Protein Alignment SMC6 and SMC2

DIOPT Version :10

• Sequence 1: XP_011531409.1
• Gene: SMC6 / 79677
• HGNCID: 20466
• Length: 1110
• Species: Homo sapiens
• Sequence 2: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Alignment Length: 1270
• Identity: 267/1270 - (21%)
• Similarity: 491/1270 - (38%)
• Gaps: 339/1270 - (26%)

Human    67 FGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFV-KDGQ---NSADISITLRN-- 125
            |......:.|.||||||.:|.::...||...:...|.|:|:..| |:||   ..|.::|...|
  Fly    23 FDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNTN 87

Human   126 -----RGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHF---NIQV 182
                 :|.:..:      .|.:.:.:.:.|...:.:   .|.:|..:|     :.|.|   .:.|
  Fly    88 PAQCPQGYEKCR------EISVTRQVVVGGKNKFLI---NGKLVQNKK-----VQDFFCSIQLNV 138

Human   183 DNPVSVLTQEMSKQFL--------------------QSKNEGDKYKFFMKATQLEQMK------- 220
            :||..::.|...:|.|                    ::|.:..|.....|.|::.:.|
  Fly   139 NNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEEV 203

Human   221 --------------EDYSYI-------------------METKERTKEQIHQGEERLTELKRQCV 252
                          ::|..|                   .||.:..:...|:.|:|:...|....
  Fly   204 LPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHA 268

Human   253 EKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIR--DNIKIGEDRAARLDRKMEEQQ 315
            :.....:||.  :::|...:.:..||..::.| :|.||:|.|  :....|..:||:...:.:|::
  Fly   269 KNLAEVESIE--NSVKEMQQQIDAEMGGSIKN-LETQLSAKRALEATATGSLKAAQGTIQQDEKK 330

Human   316 VRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKD 380
            :|:..     |:|:|         :.||          :|||.| :.|:|     ..|:::||:.
  Fly   331 IRMAS-----KNIED---------DERA----------LAKKEA-DMAKV-----QGEFESLKEA 365

Human   381 DEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEH 445
            |.:..|..|               :.|||:..:.:.:...:|.|.|..|  ||...|.|:..|..
  Fly   366 DARDSKAYE---------------DAQKKLEAVSQGLSTNENGEASTLQ--EQLIVAKEQFSEAQ 413

Human   446 GKIKREELDVKHALSYNQRQLKE--------LKDSKT-DRLKRFGPNVPALLEAIDDAYRQGHF- 500
            ..||..|::::|.....:::..|        :||.|. |:|.....|:...|:::|  |..|||
  Fly   414 TTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLD--YEGGHFE 476

Human   501 ----------------------------------------TYKPVGPLGACIHLRDPELALAIES 525
                                                    ..|..|.:|....::|.:.::|:..
  Fly   477 KLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQ 541

Human   526 CLKGLLQAYCCHNH-ADERVLQA--LMKRFYLPGTSRPPIIVSEF------RNEIYDVRHRAAYH 581
            ...|.|.:|...:. ..:::||.  |.:|..|       |.:::.      ||.:...:::..
  Fly   542 TAGGSLYSYVTDDDVTSKKILQRGNLQRRVTL-------IPINKIQSGSLNRNVVEYAQNKVG-- 597

Human   582 PDFPTVLTALEIDNAVVANSLIDM-RGIETV--------LLIKNNSVARAVMQSQKPPKNCREAF 637
                       .:|...|.||||. |..|.|        |:.|:..||:.:  |..|..||| :.
  Fly   598 -----------AENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQI--SYDPRINCR-SV 648

Human   638 TADGD------QVFAGRYYSSENTRPKFLS--------RDVDSEISDLENEVE---------NKT 679
            |.:||      .|..|......|...:..:        |::||||:.:|.::.         ||.
  Fly   649 TLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKM 713

Human   680 AQILNLQQH-LSALEKDIKHNEELLKRCQLHYKELKMKIR---KNISEIRELENIEEHQSVDI-A 739
            .:.|:|:|| |:..|..:.  :...::.|...:|::.:::   :.|.:.||.:...:.:.||| |
  Fly   714 KENLDLRQHELTMCENRLA--QTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEA 776

Human   740 TLED-------EAQENKSKMKMVEEHMEQQKENM----EHLKSLKIEAENKYDAIKFKINQLSEL 793
            .|.|       |.....:::|:.::..|:.:.|.    :..::|::|......:|:....|..|:
  Fly   777 KLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEM 841

Human   794 ADPL---KDELNL-------ADSEVDNQKRGKRHYEEK----QKEHLDTLNKKKR--------EL 836
            .|.|   |.||:.       |.|||...::..:..::|    .||..:.|.||::        ||
  Fly   842 IDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIEL 906

Human   837 DMKEKELEEK--MSQARQICPERIE-VEKSASILDKEINRLRQKIQAEHASHGDREEI---MRQY 895
            ::|:||.|:|  .|.|:: ..:|:| :|.....:.:|.|....|......|..|..|.   :.:.
  Fly   907 EVKKKENEQKKISSDAKE-AKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKM 970

Human   896 QEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRSFRQKNKPNLYYYI------NLFQMQ 954
            ||.:      |...|||.....::.:..|..||..::.|:....:|..:...|      ...|:.
  Fly   971 QEKK------DKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLN 1029

Human   955 CLTLRCKLYFDNLLSQ--RAYCGKMNFDHKNETLSISVQPGEGNKAAFN-----DMRALSGGERS 1012
            .........|..:.|.  .....|:|..|.|..|:     |...|..||     .:..||||::|
  Fly  1030 KAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLT-----GLEIKVGFNGIWKESLGELSGGQKS 1089

Human  1013 FSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRF--RQFILLTPQSMSSL 1075
            ...:..:|::...:.:|...|||.|..:||.:.:....::     .|.|  .||::::.:.....
  Fly  1090 LVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSML-----KQHFTNSQFLIVSLKDGLFN 1149

Human  1076 PSSKLIRILRMSDPERGQTTLPFRPVTQEEDDDQR 1110
            .::.|.|.|.    |.|.:|:. |.|:::...::|
  Fly  1150 HANVLFRTLF----EEGVSTIT-RQVSRQATTNKR 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	XP_011531409.1	P-loop containing Nucleoside Triphosphate Hydrolases	48..>204	CDD:476819	36/170 (21%)
		SMC_prok_B	<215..>900	CDD:274008	180/861 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<996..1094	CDD:476819	25/104 (24%)
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	262/1250 (21%)