Protein Alignment MCPH1 and Mcph1

DIOPT Version :10

• Sequence 1: XP_016869318.1
• Gene: MCPH1 / 79648
• HGNCID: 6954
• Length: 877
• Species: Homo sapiens
• Sequence 2: XP_011240358.1
• Gene: Mcph1 / 244329
• MGIID: 2443308
• Length: 883
• Species: Mus musculus
• Alignment Length: 900
• Identity: 470/900 - (52%)
• Similarity: 579/900 - (64%)
• Gaps: 113/900 - (12%)

Human     6 LKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTWDKAQKRGVKL 70
            |||||||||||||.||||||:||..||.||||.||||.||||||||||||||||||||||.|.||
Mouse    12 LKDVVAYVEVWSSKGTENYSRTFAKQLEDMGATVSKTLNKQVTHVIFKDGYQSTWDKAQKTGAKL 76

Human    71 VSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKTPENDKRFQKKFEKMA 135
            ||||||||||.|||.:|||||||.|.:|||.:|.:||.||||||||..||||||||.||||||||
Mouse    77 VSVLWVEKCRMAGALVDESLFPAVNTDEHLPNLSRKKHKCMQPKDFILKTPENDKRLQKKFEKMA 141

Human   136 KELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSRHHSAMEKRLQEMKEKRENLSPT------- 193
            :||||||..||||||:|||||..||:|:..:.:       |::|||:|||||||||||
Mouse   142 EELQRQKAALDDDVPVLLFESPRSLVYSSPVNV-------MKRRLQDMKEKRENLSPTCKWLQCR 199

Human   194 -------------------SSQMIQQSHDNPSNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLC 239
                               :|||::||..||..||.|..||||...|.|||.||.|.||||.|
Mouse   200 MKRMSAGELQKKGYLISTLASQMLEQSQQNPCVSLFETSLNISHQPLSSDESFASGSHSSFGD-- 262

Human   240 GNSGCGNQERKLEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEINLQR 304
               .||:|||||..|.|::.:..|.||.||:|::.:.|.|..||.:..|||...:.|||.||.|:
Mouse   263 ---SCGDQERKLGRSANEMTTVTCPSSPVLRASSFYGSASPNHLRQPRPQKAPDSPSKESINCQK 324

Human   305 NIAGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKE 369
            :..|.|...::|||||:||...:||..||||:|..:.| .:...|::||.||||.: ...|.||.
Mouse   325 DATGAVADSERKQAAGVSQGVPDEKLCLSPTMSIIEEH-QVRLGPKNSSAKRKRAA-DLGSSPKG 387

Human   370 KCKRKRSTRRSIMPRLQLCRSE----DRLQHVAG-PALEALSCGESSYDDYFSPDNLKERYSENL 429
            |.| ||..|:|.: .:||.:|:    ..::.:.| |.:||     |||:|||||||||||.||.|
Mouse   388 KLK-KRYKRKSAL-AIQLFKSDQSPPSTIRLIPGTPDVEA-----SSYEDYFSPDNLKERNSERL 445

Human   430 PPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTV-DITNFTAKTISSPRKTGNGEGR 493
            |||:|..:||:...||.|||.||.::.||.||:|:|:|.|:: .|::..:|:.||..|....|..
Mouse   446 PPEAQQLASPSLFHCRGLSKWERRNMLEMCDFTCIGEKHRSISSISDLISKSASSLEKPVKEEVN 510

Human   494 ATSSC---VTSAPEEALRCCRQAG---KEDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEM 552
            ..|:|   |.::..::...|.|.|   ::|..|||:....|:...|      ..:|||:|:..|.
Mouse   511 TASTCLLLVETSANDSPGLCSQPGPQLRDDTGPEGSSHPDTLSSSA------HHITPLKGNSTET 569

Human   553 KEAVGLKSTQNKGTTSKISNSSEGEAQSEHEPCFI---VDCNMETSTEEKENLPGGYSGSVKNRP 614
            ::....|.:..:|:|...|.|.|.|...    |.:   .|||:|.|.|||||:..|||.||||.|
Mouse   570 RDPGDGKGSPKEGSTPPASASPEDEVHI----CNLSLGEDCNVEKSVEEKENIATGYSESVKNGP 630

Human   615 TRHDVLDDSCDGFKDLIKPHEELKKSGRGKK---------------------------------- 645
            .|.|..|.||.|   |::|.::.|||.:.:|
Mouse   631 GRPDPSDSSCTG---LVRPQQKPKKSEKEEKAGGFASVRSGVSPQGSVLQYITGVDSQFKSCSFL 692

Human   646 -PTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLS 709
             |||||||||||||||.::||||..|||||.||:|||||||||.||..||||||:|||||||:||
Mouse   693 QPTRTLVMTSMPSEKQTLIIQVVSTLKGFSFAPEVCETTTHVLVGKSARTLNVLMGIARGCWILS 757

Human   710 YDWVLWSLELGHWISEEPFELSHHFPAAPLCRSECHLSAGPYRGTLFADQPAMFVSPASSPPVAK 774
            |:|||.||||||||||||||||..|||||:||.|.|||...|:|||||:||.||::||||||.||
Mouse   758 YEWVLLSLELGHWISEEPFELSETFPAAPICRLERHLSTQQYQGTLFANQPKMFIAPASSPPRAK 822

Human   775 LCELVHLCGGRVSQVPRQASIVIGPYSGKKKATVKYLSEKWVLDGVSLCHQAGVC 829
            |||||.||||:||..|:.||::||||.|||||.::|||||||||.::   |..:|
Mouse   823 LCELVLLCGGQVSPAPQLASLIIGPYKGKKKARIQYLSEKWVLDSIT---QHKIC 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	XP_016869318.1	BRCT_microcephalin_rpt1	8..86	CDD:349348	67/77 (87%)
		Microcephalin	225..607	CDD:463511	157/396 (40%)
		BRCT_microcephalin_rpt2	648..723	CDD:349368	60/74 (81%)
		BRCT_microcephalin_rpt3	749..824	CDD:349382	50/74 (68%)
Mcph1	XP_011240358.1	BRCT_microcephalin_rpt1	14..92	CDD:349348	67/77 (87%)
		Microcephalin	250..623	CDD:463511	157/396 (40%)
		BRCT_microcephalin_rpt2	696..771	CDD:349368	60/74 (81%)
		BRCT_microcephalin_rpt3	797..873	CDD:349382	51/78 (65%)