Protein Alignment SMC6 and SMC5

DIOPT Version :10

• Sequence 1: XP_011531409.1
• Gene: SMC6 / 79677
• HGNCID: 20466
• Length: 1110
• Species: Homo sapiens
• Sequence 2: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 1198
• Identity: 260/1198 - (21%)
• Similarity: 465/1198 - (38%)
• Gaps: 354/1198 - (29%)

Human    46 GIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFV 110
            |.|.|::.|:|:.:|.: .|.....:|.:.|.||||||.:::|:|:||||..:..:|.:|:..::
  Fly    14 GRIHSVYCKDFVSYSEI-TFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77

Human   111 KDGQNSADISITLRNR---GDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSV--VSTRKEE 170
            :..:.||.|.:.:..|   ..:.|:..:..|.:                  :|.||  ..|.|:.
  Fly    78 QSNKTSATIIVRVYGRTPNTTETFRRIINSNGL------------------STFSVNDKDTSKKN 124

Human   171 LIAILDHFNIQVDNPVSVLTQEMSKQF------------LQSKNEGDKYKFFMKATQLEQMKEDY 223
            .:|.:..|||||.|....|.|:..:.|            :.|..:.|....|   ..|:||:.:.
  Fly   125 FLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSF---NSLKQMRTEQ 186

Human   224 SYIMETKERTKEQIHQGEERLTELK---RQCVEKEERFQSI----------------AGLSTMKT 269
            :.:...:|:.|..:.:.::||..|:   .|..|:||..|.:                |..:.|||
  Fly   187 ANVHANREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKT 251

Human   270 NLESLK---------HEMAWAVVNEIEKQLNAIR----DNIKIGEDRAAR---LDRKMEEQQVRL 318
            .:::.|         |:.......:|||:..::|    :..::.|:..|.   :|.||:  .::.
  Fly   252 QVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMD--SLKQ 314

Human   319 NEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRS----LNEYKALK- 378
            ...::||     :||:..:::...|.||..|  :.:.:.:.| |.|.| |:|    ::|.:..|
  Fly   315 GIYQKKY-----ELEQNIKKSRRTATECDNL--NQLVENKIY-ELETL-NKSRPLIVSELERAKE 370

Human   379 -------KDDEQLCKRIEELKKSTDQSLEPE------RLERQKKI-------------------S 411
                   |..||..:| .:|::..:..:.||      ::||.:.:                   :
  Fly   371 SCAAARGKAMEQYSRR-RQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMN 434

Human   412 WL---KERVK-----------AFQNQEN-----SVNQEIEQFQQAIEKDKEEHGKIKREELDVKH 457
            ||   |:|.|           ..||.|:     :|..:.:.|..|.| ||.:...: ..||.||.
  Fly   435 WLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACE-DKGDMSDL-INELCVKQ 497

Human   458 ALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTY---KPVGPLGACIHLRDPEL 519
            .|..|     .:..:.:|||. :.|..|     |||....|..:|   ...||:
  Fly   498 KLGVN-----VIYCAPSDRLV-YSPKTP-----IDDLRSFGFRSYLVDLVTGPI----------- 540

Human   520 ALAIESCLKGLLQAYCCHN-----HADERVLQALMK--RFYLPGTSRPPIIVSEFRNEIYDVRHR 577
                 ..:..|..:|..||     .|......::.|  |.|..|:.:..:..|.:|::
  Fly   541 -----PLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSD------- 593

Human   578 AAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGD 642
                    |:||...|.   ..|.||.:...:..|::                |.|.||...
  Fly   594 --------TILTESSIR---AKNQLITVDSQQLALVM----------------KQCSEAVKE--- 628

Human   643 QVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQ 707
                              |..:.:.|:..:||.|           .|.|:.||.:.....|.:..
  Fly   629 ------------------SDSIKNAITQTDNEFE-----------RLQAVAKDEQEKRRKLDQKI 664

Human   708 LHYKELKMKI---RKNISEIRELENIE---------EHQSVDIATLEDEAQENKSKMK-----MV 755
            .|:..||.:|   :|.:..:|..::::         .|:  |:..:.|...|..|.:|     ::
  Fly   665 AHFNSLKTEIETLQKKLEALRNSDSLDCLETNFCNSLHK--DLKKIFDADAELCSCLKAIDRLII 727

Human   756 EEHMEQQKEN---MEH---LKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQK-- 812
            |::|.|.|.:   ::|   :::|| |:|.:..|......||.:.   |::::    |:|:.:|
  Fly   728 EKNMAQTKVSIYMLQHETQIEALK-ESEEQSKAATRDFQQLLQC---LENQI----SDVNKRKSA 784

Human   813 -RGKRHYEEKQKEHLDTLNK---KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINR 873
             :|..|.|      :.|.:|   ||...:::..:|.| :.:|......|:|..||.:
  Fly   785 IQGLCHGE------IPTSSKFPFKKEFRELENIDLPE-LREAIHDFQARLECMKSVN-------- 834

Human   874 LRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRSFRQ 938
                                  .||..:|..|.::|:.|::.|:          ::..|.:|. :
  Fly   835 ----------------------SEAISSYQGLQNEVKQLEEGIQ----------ESVNQAKSI-E 866

Human   939 KNKPNLYYYINLFQ--MQCLTLRCKLYFDNLLSQRAYCGKM------NFDHKNETLSISVQPGEG 995
            ....|||   :.::  :..|.......|...:....|.|::      .:|..:..:.|.||...|
  Fly   867 SGMSNLY---DKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRG 928

Human   996 NKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQR 1060
            .:....|....|||||:.|...:.|||..:...||||:||.:..||..|.|...||:||.|....
  Fly   929 LQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHG 993

Human  1061 FRQFILLTPQSMSSLPSSKLIRILRMSD 1088
            ..|::.:||         ||:|.|..::
  Fly   994 SAQYLFVTP---------KLLRDLNYNE 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC6	XP_011531409.1	P-loop containing Nucleoside Triphosphate Hydrolases	48..>204	CDD:476819	44/172 (26%)
		SMC_prok_B	<215..>900	CDD:274008	162/814 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<996..1094	CDD:476819	32/93 (34%)
SMC5	NP_996141.2	P-loop containing Nucleoside Triphosphate Hydrolases	14..>160	CDD:476819	44/164 (27%)
		SMC_N	22..>425	CDD:481474	97/436 (22%)
		SMC_prok_B	<193..1001	CDD:274008	204/975 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<919..1025	CDD:476819	36/103 (35%)