Protein Alignment NLRX1 and CG8197

DIOPT Version :10

• Sequence 1: NP_078894.2
• Gene: NLRX1 / 79671
• HGNCID: 29890
• Length: 975
• Species: Homo sapiens
• Sequence 2: NP_610445.1
• Gene: CG8197 / 35912
• FlyBaseID: FBgn0033369
• Length: 387
• Species: Drosophila melanogaster
• Alignment Length: 299
• Identity: 74/299 - (24%)
• Similarity: 114/299 - (38%)
• Gaps: 75/299 - (25%)

Human   667 RQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLR---------QLNLAGVRMTPVKCTVVAAVLGS 722
            |.:||        .::.|.:..||..|....||         ||:|.|..:|.....::...|..
  Fly   102 RSLLP--------VWYIELRLMRFPREFFVMLRLNAAKMNVSQLSLEGTPLTDEDVRILREFLLV 158

Human   723 GRHALDEVNLASCQL-------------DPAGLRTLLPVFLRARKLGLQLNSLGPEACKD-LRDL 773
            .: .|..:|::||.|             ...|:|.|    ...|.||:.| ||..|.... |..|
  Fly   159 SK-TLRRLNVSSCSLTQFNFALIADGVYKSPGVRRL----SANRLLGMSL-SLDTEKISSVLSSL 217

Human   774 LLH--------DQCQITT-------------------LRLSNNPLTAAGVAVLMEGLAGNTSVTH 811
            |:.        :.|::|.                   ||::.|.:...|...|:.|::...::..
  Fly   218 LMQNTLWALSLEHCELTAQDMIPIAEHLARTNSKFRRLRIACNKIGPDGAFFLLRGMSMGGNLEL 282

Human   812 LSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELS 876
            |.|.:..:|..|.|.:|..|...|:||.|::.||..|.||...:..|.::...||.|.||.|...
  Fly   283 LDLSYCSIGTHGGEWVAKYLASCRRLQVLHLNYNDMGPTAVNLILLAMKKQCKLEKLTLYGNHFD 347

Human   877 SEGRQVLRDLGGAAEGGARVV------VSLTEGTAVSEY 909
            |....::|.|     ..|.||      :|.|...|:.:|
  Fly   348 SRTAMIVRRL-----LDAEVVLHSELDISYTYDEALQDY 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLRX1	NP_078894.2	NACHT	5..952	CDD:444362	74/299 (25%)
		Required for interaction with MAVS. /evidence=ECO:0000269|PubMed:18200010	75..556
		P-loop containing Nucleoside Triphosphate Hydrolases	160..320	CDD:476819
		Required for the repression of MAVS-induced interferon signaling. /evidence=ECO:0000269|PubMed:18200010	556..974		74/299 (25%)
		RNA1	<692..886	CDD:444072	60/243 (25%)
		leucine-rich repeat	698..726	CDD:275380	8/36 (22%)
		leucine-rich repeat	745..772	CDD:275380	9/27 (33%)
		leucine-rich repeat	773..808	CDD:275380	10/61 (16%)
		leucine-rich repeat	809..836	CDD:275380	7/26 (27%)
		leucine-rich repeat	865..886	CDD:275380	8/20 (40%)
CG8197	NP_610445.1	RNA1	<133..345	CDD:444072	54/217 (25%)
		leucine-rich repeat	202..220	CDD:275380	7/18 (39%)
		leucine-rich repeat	223..251	CDD:275380	2/27 (7%)
		leucine-rich repeat	252..279	CDD:275380	6/26 (23%)
		leucine-rich repeat	280..307	CDD:275380	7/26 (27%)
		leucine-rich repeat	308..335	CDD:275380	9/26 (35%)
		leucine-rich repeat	336..357	CDD:275380	8/20 (40%)