DRSC/TRiP Functional Genomics Resources

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Protein Alignment CORO7 and CRN1

DIOPT Version :10

Sequence 1:NP_078811.3 Gene:CORO7 / 79585 HGNCID:26161 Length:925 Species:Homo sapiens
Sequence 2:NP_013533.1 Gene:CRN1 / 851148 SGDID:S000004421 Length:651 Species:Saccharomyces cerevisiae


Alignment Length:511 Identity:153/511 - (29%)
Similarity:251/511 - (49%) Gaps:67/511 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   470 SSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPL-LSSGGQVAVLELRKPGRL 533
            :||:||..|....::.....||..|  ...:|:....|...:||.. .|.||..||:.:.:.|:.
Yeast     8 ASKYRHVFGQAAKKELQYEKLKVTN--NAWDSNLLKTNGKFIAVNWNASGGGAFAVIPIEEVGKA 70

Human   534 PDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPA---------EGLEEVLTTPETV 589
            ||.......:.|.|.|..:|||:.||:|...:|::|.:|.:|.         |..|.:...|...
Yeast    71 PDQVPLFRGHTAQVLDTDFDPFNDHRIASGSDDSKIGIWDIPENYKFHDHVDEDGEPIDIKPVKF 135

Human   590 LTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLAT 654
            ||||..|:..:.:||:|.|||||||.|.||::|:::.|.|.:.|: |.|.:.|:::|.||..|||
Yeast   136 LTGHARKVGHVLYHPVAENVLASSSGDYTVKLWNVETGKDMITLK-HPDMVTSMSFSYDGNYLAT 199

Human   655 VCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAG 719
            |.:|.::||:..|. .:.:.|||...|.:..|:||:.:...|..:||...|:||:.:::|..:..
Yeast   200 VARDKKLRVWNIRE-EKIVSEGPAHTGAKNQRVVWLGNSDRLATTGFSKLSDRQIGIWDAFNIEK 263

Human   720 GPL-AVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHKGLV 783
            |.| ....:|.:...|:|.||....::.|.||||..:..||...:..|  |.:.|.|.:..:|..
Yeast   264 GDLGGFYTVDQSSGILMPFYDEGNKILYLVGKGDGNIRYYEFQNDELF--ELSEFQSTEAQRGFA 326

Human   784 LLPKTECDVREVELMRCLR-LRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLSAEAWLQG 847
            :.||...:|:|.|:::..: :....:|||:|.:|| |.|.||:|::|| |...:|.|:||.|..|
Yeast   327 VAPKRMVNVKENEVLKGFKTVVDQRIEPVSFFVPR-RSEEFQEDIYPD-APSNKPALTAEEWFSG 389

Human   848 ANGQ-PWLLSL--------------------------------QPPDMSPVSQAPREAPARRAPS 879
            .:.: |.|:|:                                ||....|:|::.:|. .:.||.
Yeast   390 KSVEGPILVSMRSIYDGSAPSFHEAKRPQQPTTQETALEEKKEQPKVEKPISESEKEV-KQEAPK 453

Human   880 SAQYLEEKSDQQ------KKEELLNAMVAK------LGNREDPLPQDS-FEGVDED 922
            |...|:..|...      |::..:|.::.|      :.|.|||....| :|..|::
Yeast   454 SPSPLKSASSSSTINHVLKEDNSINKLLKKSSDIDQVNNAEDPSRDTSGWEEADDE 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CORO7NP_078811.3 WD40 6..428 CDD:475233
WD 1 75..115
WD40 repeat 81..124 CDD:293791
WD 2 124..163
WD40 repeat 129..165 CDD:293791
WD 3 166..205
WD40 repeat 172..208 CDD:293791
WD 4 209..253
WD40 repeat 215..256 CDD:293791
WD40 repeat 263..302 CDD:293791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..461
WD40 471..880 CDD:475233 140/453 (31%)
WD40 repeat 504..540 CDD:293791 11/36 (31%)
WD 5 542..582 15/48 (31%)
WD40 repeat 547..591 CDD:293791 15/52 (29%)
WD 6 592..632 19/39 (49%)
WD40 repeat 598..634 CDD:293791 16/35 (46%)
WD 7 635..674 14/38 (37%)
WD40 repeat 640..677 CDD:293791 13/36 (36%)
WD 8 728..768 13/39 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 858..925 20/78 (26%)
CRN1NP_013533.1 WD40 repeat 228..270 CDD:293791 12/41 (29%)
WD40 repeat 278..315 CDD:293791 13/38 (34%)
PTZ00449 <422..>603 CDD:185628 20/89 (22%)
WD40 9..424 CDD:475233 133/422 (32%)
WD40 repeat 85..138 CDD:293791 15/52 (29%)
WD40 repeat 143..179 CDD:293791 16/35 (46%)
WD40 repeat 186..221 CDD:293791 13/35 (37%)
Blue background indicates that the domain is not in the aligned region.

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