Protein Alignment NDNF and nord

DIOPT Version :10

• Sequence 1: NP_078850.3
• Gene: NDNF / 79625
• HGNCID: 26256
• Length: 568
• Species: Homo sapiens
• Sequence 2: NP_611900.1
• Gene: nord / 37882
• FlyBaseID: FBgn0050418
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 137/613 - (22%)
• Similarity: 229/613 - (37%)
• Gaps: 163/613 - (26%)

Human    20 QKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTP--------KRYFFVVE-EDNTPL 75
            ||.|:.  :.::..::|   |.|   :.|       |:.|.|        :|..||:. .|:|||
  Fly    65 QKCPSL--QRYRKMLKD---FDD---LED-------LYVDVPVHIALAERQRKRFVLNLNDSTPL 114

Human    76 SVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINEEGTEL-----FSYKGNDVEY 135
            ::..:   ||:..|:                          ..|:.|..|     ....|..|..
  Fly   115 TIRFS---APVGRKM--------------------------YYNQTGNPLRPAAVAPGPGVAVGS 150

Human   136 FISSSSPSGLYQLDLLSTEKDTHFKVYATTT-PESDQPYPELPYDPRVDVTSLGRT---TVTLAW 196
            .:...:..|.|.|.:|:..... .||.|... |:.|  :|.|....|:.:.:..|.   .:.:.|
  Fly   151 LVLPCALRGQYDLFVLARHSGA-LKVDALAEHPQHD--WPLLNATHRIAIRTQNRVRKREMIVKW 212

Human   197 KPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDA------FMMAPKPGLDFSPFDFAHF 255
            :.|   ......:.||:||.             :||.|..      |..|.....|..|..
  Fly   213 ERS---KFDFHVMHYCLVIQ-------------RLSMDTPRMIFTNFCQAVSAYTDQQPMT---- 257

Human   256 GFPSDNSG--KERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVV- 317
              ||..:|  .|..:.|.|.    |.....|:.::..:|.|.:....:..|.|.:.|:.|:|.:
  Fly   258 --PSCAAGGPLEGIWGAPPQ----RERRLNPRQNVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIH 316

Human   318 ----NINSNMSTAYVGTFARTKEEA--KQKTVELKDGKITDVFVKRKGAKFLRF-APVSSHQKVT 375
                |:...::::.| .|.||:..|  :|..::||.|       .:.|.:...| .|.::.|...
  Fly   317 QGRQNLTLRLASSQV-NFNRTQPLALKQQALMQLKIG-------GQHGKQVYSFKVPQTTRQLGE 373

Human   376 FFIHSCL---DAVQIQVRRDGKLLLSQNVEG-IQQF----QLRGK---PKAKYLVRLKGNKKG-- 427
            .|:...|   ...:|:|    |||..::..| .:.|    .:|.|   |..:||:|.:.:...
  Fly   374 PFMRHLLIPCSGSEIRV----KLLRQRSEVGKTEAFYSPTYIRQKGVLPGERYLMRFEPSNDDEA 434

Human   428 --ASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNK--FCIYKKEVDDN 488
              |..:.:..::....:..|.||::|.:  |:....||.||:||.|:.:..:  :||..
  Fly   435 LRAQKVMVALSSEALFRDLPELPQNTTV--FNVRTRCSRATIAWNGSPDERELSYCIIV------ 491

Human   489 YNEDQKKRE----QNQCLGPDIRKKS-------EKVLCKYFHSQNLQKAVTTETIKGLQPGKSYL 542
            :|..|:.|.    .|.|:  |...|.       |.:.|:  ..|.....:.||||..|.||.|||
  Fly   492 FNLPQRNRSVVDFTNYCM--DFVPKRVMQYRYFEWMTCR--ERQQSPDNIETETILNLMPGSSYL 552

Human   543 LDVYVIGH--GGHSVKYQSKVVKTRKFC 568
              |||..:  .|..:.||:..:.....|
  Fly   553 --VYVTANLSMGKPLPYQALTLHMASQC 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NDNF	NP_078850.3	NDNF	192..335	CDD:462981	32/155 (21%)
		NDNF_C	394..568	CDD:466079	52/200 (26%)
nord	NP_611900.1	NDNF	208..333	CDD:462981	30/151 (20%)
		NDNF_C	418..568	CDD:466079	43/163 (26%)