Protein Alignment SMC6 and glu

DIOPT Version :10

• Sequence 1: XP_011531409.1
• Gene: SMC6 / 79677
• HGNCID: 20466
• Length: 1110
• Species: Homo sapiens
• Sequence 2: NP_723996.1
• Gene: glu / 35001
• FlyBaseID: FBgn0015391
• Length: 1409
• Species: Drosophila melanogaster
• Alignment Length: 1383
• Identity: 279/1383 - (20%)
• Similarity: 523/1383 - (37%)
• Gaps: 389/1383 - (28%)

Human     4 RKEENFSSP-----KNAKRPRQEELEDFDKDG------DEDECKGTTL-------------TAAE 44
            |:...|..|     :..:..:|:|.||...|.      .:||..||.:             :...
  Fly    18 RQSGQFRVPQLTAQQQLRAQQQQEEEDAAVDALDDALIFDDEEGGTRIGDIYIPPPVPPHCSMES 82

Human    45 VG---IIESIHLKNFMCHS---MLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRA--VATN 101
            .|   ||..|..:||..::   .||||.  .:...::|.||||||.|:.:::...|.||  :...
  Fly    83 TGPRLIISKIVNRNFKSYAGEVELGPFH--QSFTAIIGPNGSGKSNVIDSMMFVFGCRANRIRCK 145

Human   102 RGSSLKGFVKDGQNSADISITLR-----NRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATG 161
            |.|:|........|....|:.:.     ::||...: .|..:||:|::....|.|..|::.....
  Fly   146 RVSTLIHSSSSYPNLRSCSVAVHFKQIVDKGDGTCE-DVPDSSIVIERTAMSDNSSYYQINDKRA 209

Human   162 SVVSTRKEELIAILDHFNIQVD-NPVSVLTQE-----MSKQFLQSKNEGDKYKFFMKATQLEQMK 220
            .:     :::..:|...::.:: |...:|..|     |.|...|::||....::      ||.:.
  Fly   210 QL-----KDVAKLLKKHHVDLEHNRFLILQGEVESIAMMKPKGQTENETGMLEY------LEDIV 263

Human   221 EDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNE 285
            ....||     |..:||:|..::||:.:   .||..|.                  ::|...:.:
  Fly   264 GTQRYI-----RPLQQINQRVDQLTDDR---TEKHNRC------------------KLAEREMKD 302

Human   286 IEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAE-QKYKDI-QDKLEKISEETNARAPECMA 348
            :|:..|...|.:            |.|.:.||..... ||...| :.|||:.::|..|.|.|...
  Fly   303 LEQPFNEAVDYL------------KKENELVRTKSFHIQKIISIKKSKLEQYTQEHEACAEELKT 355

Human   349 LKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRI------------------EELKK-- 393
            ......|.|::..|.|.:..:.:.||:||.|..||:.||:                  ::.||
  Fly   356 HDEGTAALKQSRAEKETIIRKEIEEYEALVKKREQIKKRLVTVESAYTEIQSTMENTNKQRKKDK 420

Human   394 ----STDQSLE-----PERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKD----KEEH 445
                ..::.||     ||:  .|::|....:::::.:..:.::|:|:|:.|..:.|.    .|:.
  Fly   421 AQIEKNEKELEDLHKLPEK--NQREIEDCNKKLESLEVSKVTLNEELEKQQAELTKTTAPLTEKR 483

Human   446 GKIKREELDVKHALS-------YNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYK 503
            .|:..|.:.:|..::       ..:.|||.||.::|...:::        |.:..:|.|...:.:
  Fly   484 LKLSDELVGLKEKVNTAKGEVQVFESQLKILKQAETTESRKY--------ETLKSSYEQSQKSLE 540

Human   504 P----VGPLGACIHLRDPELA---LAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPP 561
            .    |..|...|.....|:|   ..::..:|            :||.|.....:.......|..
  Fly   541 EKVTRVDELKESIPRMKTEIASKSAEVDKMVK------------EERNLSMQCNKLRTEINERSS 593

Human   562 IIVSE-FRNEIYDVRHRAAYHPDFPTVLTAL-------------------EIDNAVVANSLIDMR 606
            ::.:: ..|::.|...|.......|.:|..|                   .:||.|..|
  Fly   594 VMQAQRSNNKVLDFLMRMKMEGKIPGILGRLGDLGGIDAKYDIAISTACGRLDNIVTDN------ 652

Human   607 GIET----VLLIKNNSVARAV------MQSQKPPKNCR-----------EAFTADGDQVFAGRYY 650
             .||    :..:|..:|.||.      ::..:...|.|           :....:.|:|....|:
  Fly   653 -YETASAAIGALKEYNVGRATFITLDKIEHHRREANSRINTPENVPRLYDLVKVEDDRVRTAFYF 716

Human   651 SSENT---------------------------------------------------RPKFLSRDV 664
            :..||                                                   |.|......
  Fly   717 ALRNTLVCDDLEQGTRIAYGRERYRVVTLRGEMIEMTGTMSGGGSRPIRGKMGTQVRTKTAESAD 781

Human   665 DSEIS-----DLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKI----RKN 720
            .|:||     |::.:.|...|::...|:...:||::|:..:..|:|.:..||.|.:.|    ::.
  Fly   782 SSQISQKALEDMQIQAEELQARVNYCQEQQGSLEREIQTLKNGLQRDEAEYKRLAVSITSLEQQM 846

Human   721 ISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIK- 784
            .|.:::.| .:..:.:...|.|...:|.:.:::..::.:||.:...:.:.|...|.:|:||.::
  Fly   847 ASNLKQCE-AQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSSQIEEIQNQYDTLRN 910

Human   785 ----------FKIN-QLSELADPLKDELNL----ADSEV-------DNQKRGKRHYEEKQKEHLD 827
                      .|:| |:.:||..:: .||:    ||..:       :|.:...:..|||.|...:
  Fly   911 ESVKPVEAKIKKVNSQIEKLAANVR-SLNVGLATADRNITKITGNNNNLRENIKAAEEKLKSLNE 974

Human   828 TLNKKKRELDMKEKELEE-----------------------KMSQARQICPERIEVEKSASILDK 869
            ..||.|.:.:..|||:||                       |....|.|  ||||::........
  Fly   975 DRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEIDEITKEENKRNI--ERIEIDTKLQAAAG 1037

Human   870 EINRLRQKI---QAEHA-----------------SHGDREEIMRQYQEA---RETYLDLDSKVR- 910
            ::|:::..|   ||:.|                 ...:.||:..:..||   ::|.|:.|.|.:
  Fly  1038 KMNKVKNDIPGWQAQLAPLKLNEIPGETEPQAPLKELNEEELEAETLEALQYKQTMLEEDLKTKK 1102

Human   911 ----TLKKF----------IKLLGEIMEHRFK---TYQQFRSFRQKNKPNLYYYI-----NLFQM 953
                .:|:|          :::|.:|...|.:   .|::.|..|.|...:.:..|     .::||
  Fly  1103 PNLSCIKEFNEKRLVYLDRVRVLEDITSKRNEMRDKYEEVRKRRYKEFMDGFSIITRKLKEMYQM 1167

Human   954 QCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCF 1018
              :||......:.:.|...:...:||         :|:|   .|.::..:..|||||::.|::..
  Fly  1168 --ITLGGDAELELVDSMDPFTEGVNF---------TVRP---PKKSWKYISNLSGGEKTLSSLAL 1218

Human  1019 ILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQ-SMSSLPSSKLIR 1082
            :.:|.....||...:||.|..:|..|..|....|   .:..:..|||:::.: :|..| ::.|:.
  Fly  1219 VFALHYYKPSPLYFMDEIDAALDFKNVSIVGHYI---KERTKNAQFIIVSLRVNMFEL-ANFLVG 1279

Human  1083 ILRMSDPERGQTTLPFRP 1100
            |.::||.....|.|.:.|
  Fly  1280 IYKVSDCTDSITMLNYPP 1297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	XP_011531409.1	P-loop containing Nucleoside Triphosphate Hydrolases	48..>204	CDD:476819	41/171 (24%)
		SMC_prok_B	<215..>900	CDD:274008	171/903 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<996..1094	CDD:476819	26/98 (27%)
glu	NP_723996.1	SMC_N	89..1287	CDD:426784	262/1300 (20%)