DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRRK1 and lrk-1

DIOPT Version :10

Sequence 1:NP_078928.3 Gene:LRRK1 / 79705 HGNCID:18608 Length:2015 Species:Homo sapiens
Sequence 2:NP_492839.4 Gene:lrk-1 / 172995 WormBaseID:WBGene00003068 Length:2393 Species:Caenorhabditis elegans


Alignment Length:2400 Identity:549/2400 - (22%)
Similarity:895/2400 - (37%) Gaps:717/2400 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    91 LSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESLP----------- 144
            |.|....|.:|:||:||......|.:..:.|.....|....:..|:|..||..|           
 Worm   202 LLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVLQLCLEKFPQLVKSTNNEGS 266

Human   145 ------GPCSPQR----LLN------------------WMLA---------------LACQRGHL 166
                  ..|....    :||                  :.||               ||...|||
 Worm   267 TCLHWAARCGSSECVSTILNFPFPSEFIIEIDTVGAPAYQLALDVNEVDGECRTAMYLAVAEGHL 331

Human   167 GVVKLLV--------------------LTHGADPESYAVRKNEFPVI---------VRLPL---- 198
            .|||.:.                    .|.|..|...|......|::         |.|||    
 Worm   332 EVVKAMTDFKCTSIDGRQRCPFQLDVYCTRGRTPFMLAAFNQNLPLMTLLLDAGADVNLPLAVLD 396

Human   199 --YA--------------AIKSGNEDIAIFLLRHGAYFCSYILLDSPD---------PSKHLLRK 238
              |:              |::|....|..|||..||       ||:.:         .::.|:|.
 Worm   397 TEYSVEEGRCIGSGALVEAVRSDGLHIVHFLLDRGA-------LDTDNKALRLAAQGKNEKLIRV 454

Human   239 YFIE---ASP--------------------LPSSYPGKTALRVKWSHLRLPWVDLDWLIDIS--- 277
            :.:.   |.|                    ||||.....|.::.|:...|..:..||.:..:   
 Worm   455 FLVRLVFADPEYKINKKNIDVGQIQVGQSLLPSSLCPSKAAQLNWNSANLEQLQSDWFVAAALHV 519

Human   278 -----------CQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRL 331
                       ..||.:|||.|.|.|.||:: :.:.:||.|||:||.:.:   ::.....|.|..
 Worm   520 NPRLRTTRLSLAAITRVDLSDNRLNTFPSIL-FQMPSLRSLNLADNSIRK---IEIPTYYISSTS 580

Human   332 LEI-DISSNKLSHLPPGFL-HLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTE 394
            ||| ::.:|:|..:...|| .|.:||:|..|||.|.:|.|    ..|: ...|:||:.|.|:|:.
 Worm   581 LEILNLRNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPE----YIWL-CPALKELNASYNRLST 640

Human   395 LPALFLHSFKSLNSLNVSRNNLK-----------VFPDP-------------WACPLKCCKASRN 435
            ||.:...|......||.|.||..           |..||             |...:...|...:
 Worm   641 LPMVARASRGERPRLNNSNNNFNTQSPTQESNPIVVDDPPNVTSNPLRRQNVWQASINLSKVDDD 705

Human   436 ALECLPDKMAVFWKNHLKDVDFSENALKEVPLGL-FQLDALMFLRLQGNQLAALPPQEKWTC--R 497
            :|  .|| ..|...|.|..::.|.|.....|..| .....|:.|.:..|.:.:|||.   .|  .
 Worm   706 SL--FPD-FPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLILNMSNNSMTSLPPM---ACVPA 764

Human   498 QLKTLDLSRNQL----------------------------------------------------- 509
            .|:|||||.|::                                                     
 Worm   765 HLRTLDLSYNKIQESFIEASPLHVVCHAVPPTTSNGSMLPKRRNSPARQHRSRSKSAVRSQRSLS 829

Human   510 ----------GKNEDG-----------LKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVL 553
                      .|.|:.           |||.::|  ..|.|..|.|.|||.:..||     |.|:
 Worm   830 VSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLA--GNRLRSISVTNAASKVLLPA-----LNVM 887

Human   554 CLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAE--IQK 616
            .::||.|...||.|..|..||.|.|..|..::||||:.|.|..||.|..:..::.. |.|  :..
 Worm   888 DISDNKLLQAPPDVARLTLLSMLNLSGNTAIKELPPDYGMLSRLWSLSLKGCSLKE-PLESMVNV 951

Human   617 EGPKA--MLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEIL--QTGRAPQVVHGE-ATIRTT 676
            |..|.  :::||:..|.:::....::::|:|....|||.:.:.|  :..:..|.:|.| ..||..
 Worm   952 ENCKTVEIVAYLKTILEESKTYHHLRLMILGSDGVGKSVIWDALCKEAVQKRQPIHSETGVIRQA 1016

Human   677 KW--ELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFW 739
            :|  |.:|..|.: .:..|.|:|.|.||.....:.:|.|.:.::|.:|:|.:..|:||:|.|..|
 Worm  1017 EWKFEAKRSKGDK-NLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALAQLDTW 1080

Human   740 LLNIEAKAPNAVVLVVGTHL---------------DLIEAKFRVERIATLRAYVLALCRSPSGSR 789
            |:||.|:|||:.|::|||:|               |::|.|.|..       |::|      .:.
 Worm  1081 LVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVRTR-------YMVA------DAD 1132

Human   790 ATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSL---- 850
            .:|.|.|....|  |:..|....:.|...|:.....::     :|.:|...:.||.||::|    
 Worm  1133 KSGLPRIVDVIL--INSTSRNDVKALLNTIYRTAWEVR-----MGKERAMEQQIPSSYIALMKVT 1190

Human   851 -----------QEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETG 904
                       |.||:..:..|.|      :..|.:.:......| ||:.|    :|.:||.:.|
 Worm  1191 KELGVEFRKEGQPAVMTVEAYRER------VKKRMISKFGRPFRD-DIEFY----AACTFLHDCG 1244

Human   905 TLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGT-------- 961
            .|:.|.|.:  ||:|.|:||:||:|.|..:.            ::|:.:|...|:.|        
 Worm  1245 ELVRFEDAT--LRDLIFVDPLWLAEFLTSVV------------ILRSPNLPAGLLSTDAINPHTR 1295

Human   962 ----GFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLL--------------------------- 995
                |.....:.|....|.|||:||.......|:|.||                           
 Worm  1296 SFKSGALLMLKTQLLDLLHKFELALATQPRQLLIPSLLPDEYRLRSDFLASAVKIRMKMSQWNVR 1360

Human   996 -PSKPGLDTHGMRHPTANT---------------------IQRVFKMSFVPVGFWQRFIARMLIS 1038
             ||..|..|......|:.|                     ::|::.::::|.|||.|.:.|::  
 Worm  1361 CPSPAGSPTKSPLRRTSPTDQNGVGSEDVMLQFTYDDDQLLRRIYALAYIPSGFWSRLVTRIV-- 1423

Human  1039 LAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVK--RNQTIYWQEGLLVTFDGGYL-- 1099
                      ..||..:...  :|:..|...|.:.:....|  :.:.:.||.|:.:...|..|  
 Worm  1424 ----------GDKNVCAAIE--SIFMTTSADRAKIADIATKHAKAEWVVWQTGIELHVKGHSLFT 1476

Human  1100 -----------SVESSDVNWKKK------------------------------KSGGMKIVCQSE 1123
                       .::.|.::.:.|                              ...|.|:..:::
 Worm  1477 LKQFLPLAEVRDIDYSAIDMRAKDEQKRWRTWNQPSHRPIVEMVVNSLSISAASQHGRKLSMKTD 1541

Human  1124 VRDFS-AMAFITDHVNSLIDQWFPALTAT---ESDGTPLMEQYVPCPVC------------ETAW 1172
            |...| .:|.|:|.:::|::.|:|||...   .|:|..|:.:||.||.|            .::.
 Worm  1542 VEGRSRLLAMISDLLDTLLEDWYPALGTRFVHSSEGDLLVSRYVLCPQCVRDAERNGSRSRTSSS 1606

Human  1173 AQHTDPSEKSED----------------------------VQYFDMEDCVLTAIERDFISCPRHP 1209
            |.|    .:|:|                            |..|.:|:|:|...|.:::.||.|.
 Worm  1607 ASH----RRSQDDGELPITSSSHMKGSRTTGDISKCRGGVVHCFVIEECMLAGREYNWVECPSHG 1667

Human  1210 DLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQP------VA 1268
            .|  .::||.|:....|....|.:...:|:.|.    :||:|..| .::||..: ||      ||
 Worm  1668 GL--HMRELAPDTVFADIENALTIHPDQLKRSR----MLGRGAFG-FVFRATVR-QPNGELCEVA 1724

Human  1269 VKRFHIKKFKNFANVPAD--------TMLRHLRATDAMKNFS-EF--------RQEASMLHALQH 1316
            .|...          |.|        .:..:..|.|..|..| ||        |||.|:|..::|
 Worm  1725 QKMLE----------PVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKH 1779

Human  1317 PCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKN 1381
            |.::.|:|:...||...:|||||.:||.:|..:.:..:.:.||  :.::.|.|:|..|.|||..:
 Worm  1780 PNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLG--VIKESAVQVARALEYLHSAH 1842

Human  1382 IIFCDLKSDNILVWSLDV----KEHINIKLSDYGISRQSFHE-GALGVEGTPGYQAPEI---RPR 1438
            ||:.||||:|:|.|....    :..:.:||.||||||..... ||.|..||.|:.||||   ...
 Worm  1843 IIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGE 1907

Human  1439 IVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECW 1503
            ..|.:|||.||:||.|||||:.:.|.  ..:..:.:::..|.||||...|.:....:..|::.||
 Worm  1908 EEYTQKVDCFSFGMFLYELLTLKFPF--ESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCW 1970

Human  1504 DTKPEKRPLALSVVSQMKDPTFATFMYELC-CGK---QTAFFS-------SQGQEYTVVFW-DGK 1556
            ...||.||.:..:|.....|.| |.:.::| .|:   .|...:       ....::....| .|:
 Worm  1971 SAHPESRPSSSQLVGFCAAPEF-THLLDVCELGEALPPTQLMAVGITDEIDDPDDFEAQLWLSGR 2034

Human  1557 EESRNYTVVN-TEKGLMEVQRMCCP--GMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQ 1618
            |    ..|:. |:.|.::.:.:..|  |..||   :|:.|:|:..|..::.:|   |:....|..
 Worm  2035 E----MVVMGCTQYGFVDQKSIELPHRGKYVS---KVRDSVWSCDECGQVTVY---GISLHETGH 2089

Human  1619 QALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFSIAD 1683
              |..|::....:..|.:..|..|:|  ::|..:.:..:   :..:|.|:|              
 Worm  2090 --LQLPSLNGTLICAPELISNDVLIL--ISDKQIVLLKL---SESNSVSHL-------------- 2133

Human  1684 EDARQNPYPVKAMEVVNSGS--EVWYSNGPGLLVI-DCASLEICRRLEPYMAPS---MVTSVVCS 1742
             ....:||.::....:.:||  ::|..:..|.:.| ..||.:..........|.   :|..:|.|
 Worm  2134 -GTIDSPYEIRTATFLGNGSTRQIWAGHSEGRISIHHIASNDSFSFSSSLYLPDDKCIVRQLVGS 2197

Human  1743 SEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFP----VRPLDTEPPAASHTA 1803
            .:.   :.||...:|::.:.|......|:....      .:|.:.|    :..:|.|..:.::..
 Worm  2198 KDA---QKVWIALEKSSKVQMVEVEKRQVTGSL------DIRKVMPGSETIHTIDMEMASQNYVT 2253

Human  1804 NPKVPE---GDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLPSSPAS 1865
            ...:.|   ||     .:......|..::.|..:|            .|..|.|           
 Worm  2254 CIGLLERNDGD-----QLYIGTSKGLLVIAHATTL------------QPLSACR----------- 2290

Human  1866 SSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIWVPRRGGDVIV 1930
                ||..|.....:|..|....:.:....|.:...:....|.           ||..|..:  .
 Worm  2291 ----PFEGDITSICILEEPSREEENTRGKATTLSTASSESGLG-----------WVRERVSE--T 2338

Human  1931 IGLEKDSGA---QRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTEWCLAVWR 1987
            :...:.|.|   .:|..:.|...|:...    :....||::.:...:.       :||||
 Worm  2339 VDRFRSSPATVETQGAALVVCIGRQFRS----LSHRFVAEEKLADVYS-------IAVWR 2387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK1NP_078928.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..56
ANK 1. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 51..81
ANKYR 58..>218 CDD:440430 45/229 (20%)
ANK 2. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 86..116 9/24 (38%)
ANK 3. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 119..148 7/45 (16%)
ANK 4. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 152..182 15/82 (18%)
ANK repeat 156..186 CDD:293786 14/64 (22%)
ANK repeat 188..218 CDD:293786 12/58 (21%)
ANK 5. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 193..222 13/57 (23%)
LRR <279..>517 CDD:443914 82/340 (24%)
LRR 1. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 279..300 10/20 (50%)
leucine-rich repeat 281..303 CDD:275380 9/21 (43%)
LRR 2. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 303..324 7/20 (35%)
leucine-rich repeat 304..330 CDD:275380 8/25 (32%)
LRR 3. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 330..351 7/22 (32%)
leucine-rich repeat 331..353 CDD:275380 8/23 (35%)
LRR 4. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 353..374 9/20 (45%)
leucine-rich repeat 354..381 CDD:275380 10/26 (38%)
LRR 5. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 381..402 8/20 (40%)
leucine-rich repeat 382..405 CDD:275380 9/22 (41%)
LRR 6. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 405..426 9/44 (20%)
leucine-rich repeat 406..451 CDD:275380 14/68 (21%)
LRR 7. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 427..447 4/19 (21%)
PLN00113 445..>614 CDD:215061 61/247 (25%)
LRR 8. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 451..472 5/21 (24%)
leucine-rich repeat 452..474 CDD:275380 5/22 (23%)
LRR 9. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 474..495 6/20 (30%)
leucine-rich repeat 475..498 CDD:275380 7/24 (29%)
LRR 10. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 498..519 11/94 (12%)
leucine-rich repeat 499..549 CDD:275380 22/123 (18%)
LRR 11. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 549..570 8/20 (40%)
leucine-rich repeat 550..572 CDD:275380 9/21 (43%)
LRR 12. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 572..594 10/21 (48%)
LRR 13. /evidence=ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06 596..617 5/22 (23%)
P-loop containing Nucleoside Triphosphate Hydrolases 639..821 CDD:476819 58/201 (29%)
COR 844..1036 CDD:406489 60/267 (22%)
STKc_LRRK1 1248..1523 CDD:270969 102/305 (33%)
WD 1. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1539..1579 6/48 (13%)
WD 2. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1582..1622 9/39 (23%)
WD 3. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1623..1668 7/44 (16%)
WD 4. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1693..1729 7/38 (18%)
WD 5. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1730..1778 9/50 (18%)
WD 6. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1779..1949 27/179 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1788..1810 4/28 (14%)
WD40 loop, involved in dimer stabilization. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821 1791..1907 17/118 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1841..1899 9/57 (16%)
WD 7. /evidence=ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821, ECO:0007744|PDB:8E05, ECO:0007744|PDB:8E06, ECO:0007744|PDB:8FAC 1951..1987 5/35 (14%)
lrk-1NP_492839.4 ANKYR 13..337 CDD:440430 29/134 (22%)
ANK repeat 56..88 CDD:293786
ANK repeat 90..121 CDD:293786
ANK repeat 197..228 CDD:293786 9/25 (36%)
ANK repeat 230..262 CDD:293786 7/31 (23%)
ANK repeat 361..390 CDD:293786 5/28 (18%)
Ank_2 366..472 CDD:463710 21/112 (19%)
ANK repeat 398..432 CDD:293786 7/33 (21%)
LRR <529..>778 CDD:443914 80/263 (30%)
leucine-rich repeat 534..555 CDD:275380 9/21 (43%)
leucine-rich repeat 556..580 CDD:275380 9/26 (35%)
leucine-rich repeat 581..604 CDD:275380 8/22 (36%)
leucine-rich repeat 605..627 CDD:275380 10/26 (38%)
leucine-rich repeat 628..654 CDD:275380 9/25 (36%)
leucine-rich repeat 655..684 CDD:275380 8/28 (29%)
leucine-rich repeat 687..718 CDD:275380 6/33 (18%)
leucine-rich repeat 719..742 CDD:275380 5/22 (23%)
leucine-rich repeat 743..765 CDD:275380 7/24 (29%)
leucine-rich repeat 803..856 CDD:275380 2/52 (4%)
LRR <857..>953 CDD:443914 38/103 (37%)
leucine-rich repeat 857..883 CDD:275380 11/27 (41%)
leucine-rich repeat 884..906 CDD:275380 9/21 (43%)
leucine-rich repeat 907..931 CDD:275380 11/23 (48%)
P-loop containing Nucleoside Triphosphate Hydrolases 977..1160 CDD:476819 57/198 (29%)
COR <1239..>1336 CDD:406489 32/110 (29%)
Protein Kinases, catalytic domain 1699..1990 CDD:473864 102/306 (33%)
Blue background indicates that the domain is not in the aligned region.

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