DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRRK1 and Lrrk

DIOPT Version :10

Sequence 1:NP_078928.3 Gene:LRRK1 / 79705 HGNCID:18608 Length:2015 Species:Homo sapiens
Sequence 2:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster


Alignment Length:2345 Identity:543/2345 - (23%)
Similarity:894/2345 - (38%) Gaps:673/2345 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    35 GDTGGKPSTRGGDP--AARSRRTEGIRAAYRR----GDRGGARDLLEE---ACDQ--------CA 82
            ||:....||    |  ..|.|.:.||:|...:    |:..|..||..:   .|.:        |.
  Fly   297 GDSASSVST----PITPTRKRISFGIQAIMSKLHISGESEGPDDLASQESTECQRCPINVNLLCG 357

Human    83 SQLEKGQLLSIPAAYGDLEMVRYLL----SKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESL 143
            :..|...|.::..  |.|::|:.||    :..:|..|.|..:| |......:|        |.::
  Fly   358 AARETALLAAVRG--GHLDVVQSLLQHGANPNIVAKPVEDHND-PKCCEEIYG--------LSNV 411

Human   144 PGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGA-DPESYAVRKNEFPVIVRLPLYAAIKSGNE 207
            |            :|.||::..|.::.|| |.||| |....|:.             .||..|:|
  Fly   412 P------------IAEACKQRSLAMLDLL-LKHGARDDNGTAIG-------------MAITCGDE 450

Human   208 DIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF---IEASP-LPSS--------YPGKTALRVKW 260
            .|...||....:         ||....:.:|..   :|.:. |||:        :|....: :.|
  Fly   451 AILSRLLARRVH---------PDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTI-IDW 505

Human   261 ---------SHLRLPW-VDLDWLIDISCQ------------ITELDLSANCLATLPSVIPWGLIN 303
                     |.:|:|| |....|::...|            ||.:|.|.|.|.::|..: :.|::
  Fly   506 HSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQEL-FHLVS 569

Human   304 LRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKL- 367
            ||.||::.|.:.:|| ........|..|.|:.:..|:|:.||....||..|..|..|.|.|::| 
  Fly   570 LRYLNVAQNKITDLP-APIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLP 633

Human   368 FEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDP---------- 422
            |:...|.      ||:||:::.|.|.:||...:.:..||  |::.:.||:.|.:|          
  Fly   634 FDLWRAP------KLRELNVAFNLLRDLPVPPMQTSSSL--LSLDKLNLQSFEEPPSNKPRNVTQ 690

Human   423 --------WACPLKCCKAS---RNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDA-L 475
                    |:..|......   ::..:....|.|....:.|..::.:.|....:|..|..|.. |
  Fly   691 QRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNL 755

Human   476 MFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQL--------------------------GKNED 514
            ..|.:..|.|.::.....:.. .||.||||.|::                          |:::|
  Fly   756 TRLNMSYNSLRSMGHVTSYPA-TLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDD 819

Human   515 GLKTKRIAFFTTRGRQRSGTE-AASVLE------------------------------------- 541
             .||.     :::|...|.|. .||||:                                     
  Fly   820 -YKTA-----SSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTL 878

Human   542 --------------------FPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRE 586
                                ||     :|.:|.:.:|.|..:|.|:..|.|||.|.:..|..:.|
  Fly   879 FNESEDADWSVVGVNRSKVIFP-----NLSMLDMTNNCLKEIPASLHELSSLSVLNISGNVNITE 938

Human   587 LPPELGQLGNLWQLDTEDLTISN-VPAEIQKEGPKAM--LSYLRAQLRKAEKCKLMKMIIVGPPR 648
            |||.||.|..||.|:|....:.. :.:.|:.:..|.|  :.||::....|:....||:::||...
  Fly   939 LPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVVGVAG 1003

Human   649 QGKSTLLEILQTGR------------------APQVVHGEATIRTTK------------------ 677
            .||||||::|:.|.                  |.::.|..:|.|:.:                  
  Fly  1004 IGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGT 1068

Human   678 W---ELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFW 739
            |   :.:|..||..   .|.|..||.||.......:|.|.:.::||:|:|.::.|.:.:|.|..|
  Fly  1069 WICEKRKRAPGSHG---PVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQW 1130

Human   740 LLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEI 804
            |.||:|:|||:.|::||||.|.:......::...|:..:.....:...:...|.|.:.  ...||
  Fly  1131 LGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVI--DSIEI 1193

Human   805 SCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEA--VLAEQQRRSRDDDV 867
            ||::|.....|..:|:.....::..||.   :.:..:.||.||::|::.  |:|...|.:..|.|
  Fly  1194 SCRTLHNIHLLANIIYDTAMQLRSPGSK---EPMLLQKIPASYIALEDIVNVIACNLRAAGRDPV 1255

Human   868 QYLTDRQLEQLV-EQTPDNDIKDYED---LQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLS 928
              |...|.::|| ||...::.|.:.|   ||.|.::..|.|.|||:.|.:  ||:.|||||.||.
  Fly  1256 --LDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDAT--LRDYYFLDPQWLC 1316

Human   929 ECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYF-QFLAKFEIALPVANDSYLLP 992
            :.|..:..::.....|..||::.:||:||.............|. ..|.|||:||...:.:.|:|
  Fly  1317 DMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIP 1381

Human   993 HLLPSKPGLDTHG--------------------------------MRHPTANT--------IQRV 1017
            .||||:.....:.                                ...|::::        ::|:
  Fly  1382 SLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRI 1446

Human  1018 FKMSFVPVGFWQRFIARML-----------ISLAEMDLQLFENKKNTKSRNR------------- 1058
            ..|::.|.|||.|.|.|:|           :.:|..|...|:.:.:.:...:             
  Fly  1447 LLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYG 1511

Human  1059 -----KVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKI 1118
                 |:....|...:|.:  .||...|:....|:|:.            ||||  ...|..:::
  Fly  1512 PILIFKIWEVPFQKTERTQ--PFRTDGNRFKLKQDGIW------------SDVN--LSSSSILEV 1560

Human  1119 --------VCQ----------SEVRDFSA-----MAFITDHVNSLIDQWFPALTAT---ESDGTP 1157
                    :.|          :|:|...:     :|...||::.|::.|:|:|...   .|:|..
  Fly  1561 YFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRF 1625

Human  1158 LMEQYVPCPVCETAW----AQHTDPSE-------------------------------------- 1180
            |:.:.|.||.|  .|    .|:.:||:                                      
  Fly  1626 LITRLVLCPRC--LWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNV 1688

Human  1181 -------------KSED--------------------------------------VQY-FDMEDC 1193
                         :|||                                      |.| :.:|:|
  Fly  1689 FSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEEC 1753

Human  1194 VLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVI- 1257
            :|:...:..||||.|  |...:.:|.|::...|.|.:..:.:..:    .:||:||:|..|.|. 
  Fly  1754 ILSVYNQSKISCPVH--LEQSMAQLAPDVIFADIPDKHTIPSECI----IKGSLLGRGAFGFVFK 1812

Human  1258 ----YRARYQGQPVAVKRFH------------IKKFKNFANVPADTMLRHLRATDAMKNFSEFRQ 1306
                .|.....:|||:|...            :..||..........|:|     :.|.:...||
  Fly  1813 ANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQH-----SCKAYCTARQ 1872

Human  1307 EASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIA 1371
            |.::|..|:||.||.|:||.|.||...||||||..|:.:|....|..:.  :|....|.:..|.|
  Fly  1873 ELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAH--MGPHTFQTLVLQAA 1935

Human  1372 SGLAYLHKKNIIFCDLKSDNILVWSL-------DVKEHINIKLSDYGISRQSFHEGALGVEGTPG 1429
            ..:.|||::.||:.||||:|:|||.|       ..:..::||::|||||||:...||.|..||.|
  Fly  1936 RAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEG 2000

Human  1430 YQAPEI---RPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQ 1491
            :.||||   .....|.||||.||:||.:||.:|.::|..||.  .|.:.:.:|.||.|.| .|.|
  Fly  2001 FMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHE--SIKECILEGSRPALTQ-RETQ 2062

Human  1492 FRR-LQALMMECWDTKPEKRPLALSVVSQMKDPTFATFM--------YELCCGK-QTAFFSSQGQ 1546
            |.. ...||:.||..:|.:||.|..:||.:..|.....:        .::.||. |:.......:
  Fly  2063 FPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDE 2127

Human  1547 EYTVVFWDGKEESRNYTVVNTEKG-LMEVQRMCC--------------------------PGMKV 1584
            ...:..|.....||...:..:..| |::...:.|                          |.|.:
  Fly  2128 RCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNM 2192

Human  1585 SCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLAD 1649
            .|...|..::|.......::.|:......|.:  ..|| |.:.:..:::..::|.: .|..|..:
  Fly  2193 LCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFS--YMLD-PNIKSAVISLVYMEKIA-RVAVGTHN 2253

Human  1650 GLVAVFPVVRGTPKDSCSY---------LCSHTANRSKFSIADED----------ARQNPYP--- 1692
            |  .||.|.......:|::         :||.....:..|:..:.          .:.|.:|   
  Fly  2254 G--RVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKINVFPLNE 2316

Human  1693 --------------------VKAMEVVNSGSEVWYSNGPGLLV-------------IDCASLEIC 1724
                                ||...:.::.|.|:....||.:|             :||:.|..|
  Fly  2317 NGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPC 2381

Human  1725 -RRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFP 1788
             ..|:.......|..:.|               :.::|..::|..| :...:.|.:.:.|..:.|
  Fly  2382 SESLQSIAIDEHVNLIKC---------------QISALAAHNSELY-IGTTWGCLIVAELHTLRP 2430

Human  1789 V---RPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPR 1850
            :   ||.:.|..:....:...||   .||.:...| ..|.::.:...||.|    .||..|:|..
  Fly  2431 ISVFRPYENEIKSIITLSKDNVP---LIATIGRRY-RSLISRYVDSAESST----KSSAVSTPTH 2487

Human  1851 QAARS 1855
            .||:|
  Fly  2488 GAAKS 2492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK1NP_078928.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..56 7/22 (32%)
ANK 1. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 51..81 10/44 (23%)
ANKYR 58..>218 CDD:440430 42/179 (23%)
ANK 2. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 86..116 8/33 (24%)
ANK 3. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 119..148 5/28 (18%)
ANK 4. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 152..182 11/30 (37%)
ANK repeat 156..186 CDD:293786 12/30 (40%)
ANK repeat 188..218 CDD:293786 7/29 (24%)
ANK 5. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 193..222 7/28 (25%)
LRR <279..>517 CDD:443914 70/298 (23%)
LRR 1. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 279..300 8/32 (25%)
leucine-rich repeat 281..303 CDD:275380 7/21 (33%)
LRR 2. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 303..324 7/20 (35%)
leucine-rich repeat 304..330 CDD:275380 8/25 (32%)
LRR 3. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 330..351 6/20 (30%)
leucine-rich repeat 331..353 CDD:275380 8/21 (38%)
LRR 4. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 353..374 7/21 (33%)
leucine-rich repeat 354..381 CDD:275380 8/27 (30%)
LRR 5. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 381..402 8/20 (40%)
leucine-rich repeat 382..405 CDD:275380 7/22 (32%)
LRR 6. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 405..426 8/38 (21%)
leucine-rich repeat 406..451 CDD:275380 10/65 (15%)
LRR 7. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 427..447 3/22 (14%)
PLN00113 445..>614 CDD:215061 53/254 (21%)
LRR 8. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 451..472 4/20 (20%)
leucine-rich repeat 452..474 CDD:275380 5/21 (24%)
LRR 9. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 474..495 4/21 (19%)
leucine-rich repeat 475..498 CDD:275380 4/22 (18%)
LRR 10. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 498..519 10/46 (22%)
leucine-rich repeat 499..549 CDD:275380 20/133 (15%)
LRR 11. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 549..570 6/20 (30%)
leucine-rich repeat 550..572 CDD:275380 7/21 (33%)
LRR 12. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 572..594 11/21 (52%)
LRR 13. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 596..617 5/21 (24%)
P-loop containing Nucleoside Triphosphate Hydrolases 639..821 CDD:476819 59/220 (27%)
COR 844..1036 CDD:406489 66/238 (28%)
STKc_LRRK1 1248..1523 CDD:270969 110/302 (36%)
WD 1. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1539..1579 5/40 (13%)
WD 2. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1582..1622 6/39 (15%)
WD 3. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1623..1668 9/44 (20%)
WD 4. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1693..1729 12/49 (24%)
WD 5. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1730..1778 5/47 (11%)
WD 6. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1779..1949 21/80 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1788..1810 6/24 (25%)
WD40 loop, involved in dimer stabilization. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821 1791..1907 18/65 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1841..1899 7/15 (47%)
WD 7. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1951..1987
LrrkNP_001262772.1 ANKYR 78..>287 CDD:440430
ANK repeat 146..177 CDD:293786
ANK repeat 179..209 CDD:293786
ANK repeat 361..390 CDD:293786 7/30 (23%)
Ank_2 364..465 CDD:463710 34/146 (23%)
ANK repeat 406..435 CDD:293786 13/49 (27%)
ANK repeat 437..464 CDD:293786 8/48 (17%)
LRR <544..>768 CDD:443914 60/233 (26%)
leucine-rich repeat 547..569 CDD:275380 8/22 (36%)
leucine-rich repeat 570..595 CDD:275380 8/25 (32%)
leucine-rich repeat 596..618 CDD:275380 8/21 (38%)
leucine-rich repeat 619..641 CDD:275380 8/27 (30%)
leucine-rich repeat 642..676 CDD:275380 12/35 (34%)
leucine-rich repeat 677..730 CDD:275380 6/52 (12%)
leucine-rich repeat 731..754 CDD:275380 5/22 (23%)
LRR_8 855..933 CDD:404697 13/82 (16%)
leucine-rich repeat 855..901 CDD:275380 2/50 (4%)
LRR_4 900..941 CDD:463713 15/45 (33%)
leucine-rich repeat 902..924 CDD:275380 7/21 (33%)
leucine-rich repeat 925..949 CDD:275380 11/23 (48%)
P-loop containing Nucleoside Triphosphate Hydrolases 993..1211 CDD:476819 59/222 (27%)
COR 1230..>1393 CDD:406489 56/166 (34%)
STKc_LRRK 1801..2095 CDD:270902 110/303 (36%)
Blue background indicates that the domain is not in the aligned region.

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