Protein Alignment MCPH1 and mcph1

DIOPT Version :10

• Sequence 1: XP_016869318.1
• Gene: MCPH1 / 79648
• HGNCID: 6954
• Length: 877
• Species: Homo sapiens
• Sequence 2: XP_017949218.2
• Gene: mcph1 / 100038095
• XenbaseID: XB-GENE-487210
• Length: 820
• Species: Xenopus tropicalis
• Alignment Length: 880
• Identity: 354/880 - (40%)
• Similarity: 479/880 - (54%)
• Gaps: 151/880 - (17%)

Human     5 ILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTWDKAQKRGVK 69
            :|.||.|||||||||..|||||||:.|||::||||||||||.:|||:||||:|.|||||.|.|||
 Frog    15 VLSDVTAYVEVWSSNRRENYSKTFSQQLVNLGAKVSKTFNKHITHVVFKDGHQGTWDKAVKAGVK 79

Human    70 LVSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKTPENDKRFQKKFEKM 134
            ||||||||:||.|.||:|||.|||.|.|:.|..::|||.||||||||..||||||:|.|:||:||
 Frog    80 LVSVLWVERCREAAAHVDESEFPAINTNDGLPQIVKKKHKCMQPKDFVEKTPENDRRMQRKFDKM 144

Human   135 AKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSRHHSAMEKRLQEMKEKRENLSPTSSQMIQ 199
            :|||:.||..:||  |:|||:..|:|:|:|. .:.:...:|||||::|||.||||||||:|| |.
 Frog   145 SKELKVQKAGVDD--PVLLFDQYGTLMYSPK-AVAADRCNAMEKRIKEMKNKRENLSPTASQ-IS 205

Human   200 QSHDNPS---------NSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCGNSGCGNQERKLEGSI 255
            |:.|.|.         ::|..:||    |..|.|      |.:|:|:|     .|:.|:|...|
 Frog   206 QTFDFPQLKPSLGYSPSALGSSPL----DNGCDD------LDTSYDEL-----WGSLEKKRNIS- 254

Human   256 NDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEI--NLQRNIAGKVVTPDQKQA 318
            |..|:.|.....|::|..:..........|||     :||:.::|  .|:||  ...||..||::
 Frog   255 NYSKNKVTSKKSVIRATELEDPNCLLTSGKSS-----NNLTPQQIKDKLRRN--SHAVTSFQKKS 312

Human   319 --AGMSQETFEE---KYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSHGSHSPPKEKCKRKRST- 377
              :....:|.||   .:....|.|:...::...:.|...:|.::          .|..|:.||.
 Frog   313 RKSLARSKTVEEPVQSFMNCGTQSALNSNVDYEALPNKLTVCKE----------NESTKKVRSNC 367

Human   378 RRSIMPRLQLCRSEDRLQHVAGPALEALSCGE------SSYDDYFSPDNLKE------RYS-ENL 429
            |:|..|...|..|.:.:.....|.|..|..|.      ||::|:||.| ||.      |:| ..|
 Frog   368 RKSKTPTSNLHLSTENIVMPEIPKLSELRNGSDSEGACSSFEDFFSAD-LKSQKRPFARFSLGTL 431

Human   430 PPESQLPSSPAQL-SCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNFTAKTISSPRKTGNGEGR 493
            ||||  |:||..: :.:..|:|.|.|:.::.:.:|.||:.|         |:|.|.....|.|.:
 Frog   432 PPES--PTSPLFIKNKKGSSRKRRRSVQDLEECNCSGKRRR---------KSICSKDNLVNSEFK 485

Human   494 ATSSCVTSAPEEALRCCRQAGKEDACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMKEAVGL 558
            ..:..::...:              |.|.|.....|...|
 Frog   486 HDAKTMSPVAD--------------CVERNPIKTKINKTA------------------------- 511

Human   559 KSTQ--NKGTTSKISNSSEGEAQSEHEPCFIVDCN----------METST--------------- 596
            ||.|  ||||||....|||....:........:.|          ||..|
 Frog   512 KSDQVNNKGTTSSSLLSSETNLNTNDTLATSTELNQKKDIGLVKGMEKITELTTCKKSPNQPVMK 576

Human   597 -----EEKENLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMP 656
                 |::|:.|..:....|::....|.|....:..::....:|||||..:.:|.:.:.|||||.
 Frog   577 NGAESEKQEDEPKSFQKYAKSKYPACDSLSKILNEQRNKCNDNEELKKKEKTRKISGSFVMTSMC 641

Human   657 SEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELGH 721
            ||:||.|||||....||..:..||||||||::|.|.||||::||||||||::||||||||||.||
 Frog   642 SERQNTVIQVVKTFGGFVFSDHVCETTTHVIAGSPRRTLNIILGIARGCWIISYDWVLWSLECGH 706

Human   722 WISEEPFELSHHFPAAPLCRSECHLSAGPYRGTLFADQPAMFVSPASSPPVAKLCELVHLCGGRV 786
            ||||||:|||.||||||:||.:.|||||.|:..|.:..||:|:||.|.||..||.|:|.||||:|
 Frog   707 WISEEPYELSDHFPAAPICRLQRHLSAGEYQQDLLSSLPAVFISPGSQPPCDKLSEVVQLCGGKV 771

Human   787 SQVPRQASIVIGPYSGKKKATVKYLSEKWVLDGVS 821
            .:..|||.:.||.::||:...|.|:||||:||.|:
 Frog   772 CKAIRQAKVCIGEFNGKRAPDVLYVSEKWLLDSVT 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCPH1	XP_016869318.1	BRCT_microcephalin_rpt1	8..86	CDD:349348	60/77 (78%)
		Microcephalin	225..607	CDD:463511	101/435 (23%)
		BRCT_microcephalin_rpt2	648..723	CDD:349368	50/74 (68%)
		BRCT_microcephalin_rpt3	749..824	CDD:349382	36/73 (49%)
mcph1	XP_017949218.2	BRCT_microcephalin_rpt1	18..96	CDD:349348	60/77 (78%)
		BRCT_microcephalin_rpt2	634..708	CDD:349368	50/73 (68%)
		BRCT_microcephalin_rpt3	734..810	CDD:349382	36/73 (49%)