQELIVKKPERFLEISSPFLNYRMTPFTIPTE-------MH 527
             |..|.:  .:|:...|..|........:::: :.:|.:...| |:..|....|.:       :|
  Fly  1384 -PAAPEI--GRLVEHSKRQVRGFVGCHKMLER-DIYLLVCLAF-NHWHTGIEDPHQYPQCILAIH 1443

Human   528 FVRSLIKKGIPPGSDLPSVSETDETATHSQTDLSQITKATSQGNTASQVILGKGTDEQTDFGLGD 592
            ..:.|:.:.|.|...|.:.:....|.|..|....:      :|.||..:..|..
  Fly  1444 SSKRLLVEQISPSPHLLADAIISLTLTKGQRHEGR------EGMTAYYLTKGWA----------- 1491

Human   593 AHQSDGLNLEREIVSQTTATQEKSQEELPTTNNSVSKEIWLDFEDFCVCFQNIYIFHKPSSYCLN 657
                 ||.:..|                   |...:|  |:..:  |.|         ..||.:.
  Fly  1492 -----GLVVMVE-------------------NRHENK--WIHVK--CDC---------QESYNVV 1519

Human   658 FQKSEFKFSEERVSYYLFVDSLKPIELLVC-----------FSALVR-------------WGEYG 698
            ..:.|.|          .|||:.|::..|.           ||...|             ||..|
  Fly  1520 STRGELK----------TVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRGLHDWGPPG 1574

Human   699 ALTKDSPPIE-------PGLLT 713
            |  ...||||       |.|:|
  Fly  1575 A--THCPPIENVHGLHAPRLIT 1594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGB	NP_078970.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		CysPc	<192..>299	CDD:294044	33/145 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..387		12/55 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..566		4/25 (16%)
		Mb_like	<780..853	CDD:271266
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1297..1355
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1522
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1646..1667
sol	NP_476738.3	zf-RanBP	6..34	CDD:279035
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:279035
		zf-RanBP	643..672	CDD:279035
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:279035
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:279035
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:279035	6/28 (21%)
		RanBP2-type Zn finger	931..950	CDD:275376	5/20 (25%)
		CysPc	1001..1328	CDD:128526	73/358 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900