Protein Alignment HECTD3 and etc-1

DIOPT Version :10

• Sequence 1: NP_078878.3
• Gene: HECTD3 / 79654
• HGNCID: 26117
• Length: 861
• Species: Homo sapiens
• Sequence 2: NP_495842.1
• Gene: etc-1 / 174388
• WormBaseID: WBGene00008429
• Length: 1001
• Species: Caenorhabditis elegans
• Alignment Length: 693
• Identity: 147/693 - (21%)
• Similarity: 252/693 - (36%)
• Gaps: 233/693 - (33%)

Human   222 LIHFLYDHLGKEDENLGSVKQ-----------------------YVESIDVSSYTEEFNVSCLTD 263
            |||.::..:.:.|...|::|:                       |.:.|.:..:.|||
 Worm   463 LIHLMFPTMARGDLYSGNLKEKMYKAETDWKDVTESVFSILGAIYQKDIRLKYFPEEF------- 520

Human   264 SNADTYWESDGSQC-------QHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEGDNLK 321
                  |.:.|.:.       :...|..|..|.:  ::..|:||   .|:.:...:|  |.|
 Worm   521 ------WTNHGREVLSGIGEHRRMPRRRMPNGRL--QIERTMDT---EFVERLAAIY--EMD--- 569

Human   322 KLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDGIDVRLRGVKIKSSRQRELGLNADLFQ 386
              ||...|:         ||...:||.:
 Worm   570 --SDSENDD---------EDEDNNLPAV------------------------------------- 586

Human   387 PTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQ 451
                              .|||:.:.:.|..       :||..|          :||.|..|..|
 Worm   587 ------------------LRRAICVMKHIPF-------IVPFMD----------RVKLFTRLLNQ 616

Human   452 RPGLVAQCLRDSESSKPSFM------PRLYINRRLAMEHRACPSRDPACKNAVFTQVYEGLKPSD 510
                      |.|....|..      |.:.:.|                 :.|:...:|...|..
 Worm   617 ----------DKEKHYTSTFGMGFNGPSVTVRR-----------------DQVYMDAFETFAPKM 654

Human   511 KYEKPLDYRWPMRYD--QWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTA 573
            :.:|..|.:..:|..  .|   ..:.|..||.||.||:.|:    ||..::.:  |...||..|
 Worm   655 QGDKVNDLKSMVRVKMVNW---AGMNESGIDGGGIFREFLS----ELLKTAFN--VERGFFTFT- 709

Human   574 NQGNGTGEARDMYVPNPS--------CRDFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGE 630
                   |::.:| |||:        |  .|.:::||:::|..:..::...:....|...|:.
 Worm   710 -------ESKLLY-PNPTAPFLLGVDC--LAHFQFIGRMIGKLIYERQLQEVRFAEFFIAQIF-- 762

Human   631 EVSWSKD-----FPAVDSVLVKLLEVMEGM-DKETFEFKFGKELTFTTVLSDQQV---VELIPGG 686
            |...:||     ..:.|.::.|.|:.::.| ::|..|.    :|.|:.|.||..:   |.|.|.|
 Worm   763 ETDKNKDVDLQHMKSFDPIIFKHLKALQKMNNRELDEL----QLDFSVVTSDMGLVRNVNLKPNG 823

Human   687 AGIVVGYGDRSRFIQLVQKARLEESKEQVAAM----QAGLLKVVPQAVLDLLTWQELEKKVCGDP 747
            :...|...:...:::|.....|   |:::|:|    :.|:.:::....:.:....||:..:.|..
 Worm   824 SKFRVTVENVHEYVRLYVNYHL---KQRIASMVDAVRKGISEIISIEWMRMFAPHELQIMIAGYE 885

Human   748 EV-TVDALRKLTRFEDFEPSDSRVQY---FWEALNNFTNEDRSRFLRFVTGRSRLPARIY--IYP 806
            || |...|||..... |......:.|   ||:.::..:|:|:...|:||||.||.|...:  |.|
 Worm   886 EVFTAKELRKFCELR-FAAGTQDINYEEMFWDVIDKLSNDDKKALLKFVTGCSRAPVDGFKSIQP 949

Human   807 DKLGY----ETTDALPESSTCSSTLFLPHYASAKVCEEKLRYA 845
             ::|.    .:.|.||.|:||.:.|.:|.|::....|||||||
 Worm   950 -RMGVLVIPSSDDELPTSATCMNMLRIPKYSNRTKLEEKLRYA 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HECTD3	NP_078878.3	APC10-HECTD3	238..371	CDD:176487	26/162 (16%)
		HECT	579..845	CDD:459880	77/296 (26%)
etc-1	NP_495842.1	IQCG-IQCD	19..>47	CDD:483958
		HECTc	661..998	CDD:214523	96/362 (27%)