DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRK1 and Lrrk1

DIOPT Version :10

Sequence 1:	NP_078928.3	Gene:	LRRK1 / 79705	HGNCID:	18608	Length:	2015	Species:	Homo sapiens
Sequence 2:	XP_006540901.1	Gene:	Lrrk1 / 233328	MGIID:	2142227	Length:	2015	Species:	Mus musculus

Alignment Length:	2015	Identity:	1772/2015 - (87%)
Similarity:	1869/2015 - (92%)	Gaps:	4/2015 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRG 65
            |||..||..|:  ..|..:.::...:..:.: ||.|.|.|.|..||....:....|.|..||::.
Mouse     5 MAGGPQRYRSL--LTGAFQDSLPNPQPCDVM-GAEDMGSKLSLPGGSSTVQCPSMEEIHTAYKQR 66

Human    66 DRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYF 130
            :...|||||...|::..|..||||||||.||:||||.|::||:::.|||||||||||||||||:|
Mouse    67 NLSRARDLLRGVCEESESSQEKGQLLSIAAAHGDLETVQFLLTEKRVELPTEPTDDNPAVVAAHF 131

Human   131 GHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVR 195
            ||..||:||||||||||:||||||||||||||||||.||||||||||||||:|||||||||||||
Mouse   132 GHAEVVRELLESLPGPCTPQRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVR 196

Human   196 LPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTALRVKW 260
            ||||||||:|||||||||||||||||||||||||:||||||||||||||.||||||||.||||||
Mouse   197 LPLYAAIKAGNEDIAIFLLRHGAYFCSYILLDSPEPSKHLLRKYFIEASALPSSYPGKIALRVKW 261

Human   261 SHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDE 325
            |||:|||||||||:||||||||||||||||.:|||:||||||||:|||||:|.|||||.||||||
Mouse   262 SHLKLPWVDLDWLLDISCQITELDLSANCLPSLPSIIPWGLINLKKLNLSNNQLGELPCVQSSDE 326

Human   326 IICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDN 390
            |||||||||||||||||||||||||||||||||||||.||:||||||||||||||||||||::||
Mouse   327 IICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNYLERLFEEENATNWIGLRKLQELDLADN 391

Human   391 KLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLKDV 455
            :|||||..|:||||||.||||||||||.|||||:|||||||||:||||.||||||||||:||:|.
Mouse   392 RLTELPVQFMHSFKSLTSLNVSRNNLKSFPDPWSCPLKCCKASKNALESLPDKMAVFWKSHLRDA 456

Human   456 DFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKR 520
            |||||:||||||||||||||||||||||||.:|||||||||.|||||||||||||||||||||||
Mouse   457 DFSENSLKEVPLGLFQLDALMFLRLQGNQLLSLPPQEKWTCTQLKTLDLSRNQLGKNEDGLKTKR 521

Human   521 IAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLR 585
            |:.||||||||||||.||:||||||||||||||||||||||.|||||||||:|||||||||||||
Mouse   522 ISLFTTRGRQRSGTETASMLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYLGNNPGLR 586

Human   586 ELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQG 650
            ||||||||||||||||.|||.|||||||::||||||.||:|||||||||||||||||:|||||||
Mouse   587 ELPPELGQLGNLWQLDIEDLNISNVPAEVRKEGPKATLSFLRAQLRKAEKCKLMKMILVGPPRQG 651

Human   651 KSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFT 715
            |||||||||||:|||:.|.|||||||||||||||||:||||||||||||||||||||||||||||
Mouse   652 KSTLLEILQTGKAPQLAHSEATIRTTKWELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFT 716

Human   716 DKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   717 DKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA 781

Human   781 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPR 845
            |||||||||||||||||||||||||||:||||||||||||||||:|||||||||||:||||||||
Mouse   782 LCRSPSGSRATGFPDITFKHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPR 846

Human   846 SYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFP 910
            ||:||||||||||||||..|.|||||||||:|||||||.||||||||||||||||||||||||||
Mouse   847 SYISLQEAVLAEQQRRSLGDQVQYLTDRQLDQLVEQTPGNDIKDYEDLQSAISFLIETGTLLHFP 911

Human   911 DTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFL 975
            |||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||
Mouse   912 DTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIQAEDLRMLLVGTGFTQQTEEQYFQFL 976

Human   976 AKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLA 1040
            |||||||||||||||||||||||||||||.||||.||||||||||||||||||||||||||||||
Mouse   977 AKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVPVGFWQRFIARMLISLA 1041

Human  1041 EMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSD 1105
            |||||||||||||||||||||||||||:||||||||||:||||||||||||||||||||||||||
Mouse  1042 EMDLQLFENKKNTKSRNRKVTIYSFTGSQRNRCSTFRVRRNQTIYWQEGLLVTFDGGYLSVESSD 1106

Human  1106 VNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCET 1170
            ||||||||||:||:||||:|||||||||||||||||||||||||||||||||||||||||||||.
Mouse  1107 VNWKKKKSGGIKIICQSEMRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCEA 1171

Human  1171 AWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLEN 1235
            :||||.||:|:||.|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1172 SWAQHADPNERSESVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLEN 1236

Human  1236 SKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKN 1300
            |||||:|.|.|:|||||||||||:||||||||||||||||||||.||.|||||||||||.|||||
Mouse  1237 SKLEHTEGENSILGQGGSGTVIYQARYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKN 1301

Human  1301 FSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQK 1365
            ||:|||||||||||||||||:||||||||||||||||||.||||||||||:||||:|||||||||
Mouse  1302 FSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQK 1366

Human  1366 IAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGY 1430
            ||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||||||
Mouse  1367 IAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSAKEHINIKLSDYGISRQSFHEGALGVEGTPGY 1431

Human  1431 QAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRL 1495
            ||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||.||
Mouse  1432 QAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFHRL 1496

Human  1496 QALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR 1560
            |||||||||||||||||||||||||||||||||||.|.||||:||||||.|||||||||||||||
Mouse  1497 QALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSAFFSSQSQEYTVVFWDGKEESR 1561

Human  1561 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPA 1625
            |||||||||||:|||||.|||||:||||:||.|:|.||||||||||:|||||||:.|||||||||
Mouse  1562 NYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWIATEDQKIYIYSLKGMCPLSVPQQALDTPA 1626

Human  1626 VVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIADEDARQNP 1690
            |||||||||||||||:||||||||||||||||.|||||:|||||||||||||||.|.||||||||
Mouse  1627 VVTCFLAVPVIKKNSFLVLAGLADGLVAVFPVARGTPKESCSYLCSHTANRSKFCIPDEDARQNP 1691

Human  1691 YPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVVCSSEGRGEEVVWCLD 1755
            ||||||||||||||||||||||||||||..|:|.||||||.|||||||:||||:.||||:|||||
Mouse  1692 YPVKAMEVVNSGSEVWYSNGPGLLVIDCTILDISRRLEPYAAPSMVTSLVCSSDCRGEEMVWCLD 1756

Human  1756 DKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMY 1820
            ||||.||||||.|||||||||||.|:||||.|.|:|...|.| .||....|.|..:.||||||||
Mouse  1757 DKANCLVMYHSATYQLCARYFCGDPNPLRDTFSVQPSVLETP-GSHKTTSKGPVEECIADVSIMY 1820

Human  1821 SEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPG 1885
            |||||||||.||:||||||||||||||||.|..|||||||||..|.||||||.:.||||.|..|.
Mouse  1821 SEELGTQILTHQDSLTDYCSMSSYSSSPPHQDPRSPSSLPSSLTSYSSVPFSANYEDSDRLQEPS 1885

Human  1886 AASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEKDSGAQRGRVIAVLKA 1950
            ..|||:||||:|||||||||||||||:|||:|||||||.|||:||||||||||||||||||||||
Mouse  1886 VTSDRTEHDLSPMDGETFSQHLQAVKVLAVKDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKA 1950

Human  1951 RELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR 2015
            |||..|||||||||||||||||:|.||||||||||||||||||||||||||||||||||||||||
Mouse  1951 RELNRHGVLVDAAVVAKDTVVCSFANENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR 2015

Human 2016 2015
Mouse 2016 2015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRK1	NP_078928.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..56		8/29 (28%)
		ANK 1. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	51..81		10/29 (34%)
		ANKYR	58..>218	CDD:440430	124/159 (78%)
		ANK 2. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	86..116		20/29 (69%)
		ANK 3. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	119..148		24/28 (86%)
		ANK 4. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	152..182		28/29 (97%)
		ANK repeat	156..186	CDD:293786	27/29 (93%)
		ANK repeat	188..218	CDD:293786	28/29 (97%)
		ANK 5. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	193..222		27/28 (96%)
		LRR	<279..>517	CDD:443914	210/237 (89%)
		LRR 1. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	279..300		17/20 (85%)
		leucine-rich repeat	281..303	CDD:275380	18/21 (86%)
		LRR 2. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	303..324		16/20 (80%)
		leucine-rich repeat	304..330	CDD:275380	21/25 (84%)
		LRR 3. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	330..351		20/20 (100%)
		leucine-rich repeat	331..353	CDD:275380	21/21 (100%)
		LRR 4. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	353..374		18/20 (90%)
		leucine-rich repeat	354..381	CDD:275380	24/26 (92%)
		LRR 5. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	381..402		14/20 (70%)
		leucine-rich repeat	382..405	CDD:275380	16/22 (73%)
		LRR 6. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	405..426		17/20 (85%)
		leucine-rich repeat	406..451	CDD:275380	39/44 (89%)
		LRR 7. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	427..447		17/19 (89%)
		PLN00113	445..>614	CDD:215061	153/168 (91%)
		LRR 8. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	451..472		17/20 (85%)
		leucine-rich repeat	452..474	CDD:275380	18/21 (86%)
		LRR 9. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	474..495		18/20 (90%)
		leucine-rich repeat	475..498	CDD:275380	20/22 (91%)
		LRR 10. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	498..519		20/20 (100%)
		leucine-rich repeat	499..549	CDD:275380	45/49 (92%)
		LRR 11. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	549..570		19/20 (95%)
		leucine-rich repeat	550..572	CDD:275380	20/21 (95%)
		LRR 12. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	572..594		20/21 (95%)
		LRR 13. /evidence=ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06	596..617		16/20 (80%)
		P-loop containing Nucleoside Triphosphate Hydrolases	639..821	CDD:476819	174/181 (96%)
		COR	844..1036	CDD:406489	182/191 (95%)
		STKc_LRRK1	1248..1523	CDD:270969	261/274 (95%)
		WD 1. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06, ECO:0007744\|PDB:8FAC	1539..1579		37/39 (95%)
		WD 2. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06, ECO:0007744\|PDB:8FAC	1582..1622		31/39 (79%)
		WD 3. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06, ECO:0007744\|PDB:8FAC	1623..1668		41/44 (93%)
		WD 4. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06, ECO:0007744\|PDB:8FAC	1693..1729		31/35 (89%)
		WD 5. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06, ECO:0007744\|PDB:8FAC	1730..1778		40/47 (85%)
		WD 6. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06, ECO:0007744\|PDB:8FAC	1779..1949		126/169 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1788..1810		8/21 (38%)
		WD40 loop, involved in dimer stabilization. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821	1791..1907		81/115 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1841..1899		40/57 (70%)
		WD 7. /evidence=ECO:0000269\|PubMed:37558661, ECO:0000269\|PubMed:37857821, ECO:0007744\|PDB:8E05, ECO:0007744\|PDB:8E06, ECO:0007744\|PDB:8FAC	1951..1987		31/35 (89%)
Lrrk1	XP_006540901.1	ANKYR	59..>219	CDD:440430	124/159 (78%)
		ANK repeat	92..120	CDD:293786	18/27 (67%)
		ANK repeat	149..187	CDD:293786	34/37 (92%)
		ANK repeat	189..219	CDD:293786	28/29 (97%)
		LRR	<265..>518	CDD:443914	223/252 (88%)
		leucine-rich repeat	282..304	CDD:275380	18/21 (86%)
		leucine-rich repeat	305..331	CDD:275380	21/25 (84%)
		leucine-rich repeat	332..382	CDD:275380	47/49 (96%)
		leucine-rich repeat	355..378	CDD:275380	20/22 (91%)
		leucine-rich repeat	383..406	CDD:275380	16/22 (73%)
		leucine-rich repeat	407..452	CDD:275380	39/44 (89%)
		leucine-rich repeat	453..475	CDD:275380	18/21 (86%)
		LRR	<469..>617	CDD:443914	135/147 (92%)
		leucine-rich repeat	476..499	CDD:275380	20/22 (91%)
		leucine-rich repeat	500..550	CDD:275380	45/49 (92%)
		leucine-rich repeat	551..573	CDD:275380	20/21 (95%)
		P-loop containing Nucleoside Triphosphate Hydrolases	640..822	CDD:476819	174/181 (96%)
		COR	845..1037	CDD:406489	182/191 (95%)
		STKc_LRRK1	1249..1524	CDD:270969	261/274 (95%)

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DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRK1 and Lrrk1

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.