DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FAT4 and fat4

DIOPT Version :9

Sequence 1:	NP_001278232.1	Gene:	FAT4 / 79633	HGNCID:	23109	Length:	4983	Species:	Homo sapiens
Sequence 2:	XP_004911174.2	Gene:	fat4 / 100145590	XenbaseID:	XB-GENE-981052	Length:	4962	Species:	Xenopus tropicalis

Alignment Length:	4973	Identity:	3805/4973 - (76%)
Similarity:	4377/4973 - (88%)	Gaps:	34/4973 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    21 VSQL-LRVFWLLSLLPGQAWVHGAEPRQVFQVLEEQPPGTLVGTIQTRPGFTYRLSESHALFAIN 84
            |:|: |.|..||..:||.  :..::|||||||||||||||.||||.|:|||||||||.|.||:||
Frog    14 VTQMCLLVSLLLLQVPGV--LCSSQPRQVFQVLEEQPPGTYVGTISTKPGFTYRLSEFHVLFSIN 76

Human    85 SSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSS 149
            |:||::||||.||||||.|||||||||||.||||||||:.|.|:|||:||||:|||||:||||:.
Frog    77 STTGSIYTTSNIDRESLISDVINLVVLSSQPTYPTEVRITVLDINDNSPVFPEPSIVVSFKEDTQ 141

Human   150 SGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTP 214
            .|||||||||||||.|:||||||||||:.||:.|||:|.||:|||||||||||:|:|.||||..|
Frog   142 GGRQVILDTATDSDAGTNGVDHRSYRIVSGNQDGRFKLGITVNPSGEGAFLHLMSQGPLDRETNP 206

Human   215 QYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADE 279
            .|.|||||||||.|||.|:|||||||||||||||||.||.|||.:.||:.||||||:|.|.|.||
Frog   207 CYYLLVEVEDKGTPKRLGHLQVNVTVQDINDNPPVFSSSQYQAKIEEDSPVGSSVLKVEATDRDE 271

Human   280 GTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLL 344
            |.||.|||:|. ||||||:|||:||:|:|||||:|:||||:|::||.|.|.|.||||:|||::|:
Frog   272 GPNAAIRYQLA-EGTPFQIDPESGLVTIREPLDYESRRQYTLSIQAKDLGTPPLTGRSEALVRLI 335

Human   345 DVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEV 409
            |||||||||||||||||||||||||||||||||||||||||||||||||::|.||||||||||||
Frog   336 DVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNVTVAILGGNEQRHFEV 400

Human   410 QSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPV 474
            |:|||||||||||||:|||||||||||||||||. |.|     :.|||||||||:||||||||||
Frog   401 QTSKVPNLSLIKVASSLDRERIPSYNLTVSVSDQ-GHP-----RPRSSVASLVIYVNDINDHPPV 459

Human   475 FSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGG 539
            |.:...:|.:||:.|||||:.|:||:|||:||||||||||||||.||||.|||:|||||  |:..
Frog   460 FQEPHSKVEISEDLPPGSYICGVSASDGDTGLNANLRYSIVSGNKLGWFSISENSGLVT--STSA 522

Human   540 LDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFS--QPEGYDVSVVENAPTGTEL 602
            ||||:|.|::|||||||||..||.|||.|:|.||||||:||.|:  ...|:.||:.||:..||||
Frog   523 LDREIAPQLLLNISARDQGPQPKTSYATLLVNLLDVNDQKPTFTGINVNGHLVSLPENSLVGTEL 587

Human   603 LMLRATDGDLGDNGTVRFSLQEAETDRRS-----FRLDPVSGRLSTISSLDREEQAFYSLLVLAT 662
            |||:|||||||||||:||..   :.|..|     |||||:||:||..:.||||:|...:|.:|||
Frog   588 LMLKATDGDLGDNGTIRFYF---DADNPSQCQGLFRLDPLSGKLSNRADLDREQQDRCTLQILAT 649

Human   663 DLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYS 727
            |||:||.||.|::.|||||:||||||||||||||:|:||||..|::.||:|:|||||.|||::||
Frog   650 DLGTPPLSSTAKVIVSLLDVNDNSPVFYPVQYFANIQENEPPASFVATVTASDPDLGINGTIRYS 714

Human   728 ISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPV 792
            |.|||.|:|||:.::|.|||:.|||||||||||||:||||||.|||.|.|||||||||||||||.
Frog   715 IRAGDTSKFQVHPETGAISTKAALDREEKTAYQLQVVATDGGGLQSHNHAIVTITVLDTQDNPPS 779

Human   793 FSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDRE 857
            |||.:||||:|||||:||:||:|.|:|:|||:||:||:|||||||:|.|::.||.:.||:|:|||
Frog   780 FSQGSYSFVMFENVAVGYNVGTVVATTIDLNTNITYLVTTGDQKGVFTIDRSTGLIMTASVVDRE 844

Human   858 EQSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDE 922
            ||.|||||||||||.|||:.:|||||||||||||||:.|:|:|||||||:.||.|||||||||||
Frog   845 EQDFYQLKVVASGGAVTGEAIVNITVKDLNDNSPHFVNAVENVNVVENWKTGHIIFQAKAVDPDE 909

Human   923 GVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVH 987
            ||||.|.|||||||::||.::|..|.:||.|||||..||||:||:|||||||||:||.|||:.||
Frog   910 GVNGRVSYSLKQNPQSLFYVDEVTGAVSLTGPLDVDTGSYQVEIIASDMGVPQLASSFILTISVH 974

Human   988 DVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQL 1052
            |||||.||||||||||||.||||||||||||.|:|||||.||||.|:|..||.|:||||||||||
Frog   975 DVNDNPPVFDQLSYEVTLLESEPVNSRFFKVYATDKDSGLNGEITYSIIHGNVGEAFGIFPDGQL 1039

Human  1053 YIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGS 1117
            |:|||||||::|.|:|.|.||||||||||.|||||:|||||||||||||||||.||||||...||
Frog  1040 YVKSELDREVKDLYILQVSASDRAVEPLSTTVNVTIILEDVNDNRPLFNSTNYVFYFEEENSGGS 1104

Human  1118 FVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIAT 1182
            |||::.|||||.|.|||:.|:||.:||||||:.::||||:|||||||:|||:||.|.|:..|.:|
Frog  1105 FVGRIYAVDKDSGSNGEIMYAFETMQPDFELNTVTGEITSTHQFDREALMRQRGAAAFTLKVTST 1169

Human  1183 DQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHY 1247
            |.|:|:||||||||.:|::|||||.|||.||.|||:|||.|:|:|||||||:|||||||||||.|
Frog  1170 DLGLPKPLKDQATVQIYIRDINDNHPKFSKDLYQASISELASNMTQVLRVSSSDVDEGNNGLISY 1234

Human  1248 SIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNT 1312
            ||:|||||:.|.:||::|||.|:|:||||||.:|||:|||||||.:||::|.||:|::||||||:
Frog  1235 SIMKGNEEKHFTMDSSTGQVALVGRLDYEATASYSLIIQAVDSGAVPLSATSTLSIEVLDENDNS 1299

Human  1313 PSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKK 1377
            |||||:.|||||:||||:|||||||||||||||||||::||||||||||||||||||||||||||
Frog  1300 PSFPKAALFVDVVENMRVGELVSSVTATDSDSGDNADIHYSITGTNNHGTFSISPNTGSIFLAKK 1364

Human  1378 LDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISV 1442
            ||||||:||||||||||:|.|||||||||:|.||||||||||||.||||||:|||:.||||:::|
Frog  1365 LDFETQALYKLNITAKDKGNPPRSSTMSVIIKVRDFNDNPPSFPAGDIFKSVVENVLIGTSILTV 1429

Human  1443 TAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIET 1507
            ||.||||||||||:||||||.||||||.||||:|||||||||||||||||||||:|:|.|||:|:
Frog  1430 TATDPDADINGQLTYTIIQQKPRGNHFVIDEVRGTIYTNAEIDREFANLFELTVRASDLAVPLES 1494

Human  1508 RRYALKNVTILVTDLNDNVPMFISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDT 1572
            |:|||||||||::|||||||.|:||||.|||||..|||||:||.|.|||||:|||||||||:|||
Frog  1495 RKYALKNVTILISDLNDNVPTFVSQNAFAADPSLAIGSVLSTITAFDPDEGSNGEIEYEIISGDT 1559

Human  1573 DTFIVDRYSGDLRVASALVPSQLIYNLIVSATDLGPERRKSTTELTIILQGLDGPVFTQPKYITI 1637
            :||||||||||||||:.::||.|||:|||:|||||.||:.:||||||||:|.|||||:|.|||||
Frog  1560 ETFIVDRYSGDLRVAAPMLPSHLIYSLIVAATDLGAERKATTTELTIILEGQDGPVFSQLKYITI 1624

Human  1638 LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGA 1702
            ||||||:|||||:||||||||:::.|||:|||||||.:||||||||||:||:|||||:||||:||
Frog  1625 LKEGEPVGTNVINIEAASPRGTDSVVEYFIVSVRCEGRTVGRLFTIGRNTGVIQTAAVLDRERGA 1689

Human  1703 CLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDA 1767
            .|||||||||||..:.|:||||:||||||||||||||||||:||||||||:|||||||||||.||
Frog  1690 RLYLVDVYAIEKEASLPKTQRAQVEITLQDINDNPPVFPTDILDLTVEENVGDGSKIMQLTATDA 1754

Human  1768 DEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVS 1832
            |||.||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||:|
Frog  1755 DEGPNALVTYTIISGADDSFRIDPESGDLIATKRLDRERRSKYSLLVRADDGLQSSDMRINITIS 1819

Human  1833 DVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGV 1897
            |||||.|||||.|||||:.|||||||:|||||||||||||||||||.|::||:||||||||:|||
Frog  1820 DVNDHIPKFSRAVYSFDVAEDTIPGSIVAAILATDDDSGVNGEITYAVSDDDDDGIFFLNPVTGV 1884

Human  1898 FNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGST 1962
            ||:||.||||:||||:|||.|:|||||.:.:||||||||||||||:||.||||.|:|||||.|||
Frog  1885 FNVTRALDYELQQYYVLTVCAQDGGGQDSCVRVYFNILDVNDNPPVFSRNSYSASVMENLPPGST 1949

Human  1963 VLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIP 2027
            :|.|||||||||.||:|:|:|:||||:|||.|.|:|.|.||:.||||:||||:|||||||:...|
Frog  1950 ILTFNVTDADDGFNSKLSYTISSGDSMGQFQVSKDGTLSVLQLLDRETQSFYSLVVQVHDMAPPP 2014

Human  2028 ASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNP 2092
            |.|:||:.:|||||||||||||:|:||||||:.||||.|||||:||||||||||||||:|:||..
Frog  2015 APRYTSSVEVSIILLDVNDNPPSFISPKLTYVQENTPTDTVVFRAQATDPDSGPNSYIQYSLLGS 2079

Human  2093 LGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQA 2157
            ||||||||.||||||||||||||::||||||::|.|||:||||||.::.::|||||||:|.|:|.
Frog  2080 LGNKFSIGIIDGEVRLTGELDREDISNYTLTIIAKDKGEPSLSSSMDMNIIVLDINDNSPHFSQR 2144

Human  2158 LYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKT 2222
            .:||||:|:||||||:||:.|:|.|||.||.|||.|::||.:.|||||||||.:::|:|||||:.
Frog  2145 HFKVEISESTLTGTDLIQLIASDADEGINGMVRYAIIDGNPSNEFRIDSVTGVLSIARPLDRERK 2209

Human  2223 PTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDD 2287
            .:|.|.:||:||||:||:||:||||:|.||||.||.||||||:|:|||||.|||:.|||||||||
Frog  2210 SSYTLKIQASDRGSSPRSDTATVSILLSDINDVVPKFELSPYTVSVPENLETLPKIILQVVARDD 2274

Human  2288 DRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINV 2352
            |:|.||:|:|.|..||||.|||||:||:|.:.:|||||.||.:.|:|||||:|.|||||||||::
Frog  2275 DQGLNSRLTYSLASGNEDGAFTLSSSGQLSLIKSLDREVKEWYSLLITATDAGFPALTGTGTISI 2339

Human  2353 IVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVISYRIIGGNSQFTINPSTG 2417
            .|:|:|||.||||...:|.|||||||||||:|:||.||:||.:|.||.|.:.|||||||||||||
Frog  2340 QVEDINDNKPTFALNHHFITIPEDAPTGTDILMVNCSDSDAGQNGVIRYSLNGGNSQFTINPSTG 2404

Human  2418 QIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTL 2482
            |||:|:|||||.||:|||:|:.:|.||| ||:|:|:|.|.:.|||||||||.||||||||||||.
Frog  2405 QIISSSLLDREAKDHYTLLVIATDGGSP-PLTSTTNVTVNIRDVNDNPPRFLHHPYVTHIPSPTT 2468

Human  2483 PGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGS 2547
            .|||||||||||.|||.|:|||:||.||||||||||||||||..||.:.||||:||||||:|||.
Frog  2469 AGSFVFAVTVTDEDIGSNAELHFSLKGRNSEKFHIDPLRGAIRTAGAIEGASEITFSVHVRDGGL 2533

Human  2548 FPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGN 2612
            ..|||.|||||||.||||||.:||..:||.|||||.|.:||:||.|||.||..:|:||||||.||
Frog  2534 NSKTDLTTVTVRFANKADFPLIRADRKTFTFPENQEVGTLVSTIFGSSSRGGSLSFYIASGNFGN 2598

Human  2613 TFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFI 2677
            ||.||:|.||:.|..|||||.:.||.:|:||||.|||||||||||:|||||||||.|.||:||||
Frog  2599 TFHIDELNGQLYIKNPLDFETMPKYELWVEARDMGFPPFSSYEKLEITVLDVNDNQPQFKQDPFI 2663

Human  2678 SEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYV 2742
            :||:||||||||||:||.|||||.|||::|.|.:||.|..||||...||||:.|.|||||.|.|.
Frog  2664 AEIIENLSPRKILTISAEDKDSGSNGQVEYTIFDGNKEAFFSINRVNGEIRNTRQLDREKASQYT 2728

Human  2743 LTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGINA 2807
            |::|:||||||::|:.|||:|.:||:|||||||||||||.|.||:.||..||:|||||||.|.||
Frog  2729 LSVKASDKGSPARSSIVKVIIYVLDDNDNAPRFSQIFSAFVAENAVLGCFVTQVTTSDEDAGANA 2793

Human  2808 ISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAP 2872
            ||||:|.|.||||.||.:||.|.:||||||||.|||.:|||||||||||||||||||||:|||||
Frog  2794 ISRYTIADTSLPFHINLNTGVITVSRPLNREDNDRYIVRVSAHDSGWTVSTDVTIFVTDVNDNAP 2858

Human  2873 RFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKY 2937
            |||:.|||||.||..:||||||||||||.|||.||.|:||||||||.||||:|||||||||.|||
Frog  2859 RFSKPSYYLDYPETLDIGSKVTQVFATDSDEGLNGHVYYFIKSQSELFRINSTTGEIFNKQHLKY 2923

Human  2938 QNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGT 3002
            ||.:...|:|||||||||::||||.|.::|||||:|||||||||||:|..:||||||:||.|:||
Frog  2924 QNPSVSGNININRHSFIVSASDRGSPPIMSETTVSINIVDSNDNAPKFSSTKYFTPVSKNAKIGT 2988

Human  3003 KLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKG 3067
            |||:|||:|||||||||||.|.:|.:|..|||::|.:||||:|||||:.|:|:|:.|.|.|||||
Frog  2989 KLIKVTAVDDKDFGLNSEVGYSLSTENIHGKFQIDKETGWITVASSLMMDINKNYMIKVFAKDKG 3053

Human  3068 NPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISS 3132
            ||||||||.|:|||||||||||||||||:|.|:.||.|:|:::||:|||||||:|||:|.|:|||
Frog  3054 NPPLSSQALVNITVTEENYHTPEFSQSHVSVTVLESLSVGTVIRTISARDRDASMNGIIAYNISS 3118

Human  3133 GNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFL 3197
            |||.|:||||:|||.|:|.|.|||||||||::||||:||||||:||||.||:.|.|||||.|:|.
Frog  3119 GNEAGLFAINASTGALSLLKNLDYELCQKHDLTISAVDGGWVAKTGYCVVTIYVKDVNDNPPIFK 3183

Human  3198 SDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFET 3262
            :|:|||:|:||||||||||.|||||.||..||||||:||||||||||||||||:||||||||:||
Frog  3184 ADEYFPSVMENAPSGTTVIRLNATDVDSAPNAVIAYSVQSSDSDLFVIDPNTGIITTQGFLDYET 3248

Human  3263 KQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDR 3327
            ||.||||||||||||||||||.||.:||:|.|||||||||||||||:||||||||:|||||||||
Frog  3249 KQHYHLTVKAFNVPDEERCSFVTVTVQLEGANEYVPRFVSKLYYFEVSEAAPKGTVVGEVFASDR 3313

Human  3328 DLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVT 3392
            |.|.||:|||||||:|||||||||||||:|.||||||||||||:|||::|||.|||||||||||.
Frog  3314 DGGIDGDVHYLIFGSSRKKGFQINKKTGKISVSGILDREKEERISLKIIAKNVGSIRGADIDEVN 3378

Human  3393 VNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSI 3457
            ||:|:|||||||:|:|.:|:|||||||..||||||||||||||:||||||||||||||:.|||:|
Frog  3379 VNITILDANDPPVFSLKVYNVQISEGVTPGTHVTFVSAFDSDSVPSWSRFSYFIGSGNDKGAFAI 3443

Human  3458 NPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVMEN 3522
            ||||||:|||.|||||..|:|||:|||:|||:|||||||:|||||:|||||||.|:.::|||.||
Frog  3444 NPQTGQVTVTTELDREMTPLYNLTVLAIDSGSPSATGSAALLVTLDDINDNGPTLSTTKGEVKEN 3508

Human  3523 KRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYLSVV 3587
            .|.||.||||||||.|||||||||:||||||||||||||||..|:|:||||||||||.:|:||||
Frog  3509 YRAGTHVMTLQSTDLDLPPNQGPFSYYLLSTGPATSYFSLSPGGILTTTREIDREQINEFFLSVV 3573

Human  3588 TKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCS 3652
            |:|||.|||||||||||||.|||||||:.|.|:|||:|||||||||.||||||||||||||||||
Frog  3574 TRDSGFPQMSSTGTVHITVTDQNDNPSEPRAVDIFVHYYGNLFPGGTLGSVKPQDPDVLDSFHCS 3638

Human  3653 LTSGVTSLFSIPGGTCDLNSQPRSTDGTFDLTVLSNDGVHSTVTSNIRVFFAGFSNATVDNSILL 3717
            |||||||||:||..:||||||.|||||||||||.|:||:||.||:|:|||||||||||:|||:||
Frog  3639 LTSGVTSLFNIPADSCDLNSQSRSTDGTFDLTVHSSDGLHSPVTNNVRVFFAGFSNATIDNSVLL 3703

Human  3718 RLGVPTVKDFLTNHYLHFLRIASSQLTGLGTAVQLYSAYEENNRTFLLAAVKRNHNQYVNPSGVA 3782
            ||.|.|||||||||||||||||||||||||||||:|..|||||||||:.||||..|||||||||.
Frog  3704 RLNVATVKDFLTNHYLHFLRIASSQLTGLGTAVQIYGVYEENNRTFLMTAVKRGGNQYVNPSGVG 3768

Human  3783 TFFESIKEILLRQSGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQP 3847
            ||||||||||||||||.:||||||||.:.||.||||||||||||.:.|..||:||||||||||:.
Frog  3769 TFFESIKEILLRQSGVWIESVDHDSCSYNPCHNGGSCLRRLAVSPLTKVLESVPVIIVANEPLKT 3833

Human  3848 FLCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCK 3912
            |:|:|:|||.|.:||.|||||||.|||:|||||||||||||||||||||.||||||||||.:|||
Frog  3834 FMCRCMPGYEGEFCETDIDECLPLPCHNGGTCHNLVGGFSCSCPDGFTGIACERDINECLSTPCK 3898

Human  3913 NGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCEL 3977
            |||:||||||.||||||.|.|||:|||:||||||||||||.|||||||.||||||||||||||||
Frog  3899 NGAVCQNFPGGFNCVCKAGSTGKLCESAVNYCECNPCFNGASCQSGVDGYYCHCPFGVFGKHCEL 3963

Human  3978 NSYGFEELSYMEFPSLDPNNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYN 4042
            ||||||||||||||||||||||||:||:|||::.|||||||||||:.||||||||.|||:|.|||
Frog  3964 NSYGFEELSYMEFPSLDPNNNYIYIKFSTIKTNGLLLYNYDNQTGEGAEFLALEIVEERMRLSYN 4028

Human  4043 LGSGTYKLTTMKKVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPN 4107
            ||||||:||||||||||.|||||||||||:||||||:|||.|||||||||..|:|.|||||||||
Frog  4029 LGSGTYRLTTMKKVSDGQFHTVIARRAGMSASLTVDTCSEEQEPGYCTVSTAALSTDWTLDVQPN 4093

Human  4108 RVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSP 4172
            |:||||||||||||||||.|:||||||||||||||||||||||||:||||||:|||:|||||.|.
Frog  4094 RITVGGIRSLEPILQRRGQVQSHDFVGCIMEFAVNGRPLEPSQALSAQGILDRCPRVEGACTISM 4158

Human  4173 CQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRG 4237
            ||:||||:|.||||||:||:|.|||:|||.:|.|||||||.||.|:|.:||:.|||:|::.  |.
Frog  4159 CQNGGTCVDNWSWQQCNCKDGFTGKHCEKYMTADTALSLESKGYLEYTLSQSRKREFLIKP--RS 4221

Human  4238 AMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVA 4302
            |..:...||.||:|||||||||:|:||.||||||.:|:|||||::|||||:|||||||:||:|:|
Frog  4222 ADSDLIFVNQLEIKFRTRSENGLLLHIHESSNYTIIKVKNGKVHYTSDAGVAGKVERNVPEIYIA 4286

Human  4303 DGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTISLGGIPPNQAHRDAQTAGFDGC 4367
            ||.|||..:.|||:.|.||:|:.|::|:.|.|||||||:||.:.||||.|....:.:.. ||:||
Frog  4287 DGRWHTLFMEKNGSTTSLSIDKAYSKDVHHITQDFGGLNVLKMQLGGIQPGSLSQSSHN-GFEGC 4350

Human  4368 IASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYRCVPPGDC 4432
            ||.:.|..|.|||||||:..||||:|.:.|||||||||||||||||||:|||||:||.|||||||
Frog  4351 IAYVKYNKEILPFSGKHNTVSISKSDSAAKIGCRGPNICASNPCWGDLMCINQWHAYSCVPPGDC 4415

Human  4433 ASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPAGHVCVLSQGP 4497
            :|.||.|||||||...|||||.||:|:||..||.||||:|::||||.:||:|...||||||:...
Frog  4416 SSSPCLNGGSCEPNSQSGFTCICPESYTGNLCETVVACVGIVCPQGNICKSGIHGGHVCVLNTHA 4480

Human  4498 EEISLPLWAVPAIVGSCATVLALLVLSLILCNQCRGKKAKNPKEEKKPKEKKKKGSENVAFDDPD 4562
            |||||||||||||||||||:||||||||||||||||:|||.|.:|||||||||||||||||||||
Frog  4481 EEISLPLWAVPAIVGSCATILALLVLSLILCNQCRGRKAKVPNDEKKPKEKKKKGSENVAFDDPD 4545

Human  4563 NIPPYGDDMTVRKQPEGNPKPDIIERENPYLIYDETDIPHNSETIPSAPLASPEQEIEHYDIDNA 4627
            ||||||||||:|||||||||||||||||||||||||||.||:|.|||||||.|:.|||||||:||
Frog  4546 NIPPYGDDMTIRKQPEGNPKPDIIERENPYLIYDETDISHNTEIIPSAPLAVPDTEIEHYDIENA 4610

Human  4628 SSIAPSDADIIQHYKQFRSHTPKFSIQRHSPLGFARQSPMPLGASSLTYQPSYGQGLRTSSLSHS 4692
            |||||||||||||||||||||||||||||||||||||||:||||||||||.||.|||||::|.|:
Frog  4611 SSIAPSDADIIQHYKQFRSHTPKFSIQRHSPLGFARQSPLPLGASSLTYQSSYSQGLRTATLGHA 4675

Human  4693 ACPTPNPLSRHSPAPFSKSSTFYRNSPARELHLPIRDGNTLEMHGDTCQPGIFNYATRLGRRSKS 4757
            .||.||||||||||||||||||||:||||:|||..|:|:.|:||.|.||||||||||||||||||
Frog  4676 GCPPPNPLSRHSPAPFSKSSTFYRSSPARDLHLSRREGSPLDMHNDVCQPGIFNYATRLGRRSKS 4740

Human  4758 PQAMASHGSRPGSRLKQPIGQIPLESSPPVGLSIEEVERLNTPRPRNPSICSADHGRSSSEEDCR 4822
            ||.||.|.|||||||||||||||||:.|||||||||||||||||||||||||||||||||||||:
Frog  4741 PQTMAGHSSRPGSRLKQPIGQIPLETGPPVGLSIEEVERLNTPRPRNPSICSADHGRSSSEEDCQ 4805

Human  4823 RPLSRTRNPADGIPAPESSSDSDSHESFTCSEMEYDREKPMVYTSRMPKLSQVNESDADDEDNYG 4887
            |||||.||||||||||:||||||||||||||||||||:||||||||||||:||||||||||||||
Frog  4806 RPLSRVRNPADGIPAPDSSSDSDSHESFTCSEMEYDRDKPMVYTSRMPKLTQVNESDADDEDNYG 4870

Human  4888 ARLKPRRYHGRRAEGGPVGTQAAAPGTADNTLPMKLGQQAGTFNWDNLLNWGPGFGHYVDVFKDL 4952
            :|||||||.||||||||    |.|...||:||||||.||||.|||||||||||||||||||||||
Frog  4871 SRLKPRRYPGRRAEGGP----ATATLPADSTLPMKLSQQAGNFNWDNLLNWGPGFGHYVDVFKDL 4931

Human  4953 ASLPEKAAA--NEEGKAGTTKPVPKDGEAEQYV 4983
            |||||||.|  |:.|.|..|  |||||:.||||
Frog  4932 ASLPEKATASDNDGGSAANT--VPKDGDTEQYV 4962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FAT4	NP_001278232.1	Cadherin_repeat	48..131	CDD:206637	66/82 (80%)
		Cadherin_repeat	139..246	CDD:206637	83/106 (78%)
		Cadherin_repeat	254..349	CDD:206637	62/94 (66%)
		Cadherin_repeat	364..471	CDD:206637	90/106 (85%)
		Cadherin_repeat	479..577	CDD:206637	67/97 (69%)
		Cadherin_repeat	588..685	CDD:206637	58/101 (57%)
		Cadherin_repeat	693..789	CDD:206637	69/95 (73%)
		Cadherin_repeat	798..889	CDD:206637	65/90 (72%)
		Cadherin_repeat	899..992	CDD:206637	68/92 (74%)
		Cadherin_repeat	1000..1096	CDD:206637	76/95 (80%)
		Cadherin_repeat	1105..1206	CDD:206637	65/100 (65%)
		Cadherin_repeat	1215..1311	CDD:206637	68/95 (72%)
		Cadherin_repeat	1321..1416	CDD:206637	85/94 (90%)
		Cadherin_repeat	1428..1525	CDD:206637	77/96 (80%)
		Cadherin_repeat	1540..1622	CDD:206637	62/81 (77%)
		Cadherin_repeat	1634..1736	CDD:206637	81/101 (80%)
		Cadherin_repeat	1747..1837	CDD:206637	84/89 (94%)
		Cadherin_repeat	1845..1940	CDD:206637	76/94 (81%)
		Cadherin_repeat	1948..2047	CDD:206637	69/98 (70%)
		Cadherin_repeat	2057..2150	CDD:206637	71/92 (77%)
		Cadherin_repeat	2159..2254	CDD:206637	60/94 (64%)
		Cadherin_repeat	2263..2360	CDD:206637	65/96 (68%)
		Cadherin_repeat	2369..2464	CDD:206637	64/94 (68%)
		Cadherin_repeat	2472..2559	CDD:206637	68/86 (79%)
		Cadherin_repeat	2573..2667	CDD:206637	64/93 (69%)
		Cadherin_repeat	2675..2771	CDD:206637	62/95 (65%)
		Cadherin_repeat	2778..2870	CDD:206637	69/91 (76%)
		Cadherin_repeat	2878..2981	CDD:206637	78/102 (76%)
		Cadherin_repeat	2990..3085	CDD:206637	67/94 (71%)
		Cadherin_repeat	3095..3192	CDD:206637	67/96 (70%)
		Cadherin_repeat	3201..3295	CDD:206637	78/93 (84%)
		Cadherin_repeat	3305..3402	CDD:206637	81/96 (84%)
		Cadherin_repeat	3410..3508	CDD:206637	79/97 (81%)
		Cadherin_repeat	3516..3612	CDD:206637	78/95 (82%)
		EGF_CA	3864..3900	CDD:238011	32/35 (91%)
		EGF_CA	3902..3938	CDD:238011	28/35 (80%)
		EGF_CA	3941..3976	CDD:238011	32/34 (94%)
		LamG	3979..4142	CDD:238058	140/162 (86%)
		EGF	4168..4198	CDD:278437	21/29 (72%)
		LamG	4247..4368	CDD:238058	74/120 (62%)
		EGF_CA	4431..4465	CDD:238011	22/33 (67%)
fat4	XP_004911174.2	Cadherin_repeat	40..123	CDD:206637	66/82 (80%)
		Cadherin_repeat	131..238	CDD:206637	83/106 (78%)
		Cadherin_repeat	246..340	CDD:206637	62/94 (66%)
		Cadherin_repeat	355..456	CDD:206637	90/106 (85%)
		Cadherin_repeat	467..560	CDD:206637	67/94 (71%)
		Cadherin_repeat	575..672	CDD:206637	58/99 (59%)
		Cadherin_repeat	680..776	CDD:206637	69/95 (73%)
		Cadherin_repeat	784..876	CDD:206637	65/91 (71%)
		Cadherin_repeat	896..979	CDD:206637	61/82 (74%)
		Cadherin_repeat	987..1083	CDD:206637	76/95 (80%)
		Cadherin_repeat	1092..1193	CDD:206637	65/100 (65%)
		Cadherin_repeat	1202..1298	CDD:206637	68/95 (72%)
		Cadherin_repeat	1308..1403	CDD:206637	85/94 (90%)
		Cadherin_repeat	1415..1512	CDD:206637	77/96 (80%)
		Cadherin_repeat	1527..1609	CDD:206637	62/81 (77%)
		Cadherin_repeat	1621..1723	CDD:206637	81/101 (80%)
		Cadherin_repeat	1734..1824	CDD:206637	84/89 (94%)
		Cadherin_repeat	1832..1927	CDD:206637	76/94 (81%)
		Cadherin_repeat	1935..2034	CDD:206637	69/98 (70%)
		Cadherin_repeat	2044..2137	CDD:206637	71/92 (77%)
		Cadherin_repeat	2145..2241	CDD:206637	60/95 (63%)
		Cadherin_repeat	2250..2347	CDD:206637	65/96 (68%)
		Cadherin_repeat	2357..2450	CDD:206637	64/93 (69%)
		Cadherin	2459..2544	CDD:394985	66/84 (79%)
		Cadherin_repeat	2561..2653	CDD:206637	64/91 (70%)
		Cadherin_repeat	2661..2757	CDD:206637	62/95 (65%)
		Cadherin_repeat	2764..2856	CDD:206637	69/91 (76%)
		Cadherin_repeat	2870..2967	CDD:206637	73/96 (76%)
		Cadherin_repeat	2976..3071	CDD:206637	67/94 (71%)
		Cadherin_repeat	3083..3178	CDD:206637	66/94 (70%)
		Cadherin_repeat	3186..3281	CDD:206637	78/94 (83%)
		Cadherin_repeat	3291..3388	CDD:206637	81/96 (84%)
		Cadherin_repeat	3396..3494	CDD:206637	79/97 (81%)
		Cadherin_repeat	3504..3598	CDD:206637	77/93 (83%)
		EGF	3794..3846	CDD:394967	35/51 (69%)
		EGF_CA	3850..3886	CDD:238011	32/35 (91%)
		EGF_CA	3888..3924	CDD:238011	28/35 (80%)
		EGF_CA	3927..3962	CDD:238011	32/34 (94%)
		LamG	3965..4128	CDD:238058	140/162 (86%)
		EGF_CA	4155..4186	CDD:238011	21/30 (70%)
		Laminin_G_2	4236..4359	CDD:396680	75/123 (61%)
		EGF_CA	4414..4448	CDD:238011	22/33 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	916	1.000	Domainoid score	I847
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14377
Inparanoid	1	1.050	7576	1.000	Inparanoid score	I13
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52424
OrthoDB	1	1.010	-	-		D1530at32523
OrthoFinder	1	1.000	-	-		FOG0001195
OrthoInspector	1	1.000	-	-		oto147797
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6394
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980