DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF128 and gol

DIOPT Version :9

Sequence 1:	NP_919445.1	Gene:	RNF128 / 79589	HGNCID:	21153	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	105/304 - (34%)
Similarity:	160/304 - (52%)	Gaps:	43/304 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    45 AYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLV---PPDGPGALNACNPHTNFTVPT 106
            |:||.|: |.|..:...:....|:..||:...|. |.|.|:   ..|......||.|:...|:
  Fly    70 AFLNWSY-VEHGNMLCNMEFAQEQARYGEGKVLN-VTGRLIHITATDNFSDDYACTPYIRGTL-- 130

Human   107 VWGSTVQ---VSWLALIQRGGGCTFADKIHLAYERGASGAVIFN-----------FPG-TRNEVI 156
              |:.:.   .:|:||::| |.|||.:|:...|::.|:|.:|:|           ..| |||
  Fly   131 --GAPIPDKGETWIALVRR-GRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRN--- 189

Human   157 PMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWV---NHYSIFFVSVSFFII 218
                     |.|::.....|..:..::.:|..||:.|..|::....:   |..|:.|||:||.::
  Fly   190 ---------IAAVITYQNIGQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVL 245

Human   219 TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGD-KEIGPDGDSCAVCIE 282
            ...::.:.|||..:|.|..:|:.::.|.|.:..||||.::..:|.|..| |::  |.|.||:|||
  Fly   246 MIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSDEKDL--DSDCCAICIE 308

Human   283 LYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG 326
            .|||.|.:|||.|.|.|||.|:||||:|||||||||.|:||..|
  Fly   309 AYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDVLKFYG 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037	41/162 (25%)
		RING-H2_RNF128_like	275..323	CDD:319716	33/47 (70%)
		RING-H2 finger (C3H2C3-type)	277..317	CDD:319716	28/39 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..428
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	41/162 (25%)
		UPF0233	226..>258	CDD:299753	10/31 (32%)
		zf-RING_2	301..344	CDD:290367	30/42 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7982
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3586
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41809
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.030