DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGB and clp-2

DIOPT Version :9

Sequence 1:	NP_078970.3	Gene:	ADGB / 79747	HGNCID:	21212	Length:	1667	Species:	Homo sapiens
Sequence 2:	NP_497964.1	Gene:	clp-2 / 175618	WormBaseID:	WBGene00000543	Length:	805	Species:	Caenorhabditis elegans

Alignment Length:	626	Identity:	130/626 - (20%)
Similarity:	230/626 - (36%)	Gaps:	195/626 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    23 SKDFYPFGSNVQSGSTEQKKGKFPLWPEWSEADINSEKW----DAGKGAKEKDKTGKSPVFHFFE 83
            :::|.|..||.|..:.|:....|      :.::||::.:    :..|..:.|.:.||      |.
Worm   195 TRNFPPSPSNSQKFTKEELAVLF------TTSNINNKLYVPFHNYDKVNEFKGQQGK------FT 247

Human    84 DPEGKIELPPS--LKIYSWKRPQDILFSQTPVVVKNEITFDLFSANEHLLCSELMRWIISEIYAV 146
            ||||||.|...  :|:..|||..::.  :.|.::        ||.:    |..:.:.:||:...:
Worm   248 DPEGKISLTQKQRMKLKCWKRVSELF--ENPTII--------FSID----CHTIKQTVISDCSFI 298

Human   147 WKIFNGGILSNYFKGTSGEPPLLPWKPWEHIYSLCKAVKGHMPLFNSYGKYVVKLYWMGCWRKIT 211
            ..:....:....||.......:.|           :...| .|::|..|||:.|.:..|.|||:.
Worm   299 SSLSIAALYEKRFKKQLVTSIIFP-----------QDANG-KPIYNPAGKYMFKFHLNGAWRKVL 351

Human   212 IDDFLPFDEDNNLLLPATTYEFELWPMLLSKAIIKL----------ANIDIHVADRRELGEFTVI 266
            |||:.|.||:|.::...|..:.|||..||.||.:|:          :|||              :
Worm   352 IDDYFPVDENNRMMCSQTENKGELWVSLLEKAYMKVMGGYDFPGSNSNID--------------L 402

Human   267 HALTGWLPEVISLHPGYMDKVWELLKEILPEF------------KLSDEASSESKI------AVL 313
            :|||||:||.|.|.........|:.:::...|            |::::....|.:      ||:
Worm   403 NALTGWIPERIELSDTSKADPDEVFRKLFDRFHRGDCLITLATGKMTEDMQKRSGLVETHAYAVI 467

Human   314 D---------SKLKEPGKEGKEGKEIKDGKEV------KDVKEFKPESSLTTLKAPEKSDKV--- 360
            |         .|:|.|....:......|..:|      |:...|.||      .|.||.|.:
Worm   468 DIRCVETKRLLKVKNPWTHSRWKGNFSDKDKVNWTAKMKNALAFDPE------VAAEKDDGIFWI 526

Human   361 -------------PKEKAD------------ARDIGKKRS--KDGEKEKFKFSLHGSRPSSEV-- 396
                         ....||            .:|.|..|.  ..||..::..:::.::.::.|
Worm   527 DYESVRHFFDVIYVNWNADLFPFKSVYHATWTQDTGPIRDVYTVGENPQYTLTVNLNQKAAAVWI 591

Human   397 --QYSVQSLSDCSSAIQTSHMVVYATFTPLYLFENKIFSLEKMADSAEKLREYGLSHICSHPVLV 459
              ...:.::.|.:...:...::||.|...:|:..|.    :.::|...          .:.|:.:
Worm   592 LLTRHITAIDDFAVNKEFITLIVYETGQKIYIPSNP----QPISDGVR----------INSPLYL 642

Human   460 TRSRSCPLVAPPKPPPLPPWKLIRQKKETVITDEAQELIVKKPERFLEISSPFLNYRMTPFTI-- 522
                 |.|  ..|.|.:..:.|:..:.|...|                     :||.:..|:.
Worm   643 -----CQL--SNKKPGITKYTLVVAQYEKTNT---------------------INYSLRVFSTTD 679

Human   523 ----PTEMHFVRSLIKKGIPPGSD------LPSVSETDETA 553
                |.::.:..|...:|...|||      |...|::||.|
Worm   680 VKLEPVQLPYSISKTTRGNWDGSDKYPIMKLTLHSKSDEIA 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGB	NP_078970.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		6/21 (29%)
		CysPc	<192..>299	CDD:294044	39/128 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..387		11/69 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..566		8/20 (40%)
		Mb_like	<780..853	CDD:271266
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1297..1355
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1522
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1646..1667
clp-2	NP_497964.1	MIT	4..75	CDD:239121
		CysPc	227..551	CDD:128526	86/375 (23%)
		Calpain_III	<722..801	CDD:381833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D343870at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820