DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF128 and H10E21.5

DIOPT Version :9

Sequence 1:	NP_919445.1	Gene:	RNF128 / 79589	HGNCID:	21153	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	224	Identity:	79/224 - (35%)
Similarity:	117/224 - (52%)	Gaps:	52/224 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   207 SIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQG-DKEI 270
            |:.|||:||.|:...::.:.:||..:|.|.|.|:.|.||:|...|:||:.|:...|:..| .:|:
Worm   159 SVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPGMTQEL 223

Human   271 GPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDV---- 331
            ..|   ||||::.|:..|::|:|.|.||:||:|:||||||||||||||.||||..|...|:
Worm   224 QSD---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGYWNDIRNDI 285

Human   332 ----------EDGSVSL-------QVPVSNEISNSASSHEEDNRS---------ETASSGYASVQ 370
                      :|.::.|       |.|.::.||..|:|...|::.         .:.|.||
Worm   286 QMPTNSRGIADDFTIRLELGEQEHQAPSADVISPEANSDTSDSQGFSFDNSEHHHSESFGY---- 346

Human   371 GTDE--PPLEEHVQSTNESLQLVNHEANS 397
            ||..  ||            |||.:.:|:
Worm   347 GTSSTVPP------------QLVLNASNA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037
		RING-H2_RNF128_like	275..323	CDD:319716	30/47 (64%)
		RING-H2 finger (C3H2C3-type)	277..317	CDD:319716	25/39 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..428		16/63 (25%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	67/168 (40%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	31/49 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I5756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm15229
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.970