Protein Alignment mast1a and dop

DIOPT Version :9

• Sequence 1: XP_009292706.1
• Gene: mast1a / 796739
• ZFINID: ZDB-GENE-121214-221
• Length: 1738
• Species: Danio rerio
• Sequence 2: NP_001261884.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Alignment Length: 1909
• Identity: 706/1909 - (36%)
• Similarity: 914/1909 - (47%)
• Gaps: 545/1909 - (28%)

Zfish    26 SSGCRTSNRKSLILTSTSPTL---PRPHSPLPGHIGSSPLDSPRTFSPSAPAHFSFASSRR---- 83
            |||. ..:|.||:..|.:...   .|.|||    ..:||:||||.   ::|..|:||..:|
  Fly   311 SSGV-AHHRLSLVTNSAAVAAAGGSRTHSP----YSASPVDSPRL---NSPMPFAFAPIKRIASC 367

Zfish    84 ----ADGRRWSLASLPSSGYGTNTPSSTSSS--SSQERLHQL----------------------- 119
                |||||||:||||||||||...||..||  ||||.|:||
  Fly   368 RGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCA 432

Zfish   120 -------------------------PFQPT-LDELHFLT-----------------------KHF 135
                                     |.:|| |.....:|                       .:.
  Fly   433 EHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANG 497

Zfish   136 GST-----ESITDDDGRRSPHMRPRSRSLSPGRSSSCYDNEIVMMNHVYKERFPKATAQMEERLA 195
            ||:     .|.....||.||:.||||||||....|...||||.:||.:|||||||||.||||||.
  Fly   498 GSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLK 562

Zfish   196 DFIESYSPENVLPLADG--VLSFIHHQIAELSRNCLTKSREGLITTVYFYELQENLEKLLHEAYE 258
            .||............|.  ::.|:|||:.|::|:||.||...|||:.|||||.||||:||.|..|
  Fly   563 LFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKE 627

Zfish   259 RS--ESSELTFITELVKKLFIIISRPARLLECLEFNPEEFYHLLEAAEDHAKEGQLMKADIPRYI 321
            :|  .::||..:   :|||.:||||||||||||||:|:|||.||||||.|||...::|||||:||
  Fly   628 KSPEAAAELNGV---IKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYI 689

Zfish   322 ISQLGLTRDPLEDM---------------------------------------------VNLESY 341
            |.:|||.|||:.::                                             ::..:.
  Fly   690 IHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAM 754

Zfish   342 DS--------EGPHTP-ETDDSAEGKLKAIK---------------------------------- 363
            ||        :.|.|| .|.|:|.....||.
  Fly   755 DSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAAT 819

Zfish   364 ---------PPCESDFQTIKLISNGAYGAVYLVRHRETRQRFAMKKINKQNLILRNQIQQAFVER 419
                     .|.|:||..:||||||||||||||:|:.||||||||||||.|||||||::|.|.||
  Fly   820 ATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAER 884

Zfish   420 DILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVDMARMYFAETVLALEYI 484
            |||:||:|||||||:|||||::|||:||||||||||.|||||||.||.||||.||||||||:||:
  Fly   885 DILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYL 949

Zfish   485 HNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMNLTTNLYEGHIEKDAREFLDKQVCGTPEY 549
            |:||||||||||||||||::||||||||||||||||:|.||||||:|:.:.|:|.||||.|||||
  Fly   950 HSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEY 1014

Zfish   550 IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVITDYIEWPNGDE-ALPADA 613
            ||||||||||||||||||:|||||||||:|||||||:|.||||...:.|.||||:.:: .:.|:|
  Fly  1015 IAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEA 1079

Zfish   614 QSLISSLLQTNPLVRLGT-GGAFEVKQHSFFSGLDWNGLLRQKAEFIPHLESEEDTSYFDTRSER 677
            :.:||.|||.||..|||| .||.|:|:|.:|.|:|||.||||||||:|.|..::||||||||.:|
  Fly  1080 KDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDR 1144

Zfish   678 YRH-INSYDEDDTNDDEPVEIRQFSSCSPRFSKV-YSSMEH----------------LSQL---E 721
            |.| :...|.||| ||.|| ...|:|.:|::.|. ||...|                ||.|   .
  Fly  1145 YNHDLGGEDTDDT-DDTPV-FGSFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRA 1207

Zfish   722 QKTPVVTRREHKGRRDDKITKRESFGSFSMRDKSWRTGS-------------PEMKRLSCSESL- 772
            |:||..|..........|:  :...||.|.......:||             |::::|..|.|.
  Fly  1208 QETPAATVGATSTGALPKL--KSGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCL 1270

Zfish   773 -------------------------------YMEGDCSPPMGA----RRRFSALMDTHRFASSQE 802
                                           |::   .|..||    ::|.|...:|....|:..
  Fly  1271 KVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQ---QPNPGATQRMQQRHSMPPNTTTIISTPA 1332

Zfish   803 GDGERQVTAKATGSSEGAVPPSSPSANEQRNGKEVMSISSSKSTDKASRPGEVSAPQTIPSTGAP 867
            .....|     |.::..|.||::...:..|:..|    ||...:|..|       ||.  :....
  Fly  1333 TPPPTQ-----TQATMAATPPTATVGSFSRSTPE----SSQTDSDDFS-------PQI--NRKRK 1379

Zfish   868 AVISRDL-----VAIGD---PVGQRATKDLVLRR------ARHQQLSSDGEKRTS----RPGNKV 914
            .|.:||:     ::|.|   ..|..:|:::.|.|      .:||..|.||....|    .....:
  Fly  1380 GVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRSRSI 1444

Zfish   915 IKSASATALSVIIPGVEQHGNSPLA-------SPMSPRSLSSNPSSRDSSPSRDYCPTVTVPRSP 972
            :|||||..||:    :....||.||       ||....:.||..||||:||.|:..|.||..:.|
  Fly  1445 VKSASALGLSL----MTSLDNSQLAAQLCGIQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKPP 1505

Zfish   973 ITIQRSGKKYGFTLRAIRVYIGDTDVYSVHHIVWHVEDGGPAQEAGLCAGDLITHVNGESVHGLV 1037
            |.|:|..:.:|||:..||||.||||.|::||:|..|::|.||.||||...|||||||||:|.||.
  Fly  1506 IIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLF 1570

Zfish  1038 HTEVVELILKSGNKVTVTTTPFENTSIKVGPARRSSYKSKMAR----RSKRTVKEGQESKRRGSL 1098
            ||:|::|:|..|..||:..||.|:|||:.|..:|...:||:|:    |.|:..|...:.||:.||
  Fly  1571 HTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSL 1635

Zfish  1099 FRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHSLSGHSP-TQSYRSTPESSHLGASSQSSS 1162
            ||:|        :|:..::..:..|:..|.|.:|  |....|| ..||.|:...|...:||||:|
  Fly  1636 FRRI--------SSKRANAEMQQYSAGTSSPTTP--SARNLSPLDSSYHSSCCQSAANSSSQSTS 1690

Zfish  1163 PASSTPNSPA------------------------------TTQ---------------------- 1175
            |:||:||:|.                              .||
  Fly  1691 PSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVP 1755

Zfish  1176 ----------HMRPSSLHGLSPKLH--------------------------RQYRSARCKSAGNI 1204
                      :.|||:||||..|||                          ......|.||.|:|
  Fly  1756 VSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHI 1820

Zfish  1205 PLSPLAHTP-------SPTQSSPP---PLPGHTVGSSNTTQTFPAKLHSSPPIIRP--------- 1250
            ||||||.||       |||:|..|   ||.||..|:|||||::      ||....|
  Fly  1821 PLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY------SPGSTLPTLQTAVNAN 1879

Zfish  1251 -------RPKSAEPPRSPLLKRV--------QSAEKLGSPLSSSSEKKGGIGVMRKHSLEV---- 1296
                   |.|||| |.||||:|.        :|||...|||..|...|     ...|...|
  Fly  1880 TKKAGFARTKSAE-PSSPLLRRALSPDRLHPRSAETKISPLCCSPPIK-----QPTHQRVVTTTW 1938

Zfish  1297 ----GHSDYRKDGFHCELGLQS-----LVEIEGEN------LASAPTNSPSPTQPT--------- 1337
                |.|.....|  ..||..|     ||....|.      :|:..:.:.:.|.|:
  Fly  1939 RSTPGGSASGAGG--AVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAGTDPSATAVVTLAN 2001

Zfish  1338 --PLPPETGVLKPVRKLGRQESPLS-------RDALLAGRERERERERERERTGKANEPSRPTES 1393
              |||         |....::||.|       .:..:...|...|.|.....|....:|::...:
  Fly  2002 CEPLP---------RIAEEKDSPTSTQDSSSVSEGFMPAIEEFAEGESSSSPTQTLEKPTKVKAT 2057

Zfish  1394 KPAAVTPPGSKTSPNSETSQRHTSTIQECCLVKPQTWQPPLTKSSPIASESKSNIVTSIP-SPLT 1457
            :...:.|.|.    :.:..|..|:|             |...|:.|..|..|:::.|:.| ||..
  Fly  2058 EQPEMEPAGK----SKKVDQGKTTT-------------PGTPKTKPHNSGCKTSMTTTKPASPSV 2105

Zfish  1458 TVSSPSTKTIDQSSIREEGNDDKG 1481
            |:|:...|  |.|::...|:...|
  Fly  2106 TISTAPRK--DTSAVTGGGSSGSG 2127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mast1a	XP_009292706.1	DUF1908	61..334	CDD:286070	156/363 (43%)
		STKc_MAST	369..648	CDD:270760	209/280 (75%)
		S_TKc	370..643	CDD:214567	206/274 (75%)
		PDZ_signaling	965..1055	CDD:238492	49/89 (55%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	156/363 (43%)
		STKc_MAST	834..1115	CDD:270760	209/280 (75%)
		S_TKc	835..1110	CDD:214567	206/274 (75%)
		PDZ_signaling	1506..1587	CDD:238492	45/80 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589139
Domainoid	1	1.000	440	1.000	Domainoid score	I524
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1041	1.000	Inparanoid score	I260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm24417
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3124
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.880