Protein Alignment NARS2 and AspRS

DIOPT Version :10

• Sequence 1: NP_001412228.1
• Gene: NARS2 / 79731
• HGNCID: 26274
• Length: 518
• Species: Homo sapiens
• Sequence 2: NP_476609.1
• Gene: AspRS / 36420
• FlyBaseID: FBgn0002069
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 131/537 - (24%)
• Similarity: 224/537 - (41%)
• Gaps: 128/537 - (23%)

Human    27 KLSVRDALGAQNASGE----RIKIQGWIRSVRSQKEVLFLHVNDGSS----------LESLQVVA 77
            |.|.|:.:.....||:    .:.::|.:.:.|::.:..||.:...||          :.|.|:|.
  Fly    68 KRSERNFVPVSELSGQVGKGLVWVRGRVHTSRAKGKQCFLILRQQSSTVQCILAVGDVISKQMVK 132

Human    78 DSGLDSRELNFGSSVEVQGQLIKSPSK-----RQNVELKAEKIKVIGNCDAKDFPIKYKERHPLE 137
            .:|...:|    |.:::|.:.:...||     .|::||..|:|.||....|: .|::.::....|
  Fly   133 FAGNIPKE----SIIDIQAKPVAVSSKIESCTEQSLELSVEQIFVISQAKAQ-LPLQIEDASRPE 192

Human   138 YLRQYPHFRCRTN----VLGSILRIRSEATAAIH-------SFFKD----SGFVHIHTPIITSND 187
            ..........|.|    :...:|.:|:.|..||.       ..|:|    .||..||||.|.|..
  Fly   193 NADDAEGLNIRVNQDTRLDNRVLDLRTPANQAIFRLEAGVCRLFRDILTEQGFTEIHTPKIISAA 257

Human   188 SEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEVMSGA-FTQVFTFGPTFRAENSQSRR 251
            |||...:|.:           ::|...|:|..|.||:.::...| |.:|:|.|..||||:|.:.|
  Fly   258 SEGGANVFTV-----------SYFKDSAYLAQSPQLYKQMAIAADFDKVYTVGAVFRAEDSNTHR 311

Human   252 HLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVEL--------CHKFIAPGQKD 308
            ||.||..::.|::|.....:::..|...|.:....:..|..:::|.        ..||:.|.
  Fly   312 HLTEFVGLDLEMAFKYHYHEVLHTIGNTFTSIFKGLRDKYAKEIESVGQQYKVDAFKFLEPP--- 373

Human   309 RLEHMLKNNFLIISYTEAVEILKQASQNFTFTPETRSLCVAEAGVQWCKHGSLQIPPPRLSSFLP 373
                      ||:.:.:.|.:|::|
  Fly   374 ----------LILQFADGVAMLREA---------------------------------------- 388

Human   374 TQSPNYLGLQWG--ADLRTEHEKY---LVKHCGNIPVFVIN-YPLTLKPFYMRDNEDGPQHTVAA 432
                   |::.|  .||.|.:||.   |||...:...:::: :||.::|||...:.:.|.:: .:
  Fly   389 -------GVETGDEEDLSTPNEKLLGRLVKAKYDTDFYILDKFPLAIRPFYTMPDPNNPVYS-NS 445

Human   433 VDLLVPGVGELFGGGLREERYHFLEERLARSGL-TEVYQWYLDLRRFGSVPHGGFGMGFERYLQC 496
            .|:.:.| .|:..|..|.....:|.||....|: |.....|::..|:|..||.|.|:|.||.:..
  Fly   446 YDMFMRG-EEILSGAQRIHDPEYLIERAKHHGIDTSKIAAYIESFRYGCPPHAGGGIGMERVVML 509

Human   497 ILGVDNIKDVIPFPRFP 513
            .||:|||:....|||.|
  Fly   510 YLGLDNIRKTSMFPRDP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NARS2	NP_001412228.1	asnC	27..515	CDD:235176	131/537 (24%)
AspRS	NP_476609.1	PLN02850	49..531	CDD:215456	131/537 (24%)