DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nim1kb and par-1

DIOPT Version :9

Sequence 1:	XP_001337548.3	Gene:	nim1kb / 797096	ZFINID:	ZDB-GENE-091204-283	Length:	433	Species:	Danio rerio
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	149/384 - (38%)
Similarity:	228/384 - (59%)	Gaps:	28/384 - (7%)

- Green bases have known domain annotations that are detailed below.

Zfish    64 KRVGFYKVRGQIGCGNFSKVKLATHALTKDKVAVKIMDKMRLDVQTQRMLTREISNMESLYHPNL 128
            :.:|.||:...||.|||:|||||.|..|..:||:||:||.:|:..:.:.|.||:..|:.|.|||:
  Fly   248 EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 312

Zfish   129 LQLFEVLETPSRLYLILEFAGGGDLHTRISSGGKLTDLESKIVFAQILSAVKYMHENNIIHRDLK 193
            ::||:|:||...||||:|:|.||::...:...|::.:.|:::.|.||:|||:|.|:..|||||||
  Fly   313 VKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 377

Zfish   194 AENVLYTTNGCIKVADFGFSTKVNNRNQALDTFCGSPPYAAPELFKDDSYIGPPVDVWAMGVLLF 258
            |||:|..:...||:||||||.:....:: ||||||||||||||||:...|.||.||||::||:|:
  Fly   378 AENLLLDSELNIKIADFGFSNEFTPGSK-LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY 441

Zfish   259 FMVTGSLPFRADTVPKLRQSVLEGAYVLPIWVSAPCQRLIRGILKPEPSERCALDQMLGCEWL-- 321
            .:|:|||||...|:.:||:.||.|.|.:|.::|..|:.|:|..|...|::|.:|:.::|.:|:
  Fly   442 TLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNM 506

Zfish   322 -LPVELFRP-IPPLYQLNPIHLLEA------GPGELDRDQEEVKG--------ILEKLGVTPEHI 370
             ...:..:| |.|...|.....:||      ...|::....:|:.        :|.:....||
  Fly   507 GFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPE-- 569

Zfish   371 LNNQGKRIRSPINGVYRILLHRVKRNRGAESV--PSISGVVKDPKRDSLRAYRNLRHSS 427
              :.|.|..|.:: :..|..:....|.|:.||  |:..||.:.....|.:..|  |.||
  Fly   570 --SDGSRSGSSLS-LRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSR--RASS 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nim1kb	XP_001337548.3	STKc_NIM1	66..321	CDD:270977	121/254 (48%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	120/252 (48%)
		S_TKc	253..504	CDD:214567	120/251 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	5/37 (14%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910