Protein Alignment SUV39H2 and Su(var)3-9

DIOPT Version :10

• Sequence 1: NP_001180353.1
• Gene: SUV39H2 / 79723
• HGNCID: 17287
• Length: 410
• Species: Homo sapiens
• Sequence 2: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 170/487 - (34%)
• Similarity: 245/487 - (50%)
• Gaps: 101/487 - (20%)

Human     5 GAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGI----TKRNLNNYEV--------EYLCDYKV 57
            |.|......:|   ||:...:| ::.:.:|  :|.    :||:.||..|        ||:.:...
  Fly   167 GCEEHDVDKIP---SLNGFAKL-KRRRSSC--VGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIE 225

Human    58 VKDMEYY----LVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKT 118
            ..:|:.|    .|||.|:.||.||||.|.|:.....:::|. ::|..|.::...|..|..:....
  Fly   226 CVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFV-ERHQQLYEIYIAKITTELEKQLE 289

Human   119 LKP-----AIAEY-----------IVKKAKQRIALQRWQDE------------------------ 143
            ..|     .:||.           ::..|:.|.|..|.|.|
  Fly   290 ALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQ 354

Human   144 ------LNRRKNH----KGMIFVENTVDLEGPPSDFYYINEY-------KPAPGISLVNEATFGC 191
                  ..:|.||    ...|.|||.:||:...|:|.||::.       ||..||       .||
  Fly   355 LADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGI-------VGC 412

Human   192 SCT----DCFFQ-KCCPAEAGVLLAYNKN-QQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQY 250
            .||    :|... |||...||.|.||.:: :::::.||:.||||||||.|...|.||:||.|.|.
  Fly   413 KCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQV 477

Human   251 SLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDY---ES 312
            .|.:|:|:||.||||:....:::..||.||:||:|||:||..||:.||:.|.||||||||   :.
  Fly   478 PLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQD 542

Human   313 DEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGS 377
            .|:|:|||.|||:|||:||||||||.||..:|::|:..||.:..|:.|.|.|||||:|||....:
  Fly   543 SEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADN 607

Human   378 GDISSDSIDHSPAKKRVRTVCKCGAVTCRGYL 409
            .|:..:::..:     ||..|:|||..||..|
  Fly   608 EDVPYENLSTA-----VRVECRCGADNCRKVL 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SUV39H2	NP_001180353.1	CD_SUV39H1_like	47..95	CDD:349289	18/59 (31%)
		SET_SUV39H2	167..409	CDD:380930	117/257 (46%)
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362
		Chromo	219..268	CDD:459793	16/49 (33%)
		SET_SUV39H	388..634	CDD:380940	117/257 (46%)