DRSC/TRiP Functional Genomics Resources

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Protein Alignment FAT4 and Cad89D

DIOPT Version :10

Sequence 1:NP_001278232.1 Gene:FAT4 / 79633 HGNCID:23109 Length:4983 Species:Homo sapiens
Sequence 2:NP_650554.3 Gene:Cad89D / 42006 FlyBaseID:FBgn0038439 Length:2240 Species:Drosophila melanogaster


Alignment Length:2074 Identity:494/2074 - (23%)
Similarity:778/2074 - (37%) Gaps:596/2074 - (28%)


- Green bases have known domain annotations that are detailed below.


Human  1003 VTLSESEPVNSRFFKVQ------ASDKDSGANGEIAY-TIAEGN-TGDAFGIFPDGQLYIKSELD 1059
            :.|.|...|.....::|      |:.|.:.|:|:..| .:.|.| |.....:....:..:..::.
  Fly    76 IRLREDAQVGKEILRLQAYPRSTAALKGADASGDHKYFNLTEHNATTLVVSLARSLERLVDRDVP 140

Human  1060 RELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK-VS 1123
            |.|....:|.....::..|  .:.:::||.:||||||.|.|.:..|....:|.....|.:.: |.
  Fly   141 RNLLKFRILCAGKQEKLEE--GSYLSITVYIEDVNDNAPEFLNVPYVVDVDENTSIESIIFEGVQ 203

Human  1124 AVDKD--FGPNGEVRYSFEMV--------QPDFELHAISGEITNTHQFDRESLMRRR------GT 1172
            |.|:|  ..||.||.:|...|        .|.|.|       .:.|   |..|:.:|      |.
  Fly   204 AFDRDKPNTPNSEVHFSMSTVPEQLSADGSPYFAL-------KSPH---RPLLILKRELDFDNGI 258

Human  1173 AVFSFTVIATDQGIPQPLKDQA--TVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLR---- 1231
            ..|...:.|.|:|.|   .:||  |:.:.::|::|..|||.:..|:..|:|........:|    
  Fly   259 RQFKLPIFAWDRGTP---ANQANTTITINVRDVDDLPPKFTEGVYRTRINEFYPMTGVPIRIPLY 320

Human  1232 ----VSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDY--EATPAYSLVIQ---- 1286
                :.|.|.|..|..|: |.||.|||.:.|.::..:|.:.|..::|.  |:.|..:.|:|    
  Fly   321 FAPPIMAFDQDSLNASLV-YDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFVLQLEAR 384

Human  1287 AVDSGTIPL-NSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADL 1350
            ..|:   || .:...:.:::||.|||.|.|......:.::||:..|..|..|.|.|.|.|:|::.
  Fly   385 QKDN---PLKKALARIEVEVLDLNDNVPEFEADYYNISIVENLPTGFSVLQVNAVDRDQGENSEF 446

Human  1351 YYSITGTNN-HGTFSISPNTGSIFLA--KKLDFETQSLYKLNITAKDQG---------RPPRSST 1403
            .|::..|.: .|.|.|...||.|.:.  :.||.|.:...:||:.|.::.         :.|..|.
  Fly   447 LYNLVETKDAAGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSK 511

Human  1404 MSVVIHVRDFNDNPPSFPPGDIFK-SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGN 1467
            :.|.|.:.|.|||.|.|..|:::: .:..|.|.|..:..|.|||||...||.|.|.:  |.|:|:
  Fly   512 VQVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGPNGHLLYEL--QRPKGS 574

Human  1468 ---HFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILV-TDLND---- 1524
               .|.:|...||||....:.|....:|   |:|.||......||::|..:||.| ..::|    
  Fly   575 GYIPFRLDNKNGTIYVGGPLRRGRIAVF---VEATDQPTNPSERRFSLAVITIEVYATIDDQAID 636

Human  1525 ------------NVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTD--TF 1575
                        |.|:..|           :|.|.||::.    ||.: ||.|::::..::  .|
  Fly   637 FVGAPYEFWVGANTPLGTS-----------VGQVRTTLIY----EGGD-EIMYDLLHTYSEGVPF 685

Human  1576 IVDRYSGDLRVASALVP-SQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITILK 1639
            .::..||.:.|...|.. .:.:|.....|..|.....:|     :::.....|:.|......:..
  Fly   686 AIEERSGIITVIRELSEFKRKVYQFEAVANYLFANSSQS-----LVMSRSSSPLTTIASPAELSD 745

Human  1640 EGEPIGTNVISIEAASPRGSEAP-------VEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILD 1697
            ||..| || ::|...:....:.|       :...::....||..||         |||       
  Fly   746 EGVLI-TN-LTIHIVNKPEQKVPLRPVIEEINMNVIHFHVEENVVG---------GII------- 792

Human  1698 REQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQL 1762
               |..||...:..:.......|...:|               ||       ..||..||:....
  Fly   793 ---GQLLYKNGINLVNNELGTYREMPSE---------------PT-------SRNITMGSRFRSR 832

Human  1763 TAMDADEG-----------ANALVTYTIISGADDSFRID-PESGDLIATRRLDRERRSKYSL--L 1813
            ....:.:.           ||..:.|.|.:..:...:|. .|.|.|:....||||::..|.|  :
  Fly   833 NRSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVI 897

Human  1814 VRADDGLQSSD--MRINITVSDVNDHTPKFSRPVYSFDIPEDTIPG---SLVAAILATDDDSGVN 1873
            |....||.|..  .::||.|.||||:.|||:...|...|.|:.:.|   |:..|||..|.|.|.|
  Fly   898 VEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNALTYVGLINENCVVGTELSMNHAILIQDADEGPN 962

Human  1874 GEITYIVNED--DEDGIFFLN-------------PITGVFNLTRLLDYEVQQYYILTVRAEDGGG 1923
            .|....:..|  ||..|.::|             ..||.||:                       
  Fly   963 AEFRVQLQGDYSDEFSIEYVNGTSSENSTHHKMPSTTGAFNI----------------------- 1004

Human  1924 QFTTIRVYFNILDV-NDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGD 1987
                    ||:.|. ||.   |......|:.|                       |..:.::||.
  Fly  1005 --------FNLTDQWNDE---FKYQELHTTFM-----------------------QTNFKLSSGP 1035

Human  1988 SLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF- 2051
               .|.:...|    .:.||||.|..|||.:...|     ....:..|.:::::.|||||.|.| 
  Fly  1036 ---YFRISYTG----KRGLDREKQQLYNLKIIAAD-----TGGLSGYAHLTVLVADVNDNAPMFE 1088

Human  2052 ----LSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGEL 2112
                .......|.|.| .|..::..:::...:.|.:.....|..|..:      |.|..|.  .:
  Fly  1089 RISVFKDSRLEIREYT-TDMEIYFVESSSGMTAPQATAAMMLAPPPYH------IPGSPRF--NV 1144

Human  2113 DREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVF 2177
            |||......|.|||..|.:..         ||..:....|:||       |.|:|..||.::|:.
  Fly  1145 DRERSVGAGLGVVARAKSRRR---------MVRALTTKCPLFA-------IYEDTPVGTKVLQLS 1193

Human  2178 AADGDEGTNGQVRYGIVNGNTNQE-------------FRIDSVTGAITVAKPLDREKTPTYHLTV 2229
            |:|.|.|.|..:.|.:......:.             |.||.::|.::|..||........:|||
  Fly  1194 ASDEDFGKNALLHYELQGEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTV 1258

Human  2230 QATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTIL-QVVARDDDRGSNS 2293
            ...|    ...|::.:...::|:|:..|.|:.|.||.:.||  |....::| |:.|.|.|.|.|:
  Fly  1259 TDID----GLKDSTCLRFTVMDVNNHAPTFKKSWYSFDTPE--GEYKDSVLGQLTAIDMDFGENA 1317

Human  2294 KLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVN 2358
            .::|                                     |.:||..|                
  Fly  1318 NITY-------------------------------------TLSDSHLP---------------- 1329

Human  2359 DNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNSQFTINPSTGQIITSA 2423
                                                               |||.|::|.:....
  Fly  1330 ---------------------------------------------------FTIKPASGVLKIGG 1343

Human  2424 LLDRETKDNYTLVVVCSD-AGSPEPLSSSTSVLVTVTDVNDNPPRFQHHP--------------- 2472
            .||||.||.|:..|:.:| |...:.:|||..|.|.|.|:|||.|.|..:.               
  Fly  1344 QLDRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADR 1408

Human  2473 ------YVTHIPSPTLPGSFVFAVTVTDAD-IG-PNSELHYSLSGRNSEK----FHIDPLRGAIM 2525
                  |..::...|.||:||..:|..|.| :| .|..:.||:  |:.|.    |.||...|.|.
  Fly  1409 TLMLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSI--RHQEMQAPLFQIDSRDGTIS 1471

Human  2526 AAGPLNGASE---VTFSVHVKDGGSFPKTDSTTVTVRFVN-----KADFPKVRAKEQTFMFPENQ 2582
            ....:||.::   :..||...|.|| |...:|.:.:  ||     ..|.||...|.:.   |.|.
  Fly  1472 TISRINGYNDYEHLNVSVIASDVGS-PALSATAIVI--VNLQGQAVTDPPKSTPKPEP---PANV 1530

Human  2583 PVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGG 2647
            .|..              .:||.......|...|:.:  ::::|..|:.|. .::.:|:|  :| 
  Fly  1531 TVFQ--------------HAYYEVKLTENNEAPIEVM--RLNLSAGLNPEN-YRWSLWLE--EG- 1575

Human  2648 FPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNG 2712
                          ||..|..|.|:.|           .:.:|                      
  Fly  1576 --------------LDETDAHPPFEYD-----------AKNML---------------------- 1593

Human  2713 NMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQS------------------TSV 2759
                          :.:::|.|||.:|.|.|.|::......:::                  ...
  Fly  1594 --------------LYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIEGLSLNEC 1644

Human  2760 KVMINILDENDNAPRF---SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMD--ASLP 2819
            :::::|.|||||||:|   .|...|.:|:::..||.||||..:|.|.|:||..||.:::  |.| 
  Fly  1645 RILVHIADENDNAPKFRGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPARL- 1708

Human  2820 FTINPSTGDIVISRPLNRED---------TDRYRIRVSAHDSGWTVSTDVTIFVTDIND 2869
            |.|:..:|:|.:...|:|.:         ||    |:.|.|..   |..|.:||..||:
  Fly  1709 FGIDELSGNIRLLGELSRTEHIYGFDVKATD----RMGADDGR---SGIVNVFVYIINE 1760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAT4NP_001278232.1 Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 899..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637 22/100 (22%)
Cadherin_repeat 1105..1206 CDD:206637 30/119 (25%)
Cadherin_repeat 1215..1311 CDD:206637 29/110 (26%)
Cadherin_repeat 1321..1416 CDD:206637 30/106 (28%)
Cadherin_repeat 1428..1525 CDD:206637 35/116 (30%)
Cadherin_repeat 1540..1622 CDD:206637 18/84 (21%)
Cadherin_repeat 1634..1736 CDD:206637 19/108 (18%)
Cadherin_repeat 1747..1837 CDD:206637 28/105 (27%)
Cadherin_repeat 1845..1940 CDD:206637 26/113 (23%)
Cadherin_repeat 1948..2047 CDD:206637 20/98 (20%)
Cadherin_repeat 2057..2150 CDD:206637 20/92 (22%)
Cadherin_repeat 2159..2254 CDD:206637 25/107 (23%)
Cadherin_repeat 2263..2360 CDD:206637 17/97 (18%)
Cadherin_repeat 2369..2464 CDD:206637 23/95 (24%)
Cadherin_repeat 2472..2559 CDD:206637 29/116 (25%)
Cadherin_repeat 2573..2667 CDD:206637 15/93 (16%)
Cadherin_repeat 2675..2771 CDD:206637 13/113 (12%)
Cadherin_repeat 2778..2870 CDD:206637 34/103 (33%)
Cadherin_repeat 2878..2981 CDD:206637
Cadherin_repeat 2990..3085 CDD:206637
Cadherin_repeat 3095..3192 CDD:206637
Cadherin_repeat 3201..3295 CDD:206637
Cadherin_repeat 3305..3402 CDD:206637
Cadherin_repeat 3410..3508 CDD:206637
Cadherin_repeat 3516..3612 CDD:206637
EGF_CA 3864..3900 CDD:238011
EGF_CA 3902..3938 CDD:238011
EGF_CA 3941..3976 CDD:238011
LamG 3979..4142 CDD:238058
EGF 4168..4198 CDD:394967
LamG 4247..4368 CDD:238058
EGF_CA 4431..4465 CDD:238011
Cad89DNP_650554.3 Cadherin_repeat 183..290 CDD:206637 30/119 (25%)
Cadherin_repeat 325..407 CDD:206637 25/85 (29%)
Cadherin_repeat 416..524 CDD:206637 30/107 (28%)
Cadherin_repeat 534..626 CDD:206637 33/96 (34%)
Cadherin_repeat 641..>714 CDD:206637 18/88 (20%)
CA 851..925 CDD:214520 25/73 (34%)
CA 1026..1085 CDD:214520 20/70 (29%)
Cadherin_repeat 1177..1280 CDD:206637 28/113 (25%)
Cadherin_repeat 1289..1385 CDD:206637 40/201 (20%)
Cadherin_repeat 1414..1510 CDD:206637 31/100 (31%)
CA 1576..1658 CDD:214520 21/128 (16%)
Cadherin_repeat 1666..1760 CDD:206637 33/101 (33%)
Blue background indicates that the domain is not in the aligned region.

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