DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF128 and SPAC57A7.09

DIOPT Version :9

Sequence 1:	NP_919445.1	Gene:	RNF128 / 79589	HGNCID:	21153	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_593372.1	Gene:	SPAC57A7.09 / 2542187	PomBaseID:	SPAC57A7.09	Length:	372	Species:	Schizosaccharomyces pombe

Alignment Length:	346	Identity:	72/346 - (20%)
Similarity:	134/346 - (38%)	Gaps:	85/346 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    43 WTAYLNVSWRVPHTGVNRTVWELSEEGVYGQ---DSPLEPVAGVLVPPDGPGALNACNPHTNFTV 104
            :.|..:|:.::|...|  |:|  |.:.|:|:   ::....|..:.:|.:....::.| |:.|.|.
pombe    39 FAASTDVAIQLPDRNV--TLW--SRQAVFGKHFTNASATTVINLYLPSNFQEDMSGC-PNRNDTD 98

Human   105 PTVW----------------------GSTVQ-----------VSWLALIQRGGGCTFADKIHLAY 136
            .:.:                      .:.||           :....|:|| |.||:.||...|.
pombe    99 ASYFYENDIIDYDIEYIEQKSYSSKPSARVQKDDGGESKDEAILDFLLVQR-GKCTYFDKALEAQ 162

Human   137 ERGASGAVI-FNFPGTRNEVIPMSHPGAVD-----IVAIMIG----NLKGTKILQSIQRGIQV-T 190
            ..|..|.:: .|...:...:..|..|..||     |.::.:.    ||..:.:|.|.::.::: .
pombe   163 RLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLKLYA 227

Human   191 MVIEVGKKHGPWVNHYS---IFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAK 252
            ...|:|....|::..:|   |..::|.     |..:..||       |..|.:|:.:|.::....
pombe   228 KPEELGDMFWPFLLCFSPSIIMLITVQ-----ALAIRKFI-------RTYRTKSKTRRFIEDLPS 280

Human   253 KAIGRL----------------QLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHK 301
            :.|.|.                :|..|..........|..|.:|:|.:...|.|..|.|.|.||:
pombe   281 RTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTKGDKVVALPCKHEFHR 345

Human   302 TCVDPWLLEHR-TCPMCKCDI 321
            .|:..|::::| .||.|..::
pombe   346 PCIAKWIVDYRHACPTCNTEV 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037	37/191 (19%)
		RING-H2_RNF128_like	275..323	CDD:319716	16/48 (33%)
		RING-H2 finger (C3H2C3-type)	277..317	CDD:319716	15/40 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..428
SPAC57A7.09	NP_593372.1	COG5540	1..369	CDD:227827	72/346 (21%)
		Peptidases_S8_S53	<144..211	CDD:299169	18/67 (27%)
		zf-RING_2	320..362	CDD:290367	15/41 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm53615
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810