Protein Alignment FAT4 and dpy

DIOPT Version :10

• Sequence 1: NP_001278232.1
• Gene: FAT4 / 79633
• HGNCID: 23109
• Length: 4983
• Species: Homo sapiens
• Sequence 2: NP_001260032.1
• Gene: dpy / 318824
• FlyBaseID: FBgn0053196
• Length: 22949
• Species: Drosophila melanogaster
• Alignment Length: 5819
• Identity: 1055/5819 - (18%)
• Similarity: 1686/5819 - (28%)
• Gaps: 2070/5819 - (35%)

Human    35 PGQAWVHGAEPRQVFQVLEEQPPGTLVG--TIQTRPGFTYRLSESHALFAINSSTGALYTTSTID 97
            |..|.:....|....:.....|.|:..|  |.||                 .||...:.||..::
  Fly  4905 PSSASLETTVPSVTLETTTNVPIGSTGGQVTEQT-----------------TSSPSEVRTTIRVE 4952

Human    98 RESLPSDVINLVVLSSAPTYPT-------------EVRVLVRDLNDNAPV---FPDPSIVVTFKE 146
            ..:|||...:....|.:|..||             :.....||:....|.   .|.|:.:.|
  Fly  4953 ESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSEQTTESTRDVPTTRPFEASTPSPASLET--- 5014

Human   147 DSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDRE 211
               :...|.|:|.|:..|||.|              |:.....|.:||
  Fly  5015 ---TVPSVTLETTTNVPIGSTG--------------GQVTEQTTSSPS----------------- 5045

Human   212 VTPQYQLLVEVEDKGEPKR-----------------------RGYL-QVNVTVQDINDNPPVFGS 252
               :.:..:.||:...|.|                       |.|. |...:.:|:....|
  Fly  5046 ---EVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRTYSDQTTESTRDVPTTRP---- 5103

Human   253 SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEAR- 316
              ::|..|..|.:.::|..|.   ::..||..|      ..|..|:   ||. |...|.:|...
  Fly  5104 --FEASTPSPASLETTVPSVT---SETTTNVPI------GSTGGQV---TGQ-TTAPPSEFRTTI 5153

Human   317 --RQYSLTVQAMDRGVPSLTGRAEALIQ---LLDVNDNDPVVKFRYFPATSRY-ASVDENAQVGT 375
              .:.:|..::.||..||.:......:.   ....:.:......|..|.|..: ||....|.:.|
  Fly  5154 RVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLET 5218

Human   376 V---VALLTVTDADSPAANGNISVQILGG-NEQR-HFEVQSSKVPNLSLIKVASALDRE------ 429
            .   |.|.|.|:....:..|.::.|.... :|.| ...|:.|.:|:.|..:...:...|
  Fly  5219 TVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPS 5283

Human   430 ----RIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPP 490
                |..|...|.|..|.....|..|  :..|.|||...|      |.|.|:....|      |.
  Fly  5284 DFTTRPHSEQTTESTRDVPATRPFEA--STPSPASLETTV------PSVTSEATTNV------PI 5334

Human   491 GSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISAR 555
            ||  :|...|:..:...:.:|.:|         .:.|     :|..|...||...|:.....:..
  Fly  5335 GS--TGGQVTEQTTSSPSEVRTTI---------RVEE-----STLPSRSTDRTSPSESPETPTTL 5383

Human   556 DQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRF 620
            ......:....|......||...:| |........|:....|:.|.........|..|...|.:.
  Fly  5384 PSDFTTRPHSDQTTECTRDVPTTRP-FEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQT 5447

Human   621 SLQEAETDRRSFRLDPVSGRLSTI--SSLDREEQA-FYSLLVLATDLGSPPQSSMARINVSLLDI 682
            :...:|. |.:.|::.     ||:  .|.||...: ......|.:|..:.|.|.  :...|..|:
  Fly  5448 TSSPSEV-RTTIRVEE-----STLPSRSADRTTPSESPETPTLPSDFTTRPHSE--QTTESTRDV 5504

Human   683 NDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNG--TVKYSISAGDRSRFQVNAQSGVI 745
            ....|........|.::...|.   :|..:.|:..:|:.|  ..:.:.|:....|..:..:...:
  Fly  5505 PTTRPFEASTPSSASLETTVPS---VTLETTTNVPIGSTGGQVTEQTTSSPSEFRTTIRVEESTL 5566

Human   746 STRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGY 810
            .:|.| ||                  .:|:::..|.|:.......|
  Fly  5567 PSRSA-DR------------------TTPSESPETPTLPSDFTTRP------------------- 5593

Human   811 HVGSVSASTMDLNSNISYLITTGDQKGM-FAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVT 874
            |....:.||.|:.:...:..:|.....: ..:..||.: ||.||           .:.::||.||
  Fly  5594 HSEQTTESTRDVPTTRPFEASTPSPASLETTVPSVTSE-TTTNV-----------PIGSTGGQVT 5646

Human   875 GDTM-----VNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ 934
            |.|.     |..|::                  ||     .|...:::.|             :.
  Fly  5647 GQTTAPPSEVRTTIR------------------VE-----ESTLPSRSTD-------------RT 5675

Human   935 NPKNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQL---------SSSVILTV--YVHD 988
            .|      :|...|.::| |.|....:|..:...|...||..         .:|:..||  ...:
  Fly  5676 TP------SESPETPTIL-PSDSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLE 5733

Human   989 VNDNSPVFD---QLSYEVTLSESE-----PVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFG 1045
            ...|.|:..   |::.:.|.:.||     .|.......:::|:.|.:......|....:    |.
  Fly  5734 TTTNVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTSPSESPETPTTLPSD----FT 5794

Human  1046 IFPDGQLYIKSELDRELQDRYVLMVVASDRAVE---PLSATVNVTV--ILEDVNDNRPLFNSTNY 1105
            ..|......:|..|           |.:.|..|   |..|::..||  :..:...|.|:
  Fly  5795 TRPHSDQTTESTRD-----------VPTTRPFEASTPSPASLETTVPSVTSETTTNVPI------ 5842

Human  1106 TFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRR 1170
                      ||..|:|:  ::......|||.:..:.:....          :...||.|.....
  Fly  5843 ----------GSTGGQVT--EQTTSSPSEVRTTIGLEESTLP----------SRSTDRTSPSESP 5885

Human  1171 GTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSAS 1235
            .|.    |.:.:| .|.:|..||.|...  :|:....|      ::|:....|:..|.|..|::.
  Fly  5886 ETP----TTLPSD-FITRPHSDQTTEST--RDVPTTRP------FEASTPSPASLETTVPSVTSE 5937

Human  1236 DVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNST-- 1298
            ..                  ....|.||.||||  |:.  .|.|:.......|:..|:|..||
  Fly  5938 TT------------------TNVPIGSTGGQVT--GQT--TAPPSEVRTTIGVEESTLPSRSTDR 5980

Human  1299 ----------CTLNIDIL------DENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDN 1347
                      .||..|.:      ...::|...|.:..|  .........|.::|.:..|::..|
  Fly  5981 TSPSESPETPTTLPSDFITRPHSEQTTESTRDVPTTRPF--EASTPSPASLKTTVPSVTSEATTN 6043

Human  1348 ADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412
            ..:  ..||.....|.|.||             ||.:....:.|.:........||..|.. .|.
  Fly  6044 VPI--GSTGQRIGTTPSESP-------------ETPTTLPSDFTTRPHSEKTTESTRDVPT-TRP 6092

Human  1413 FNDNPPSFPPGDIFKSI-------VENIPIGTS---VISVTAHDPDADINGQLSYTIIQQMPRGN 1467
            |..:.||  |..:..::       ..|:|||::   |...|...|
  Fly  6093 FETSTPS--PASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSP-------------------- 6135

Human  1468 HFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIE------------TRRYALKNVTILVT 1520
                .||:.||.....         .|..::.|:..|.|            ||.::.:     .|
  Fly  6136 ----SEVRTTIRVEES---------TLPSRSADRTTPSESPETPTLPSDFTTRPHSEQ-----TT 6182

Human  1521 DLNDNVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLR 1585
            :...:||......|....|:    |:.||:.:...:...|..|      |.|        .|.:.
  Fly  6183 ESTRDVPTTRPFEASTPSPA----SLETTVPSVTSETTTNVPI------GST--------GGQVT 6229

Human  1586 VASALVPSQLIYNLIVSATDLGPER---RKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTN 1647
            ..:...||::...:.|..:.| |.|   |.|.:|.......|.....|:|......:....:.|
  Fly  6230 GQTTAPPSEVRTTIGVEESTL-PSRSTDRTSPSESPETPTTLPSDFITRPHSEQTTESTRDVPT- 6292

Human  1648 VISIEAASPRGSEAPVEYYIVSVRCEEKT---VGRLFTIGRHTGIIQTAAILDREQGACLYLVDV 1709
            ....||::|  |.|.::..:.||..|..|   :|.  |.|:.|
  Fly  6293 TRPFEASTP--SPASLKTTVPSVTSEATTNVPIGS--TGGQVT---------------------- 6331

Human  1710 YAIEKSTAFPRTQRAEVEI-------------TLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQ 1761
               |::|:.|...|..:.:             |..:..:.|...|:|.......|...:.::.:.
  Fly  6332 ---EQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSEKTTESTRDVP 6393

Human  1762 LT-----------AMDADEGANALVTYTII----SGADDSFRIDPESGDLIATRRLDRERRSKYS 1811
            .|           :::....:..|.|.|.:    :|...:.:......::..|.|::..     :
  Fly  6394 TTRPFETSTPSPASLETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTTIRVEES-----T 6453

Human  1812 LLVRADDGLQSSDMRINITV--SD--VNDHTPKFSRPVYSFDIP-----EDTIPGSLVAAILATD 1867
            |..|:.|....|:.....|.  ||  ...|:.|.:..  :.|:|     |.:.|.|.
  Fly  6454 LPSRSTDRTSPSESPETPTTLPSDFITRPHSEKTTES--TRDVPTTRPFEASTPSSA-------- 6508

Human  1868 DDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLT--RLLDYEVQQYYILTVRAEDGGGQFTT--- 1927
             .||.|..|:|..|.         ...:..||.:  |....|..:...|.       ..|||
  Fly  6509 -SSGNNCSISYFRNH---------YKCSNRFNRSADRTTPSESPETPTLP-------SDFTTRPH 6556

Human  1928 -IRVYFNILDVNDNPPIFSLNSYSTSLME------------NLPVGSTVLVFNVTDADDGINSQL 1979
             .:...:..||....| |..::.|.:.:|            |:|:|||
  Fly  6557 SEQTTESTRDVPTTRP-FEASTPSPASLETTVPSVTSETTTNVPIGST----------------- 6603

Human  1980 TYSIASGDSLGQFTVDKNGVLKVL---------KALDRESQSFYNLVVQVHDLPQIPASRFTSTA 2035
                 .|...||.|...:.|...:         ::.||.:.|      :..:.|.|..|.||:..
  Fly  6604 -----GGQVTGQTTAPPSEVRTTIRVEESTLPSRSTDRTTPS------ESPETPTILPSDFTTRP 6657

Human  2036 QVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIG 2100
            ..........|.|.|  .|.....|....::|.|           |:..:|.|...|:|:  :.|
  Fly  6658 HSDQTTESTRDVPTT--RPFEASTPRPVTLETAV-----------PSVTLETTTNVPIGS--TGG 6707

Human  2101 TIDGEVRLTGELDRE--EVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEI 2163
            .:.|:...|....|.  .|...||...:||:..||.|..|...:.    :|    |....:..:.
  Fly  6708 QVTGQTTATPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLP----SD----FTTRPHSDQT 6764

Human  2164 NENTLTGTDI--IQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAI---TVAKPLD----- 2218
            .|:|   .|:  .:.|.|......:.:.....|...|.....|.|..|.:   |.:.|.:
  Fly  6765 TEST---RDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTI 6826

Human  2219 --REKTPTYHLTVQATDRGS---TPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT 2278
              .|.|    |..::|||.|   :|.|.|:..|       ||:    ..|:|....|:...:|.|
  Fly  6827 GLEEST----LPSRSTDRTSPSESPETPTTLPS-------DFI----TRPHSDQTTESTRDVPTT 6876

Human  2279 ILQVVARDDDRGSNSKLSY--------------VLFG--GNEDNAFTLSASGELGVTQSLDRETK 2327
                  |..:..:.|..|.              |..|  |.:....|.|:..|:..|..|:..|
  Fly  6877 ------RPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTEQTTSSPSEVRTTIGLEEST- 6934

Human  2328 ERFVLMITATDSGSPA---LTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLL---V 2386
                |...:||..||:   .|.|...:..:...:.:..|.:::...||.|.:|.|.:...|   |
  Fly  6935 ----LPSRSTDRTSPSESPETPTTLPSDFITRPHSDQTTESTRDVPTTRPFEASTPSSASLETTV 6995

Human  2387 NASDADASKNAVISYRIIGG--NSQFTINPS----TGQIITSALLDRET------KDNYTLVVVC 2439
            .:...:.:.|..|.  ..||  ..|.|.:||    |.::..|.|..|.|      :...|...:.
  Fly  6996 PSVTLETTTNVPIG--STGGQVTEQTTSSPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLP 7058

Human  2440 SD------------------------AGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTH---- 2476
            ||                        |.:|.|::..|:||...::...|.|.......||.
  Fly  7059 SDFTTRPHSDQTTESSRDVPTTQPFEASTPRPVTLQTAVLPVTSETTTNVPIGSTGGQVTEQTTS 7123

Human  2477 ---------------IPS---------------PTLPGSF------------------------- 2486
                           :||               .|||..|
  Fly  7124 SPSEVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESS 7188

Human  2487 -------------VFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTF 2538
                         |.:.|.|:..||       |..|:.:|:....|              |||..
  Fly  7189 TPRPVTLETAVPPVTSETTTNVPIG-------STGGQVTEQTTPSP--------------SEVRT 7232

Human  2539 SVHVKDGGSFPK---------------------------TDSTTVTVRFVNKADFPKVRAKEQTF 2576
            ::.::: .:||.                           :|.||.:.|     |.|..|..|.:.
  Fly  7233 TIRIEE-STFPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTR-----DVPTTRPFESST 7291

Human  2577 MFPEN-----QPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQK 2636
            ..|..     .||:|..||             .:|.|:.|.     |:|.|.: |.|.:..
  Fly  7292 PRPVTLEIAVPPVTSETTT-------------NVAIGSTGG-----QVTEQTT-SSPSEVR---- 7333

Human  2637 YVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPI-----FKEDPFISEILENLSPRKILTVSAMD 2696
              ..|...:...|..|:    |.|....:...|.     |...|...:..|  |.|.:.|....:
  Fly  7334 --TTIRVEESTLPSRST----DRTTPSESPETPTTLPSDFTTRPHSDQTTE--STRDVPTTRPFE 7390

Human  2697 KDSGPNGQLDYEIVNGNMENSFSI------NHATG-------EIRSVRPLDREKVSHYVLTIKSS 2748
            ..:.....|:..:.:..:|.:.|:      ...||       |:|:.     .:|....|..:|:
  Fly  7391 ASTPSPASLETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTT-----IRVEESTLPSRST 7450

Human  2749 DKGSPSQSTSVKVMI-----------NILDENDNAPRFSQIFSAHVPE----------------- 2785
            |:..||:|......:           ...:.:.:.|. :|.|.:..|.
  Fly  7451 DRTPPSESPETPTTLPSDFTTRPHSDQTTESSRDVPT-TQPFESSTPRPVTLEIAVPPVTSETTT 7514

Human  2786 NSPLGYTVTRVTTSDEDIGINAISRYSIMDASLP----------------------FTINP---- 2824
            |.|:|.|..:||...........:...:.:::||                      ||..|
  Fly  7515 NVPIGSTGGQVTGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQ 7579

Human  2825 ---STGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPEL 2886
               ||.|:..:||..           ::..|..::.|.|.....:...|.|
  Fly  7580 TTESTRDVPTTRPFE-----------ASTPSPASLETTVPSVTLETTTNVP-------------- 7619

Human  2887 TEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRH 2951
              |||...||         .||.             .||..|:             .:.:.:...
  Fly  7620 --IGSTGGQV---------TGQT-------------TATPSEV-------------RTTIGVEES 7647

Human  2952 SFIVTSSDRGKPSLISETTVTI-NIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDF 3015
            :....|:||..||...||..|: :...:..::.|..:|....|.|:..:..|.  |...::....
  Fly  7648 TLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTP--RPVTLETAVP 7710

Human  3016 GLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVT----AKDKGNPPLSSQAT 3076
            .:.||.                  |..:.:.|::.|:...|..|..|    |.....||...:.|
  Fly  7711 SVTSET------------------TTNVPIGSTVTSETTTNVPIGSTGGQVAGQTTAPPSEVRTT 7757

Human  3077 VHI------------TVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV-------SARDRDAAM 3122
            :.:            |...|:..||....|..: |.|.|.......|.|       ::....|::
  Fly  7758 IRVEESTLPSRSADRTTPSESPETPTTLPSDFT-TRPHSEQTTESTRDVPTTRPFEASTPSPASL 7821

Human  3123 NGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI 3187
            ...:. |::|.....: .|.|:.|.||            .:.|.|..:    .||     |:.|.
  Fly  7822 ETTVP-SVTSETTTNV-PIGSTGGQLT------------EQSTSSPSE----VRT-----TIRVE 7863

Human  3188 DVNDNSPVFLSDDYFPTVLENAPSG-----TTVIHLNAT-------------DADSGTNAVIAYT 3234
            :  ...|...:|..||:.....|:.     ||..||..|             :..:.:...:..|
  Fly  7864 E--STLPSRSTDRTFPSESPEKPTTLPSDFTTRPHLEQTTESTRDVLTTRPFETSTPSPVSLETT 7926

Human  3235 VQSSDSDLFVIDPNTGVITTQGFLDFETK------------QSYHLTVK----------AFNVPD 3277
            |.|..|:   ...|..:.:|.|.:..:|.            :|.|..|.          |..||.
  Fly  7927 VPSVTSE---TSTNVPIGSTGGQVTEQTTAPPSVRTTETIVKSTHPAVSPDTTIPSEIPATRVPL 7988

Human  3278 EERCSFATVNIQLKG-----TNEYVPRFVSKLYYFEISEAA-PKGTIVGEVFASDRDLGTDGEVH 3336
            |......|......|     |:...|...::|...|.:|.. |..|:      |.|| ..:..|.
  Fly  7989 ESTTRLYTDQTIPPGSTDRTTSSERPDESTRLTSEESTETTRPVPTV------SPRD-ALETTVT 8046

Human  3337 YLIFGNSR------KKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNV 3395
            .||...::      .:| |:.::|.: .||.:......:.|:.:.:..|..|           ..
  Fly  8047 SLITETTKTTSGGTPRG-QVTERTTK-SVSELTTGRSSDVVTERTMPSNISS-----------TT 8098

Human  3396 TVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQ 3460
            ||.:.::|           :|:.:|....:|...:..:..:|: .:..|          ..::.|
  Fly  8099 TVFNNSEP-----------VSDNLPTTISITVTDSPTTVPVPT-CKTDY----------DCLDEQ 8141

Human  3461 T---GQITVTAELDRETLPIYNLSVLAV-------------DSGTPSATGSASLLVTLED----- 3504
            |   ||.....|.......:.||::...             |...|..:..|.:.....|
  Fly  8142 TCIGGQCISPCEYFTNLCTVQNLTICRTLNHTTKCYCDTDDDVNRPDCSMKAEIGCASSDECPSQ 8206

Human  3505 ---IN----------------------DNGPMLTVSEGEV--MENKRPG---------------- 3526
               ||                      ::.|:.:...|..  .|:..||
  Fly  8207 QACINALCVDPCTFNNPCSRNEDCRVFNHQPLCSAEHGRTPGCEHCPPGANCDPTTGACIKANVT 8271

Human  3527 -TLVMTLQSTDPDLP--------PNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADF 3582
             |.:.|..||...:|        ||.|      :.|.|.|:  .::|....:||
  Fly  8272 ITTITTKNSTSTKIPTKPRTTANPNTG------VKTTPTTT--RVTTRNTTTTT----------- 8317

Human  3583 YLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLD 3647
               ..|..|.....|||.|.......:|..|....|..
  Fly  8318 ---TTTTTSSTSTESSTITSATNQTSKNQKPDTESTTS--------------------------- 8352

Human  3648 SFHCSLT----SGVTSLFSIPGGTCDLNSQPRSTDGTFDLTVLSNDGV------HSTVTSNIRVF 3702
              |...|    .|..::...|        .||.|..|   |.|..:||      .||.|..::..
  Fly  8353 --HTDATRRYRDGENNITDTP--------TPRPTIQT---TTLRGEGVMGDSQRRSTTTPKMKTT 8404

Human  3703 FAGFSNATVDNSILLRLGVPTVKDFLTNHYLHFLRIASSQLTGLGTAVQLYSAYEENNRTFLLAA 3767
            ....||...|.:....:.:||.:                     ||..::|:       |.....
  Fly  8405 RLDTSNEVPDTTSPWPIELPTTE---------------------GTTTEVYN-------TMFAPV 8441

Human  3768 VKRNHNQYVNPSGVAT---------------------------------FFES------------ 3787
            |.......:||..|.|                                 ..||
  Fly  8442 VNTTDTSLINPCTVDTNCAPNEHCKLGHCRKKEPPGSPKTPEPCQSNNDCIESEACYMGLCQDPC 8506

Human  3788 --------------------------------IKEILLRQSGVKVESVDHDSC------------ 3808
                                            :|.:..:.|   :|..|...|
  Fly  8507 EFAKICAATAKCTAKSHRPVCTCPQGHEGNPMVKCVTTQTS---IECTDDSDCGVTEACINQLCQ 8568

Human  3809 ----VHGPCQNGGSCLR---------------------RLAVSSVLKSRESLPVIIVAN------ 3842
                ||.||.....|:.                     :.|.|.|.:..|..|...:.:
  Fly  8569 HPCDVHDPCATNAVCINSNHAADCSCADGFQGNGFVGCQPARSHVCQYNEDCPPTKLCDRLNRRC 8633

Human  3843 -EPLQP---------------FLCKCLPGYAGSWCEIDIDECLP-------SPCHSGGTCHN--- 3881
             .|.|.               ..|:||||:.|:    ...:|||       |.|.|...|.|
  Fly  8634 INPCQEDSCGENAECIPVNHGTECRCLPGFLGN----AYVQCLPSQGCRSDSECDSSQACINGKC 8694

Human  3882 ----LVGGFS----------CSCPDGFTGR---ACERDINECLQSPCKNGAICQNFPGSFNCVCK 3929
                ..|.::          |.||.|:.|.   .|....:.|..:||...|:|:...|:..|.|.
  Fly  8695 SSPCQCGAYALCDVVNHRGVCKCPPGYNGNPKVGCSPPQDPCDPNPCGLNALCELDNGNPICYCP 8759

Human  3930 TGYTG---KMCESSVNYCECNPCFNGGSCQSGVDSYYCHC-----------------------PF 3968
            .|.||   |.|....:.|..|||.....|:....:..|.|                       |.
  Fly  8760 KGLTGNPFKNCIPEGDECTPNPCGPNSGCRRVGGNPVCFCLPEYEGQPPSIPCELPSNPCDPSPC 8824

Human  3969 GVFGKHCELNSYGFEEL----SYMEFPS-----LDPNN----NYIYVKFATIKSHALLLYNYDNQ 4020
            |. ...|.:.|.||.:.    :|:|.|:     ::|.|    |..........|...:.|..||:
  Fly  8825 GP-NTQCSVLSNGFSKCTCLPNYVESPNTIRGCVEPINPCDPNPCGTGAICDSSRHPVCYCPDNK 8888

Human  4021 TGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHFHTVIARRAGMAASLTVDSC----- 4080
            .|:                       .::|.....|                   |::.|
  Fly  8889 IGN-----------------------PFRLCDKPAV-------------------TIELCQPGPC 8911

Human  4081 --------SENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHD-FVGCI 4136
                    :.|:|..||  .:..|.|.:....:|:|.    :....|.......|.:.| ...|:
  Fly  8912 GRNAECYVAGNREECYC--RSGYVGDAYQGCREPSRT----VCDPNPCGPNANCVVAGDGQTACV 8970

Human  4137 MEFAVNGRPLE----------------PSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSW 4185
            ....::|.|..                .|:|.......|.||   |||.:     |..|......
  Fly  8971 CPDGLSGDPTSVIGCHGYECQVDADCPNSKACMGYRCYDPCP---GACGQ-----GAHCQVEEHH 9027

Human  4186 QQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEV 4250
            ..|.|..||||                ..|...|.:...:|..         .:..|.|.|| |.
  Fly  9028 PVCSCNSGLTG----------------NPGIRCYALDHPKKNP---------CVPSPCGRNS-EC 9066

Human  4251 KFRTR-------------SENGVLIHIQESSNY-TTVKIKNGKVYFTSDAGIAG-----KVERNI 4296
            |....             .::|.......:|:. .|:...|.|........|.|     .|.::.
  Fly  9067 KLLNNRAVCSCIPGYLGDPQSGCQPECDINSDCGDTLSCINHKCVDPCAGAICGINAICNVRQHT 9131

Human  4297 PEVYVADGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTISLGGIPPNQAHRDAQT 4361
            |.....||                                |.|...|.....||..|.:.
  Fly  9132 PVCLCLDG--------------------------------FVGDAFLQCVPIGILKNVSR----- 9159

Human  4362 AGFDGCIASMWYGGESLPFSGKHSLAS-----ISKTDPSVKIGCRGPNI---------CASN-PC 4411
               |.|..|.         .|.|.:.|     ::..||     |.|||.         |..| .|
  Fly  9160 ---DPCAPSP---------CGPHDVCSVYGDGVALCDP-----CFGPNAQQNPRCRPECVGNSDC 9207

Human  4412 WGDLLCINQWYAYRCVP--PGDCASH------------PCQNG--------------------GS 4442
            ..|..|:.|    ||:.  ||.|..:            .|..|                    .|
  Fly  9208 PFDRACLGQ----RCLDPCPGSCGRNAICNVYEHNPVCACPTGLFGNPYEQCTTKSVVETPPQPS 9268

Human  4443 CEPGLHSGFTCSCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPAGHV-----CVLSQG--PEEI 4500
            |.. ||.|....|...|:|..|         :|.:|..   |.|  |:     |||:..  .|:.
  Fly  9269 CAK-LHCGANAECKRQHSGLAC---------VCRKGYF---GDP--HIGCRPECVLNSDCPAEKA 9318

Human  4501 SLPLWAVPAIVGSCATVLALLVLS---LILCNQCRGKKAK--------NPKEEKKPKEKKKKGSE 4554
            .|....|.|..|.|.......|::   :.:|.:.....|.        .|.|...|.|..
  Fly  9319 CLNSKCVEACTGVCGVNAVCRVVNHAPVCICAEGYSGDASIACNPFYLPPPERPHPCEPS----- 9378

Human  4555 NVAFDDPDNIPPYGDDMTVRKQPEGNPKPDIIERENPYLIYDETDIPHNSETIPSAPLASPEQEI 4619
                       |.|.:...:..|:|               |.......|.:..|  |:..||..:
  Fly  9379 -----------PCGPNSRCKATPDG---------------YAACSCLPNFKGAP--PVCQPECVV 9415

Human  4620 EHYDIDNASSIAPSDADIIQHYKQFRSHTPKFSIQRHSPLGFARQSPMPLGASSLTYQPSYGQGL 4684
                   :|..||:.|.:.|..                      ..|.| |..        |.|.
  Fly  9416 -------SSECAPNQACLNQRC----------------------TDPCP-GIC--------GGGA 9442

Human  4685 RTSSLSHSACPTPNPL----SRHSPAPFSKSSTFYRNSPARELHLPIRD-GNTLEMHGDTCQPGI 4744
            |...|:|      ||:    :.....||...|             ||:| |..:.:..:.|.|..
  Fly  9443 RCEVLNH------NPICSCEANFEGDPFVACS-------------PIQDPGRDIPVPKNPCVPSP 9488

Human  4745 F--NYATRLGRRSKSPQAMASH-GSRPGSRLKQPIGQIPLESSPPVGLSIE---EVERLNTPRPR 4803
            .  |...::.:.......:|:: ||.|..|             |...||.|   :...:| .:.:
  Fly  9489 CGPNSICQIKQNRPVCSCVANYIGSPPYCR-------------PECTLSSECPSDKACIN-EKCQ 9539

Human  4804 NP--SICS--------ADHGRSSSEED--------CRRPLSRTRNPADGI------PAPESSSDS 4844
            ||  ::|.        |.....|.:||        |.:.:  |..|.|.|      |..|::..:
  Fly  9540 NPCANVCGHNARCTVIAHSAHCSCDEDYEGDAFIGCSKKI--TERPGDHIDPCYPNPCAENAVCT 9602

Human  4845 DSHESFTCSEME-YDRE------KP-MVYTSRMP 4870
            ..:.:..|:.:| |:.:      :| .:|:|..|
  Fly  9603 PYNNAARCTCIEPYNGDPYSTGCRPECIYSSECP 9636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FAT4	NP_001278232.1	Cadherin_repeat	48..131	CDD:206637	19/97 (20%)
		Cadherin_repeat	139..246	CDD:206637	21/130 (16%)
		Cadherin_repeat	254..349	CDD:206637	20/100 (20%)
		Cadherin_repeat	364..471	CDD:206637	29/122 (24%)
		Cadherin_repeat	479..577	CDD:206637	17/97 (18%)
		Cadherin_repeat	588..685	CDD:206637	20/99 (20%)
		Cadherin_repeat	693..789	CDD:206637	15/97 (15%)
		Cadherin_repeat	798..889	CDD:206637	19/96 (20%)
		Cadherin_repeat	899..992	CDD:206637	17/103 (17%)
		Cadherin_repeat	1000..1096	CDD:206637	18/105 (17%)
		Cadherin_repeat	1105..1206	CDD:206637	19/100 (19%)
		Cadherin_repeat	1215..1311	CDD:206637	23/113 (20%)
		Cadherin_repeat	1321..1416	CDD:206637	19/94 (20%)
		Cadherin_repeat	1428..1525	CDD:206637	18/118 (15%)
		Cadherin_repeat	1540..1622	CDD:206637	17/84 (20%)
		Cadherin_repeat	1634..1736	CDD:206637	19/117 (16%)
		Cadherin_repeat	1747..1837	CDD:206637	15/108 (14%)
		Cadherin_repeat	1845..1940	CDD:206637	21/105 (20%)
		Cadherin_repeat	1948..2047	CDD:206637	20/119 (17%)
		Cadherin_repeat	2057..2150	CDD:206637	21/94 (22%)
		Cadherin_repeat	2159..2254	CDD:206637	23/109 (21%)
		Cadherin_repeat	2263..2360	CDD:206637	24/115 (21%)
		Cadherin_repeat	2369..2464	CDD:206637	29/133 (22%)
		Cadherin_repeat	2472..2559	CDD:206637	25/185 (14%)
		Cadherin_repeat	2573..2667	CDD:206637	20/98 (20%)
		Cadherin_repeat	2675..2771	CDD:206637	19/119 (16%)
		Cadherin_repeat	2778..2870	CDD:206637	21/137 (15%)
		Cadherin_repeat	2878..2981	CDD:206637	18/103 (17%)
		Cadherin_repeat	2990..3085	CDD:206637	17/110 (15%)
		Cadherin_repeat	3095..3192	CDD:206637	19/103 (18%)
		Cadherin_repeat	3201..3295	CDD:206637	26/138 (19%)
		Cadherin_repeat	3305..3402	CDD:206637	20/103 (19%)
		Cadherin_repeat	3410..3508	CDD:206637	18/143 (13%)
		Cadherin_repeat	3516..3612	CDD:206637	25/122 (20%)
		EGF_CA	3864..3900	CDD:238011	14/62 (23%)
		EGF_CA	3902..3938	CDD:238011	12/38 (32%)
		EGF_CA	3941..3976	CDD:238011	9/57 (16%)
		LamG	3979..4142	CDD:238058	30/189 (16%)
		EGF	4168..4198	CDD:394967	9/29 (31%)
		LamG	4247..4368	CDD:238058	21/139 (15%)
		EGF_CA	4431..4465	CDD:238011	11/65 (17%)
dpy	NP_001260032.1	EGF_3	137..166	CDD:463759
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:463759
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		Herpes_BLLF1	<4032..4489	CDD:282904
		Herpes_BLLF1	<4334..4797	CDD:282904
		PHA03255	4845..>5021	CDD:165513	27/138 (20%)
		DUF5585	4959..5356	CDD:465521	93/471 (20%)
		PHA03247	<5170..5799	CDD:223021	141/767 (18%)
		PRK12495	<5749..5877	CDD:183558	27/170 (16%)
		PHA03247	<5865..6485	CDD:223021	140/776 (18%)
		Chi1	6385..>6609	CDD:442692	47/278 (17%)
		Herpes_BLLF1	<6607..7102	CDD:282904	118/554 (21%)
		Herpes_BLLF1	<7027..7490	CDD:282904	87/526 (17%)
		DUF5585	7550..7954	CDD:465521	91/514 (18%)
		DUF5585	7881..>8130	CDD:465521	50/282 (18%)
		Atrophin-1	18652..>19081	CDD:460830
		PHA03247	<18873..19514	CDD:223021
		ZP	22576..22811	CDD:214579