DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF128 and HRD1

DIOPT Version :9

Sequence 1:	NP_919445.1	Gene:	RNF128 / 79589	HGNCID:	21153	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_014630.1	Gene:	HRD1 / 854149	SGDID:	S000005373	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	205	Identity:	44/205 - (21%)
Similarity:	70/205 - (34%)	Gaps:	78/205 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   273 DGDSCAVCIE--LYKPNDLV--------RILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGI 327
            |.:.|.:|::  ::.||...        :.|.|.||.|.:|:..|:...:|||:|:..:....|.
Yeast   345 DDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGN 409

Human   328 EVD---VEDGSVSLQVPV-------------SNEI----------------------------SN 348
            .|.   ..:..::.|..|             :||:                            |.
Yeast   410 VVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRST 474

Human   349 SASS--------HEE-DNRSETASSGYA-SVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVD-- 401
            |..|        |:. ||...::.|.|. .:..:||......|:.|.|     |||.||:..|
Yeast   475 STPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIE-----NHEVNSLHGDGG 534

Human   402 -------VIP 404
                   |||
Yeast   535 EQIAKKIVIP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037
		RING-H2_RNF128_like	275..323	CDD:319716	15/57 (26%)
		RING-H2 finger (C3H2C3-type)	277..317	CDD:319716	14/49 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..428		22/106 (21%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	44/205 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910