Protein Alignment CORO7 and coro7

DIOPT Version :10

• Sequence 1: NP_078811.3
• Gene: CORO7 / 79585
• HGNCID: 26161
• Length: 925
• Species: Homo sapiens
• Sequence 2: NP_001025407.2
• Gene: coro7 / 569563
• ZFINID: ZDB-GENE-050706-137
• Length: 923
• Species: Danio rerio
• Alignment Length: 939
• Identity: 529/939 - (56%)
• Similarity: 690/939 - (73%)
• Gaps: 31/939 - (3%)

Human     1 MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRP--GVLGIVPLQGQ 63
            ||||:.||:::|..:.|:::.||:::|.|:..|...||||||||:|||:|..  |::|:..:...
Zfish     1 MNRFKTSKYKNTTPKIPKKDGWIANVRGGSFSSQGKHIKSSCSLVAFNTDHAGGGMVGLSSVNAG 65

Human    64 GEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLP 128
            .:.|..|..:.||:|||||||||||||:||||.|||:|||||||....|..||...|.|.|.|..
Zfish    66 ADGKWSVTQISCHADLVTDLDFSPFDDYLLATCSADQTVKLWRLWDVDQDQPSNAEVTLSPADGR 130

Human   129 VEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLR 193
            :|:|.|||.:..:|..|:...|::||..:...||.|..|.|.:|...|..||:|:.::||||:||
Zfish   131 LELLLFHPAASALLAVASAGGVQLWDINRDSALTVLEPHADQLQGLSWKEDGSLLASSCKDKKLR 195

Human   194 IFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLD 258
            :||||.:|.|.|..|||:.:||||:.|:.. ::|::|||||:|::||:|||:|..:|::::|:|.
Zfish   196 LFDPRAQPSAVQCVQAHQGNRDSRVLWVKD-DNLLTTGFNQVRQQEVRLWDSRKLTSSVSALSLA 259

Human   259 TSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVM 323
            ||...|:||.|.|||||:|:|.||..:.|:||...:|.||.|:|||.:|..||..|:|:.||.:.
Zfish   260 TSNSTLIPLFDSDSGLLILSGNGESVIDCFEVNTSEPFLSQVSQCVADSSSRGVCLLPKLALDIS 324

Human   324 SCEVLRVLQLSDTAIVPIGYHVPRKA-VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNP 387
            .|||||::||::..||||.|.||||| .:||.||:|||.|...|.....||.|||:||::|||:|
Zfish   325 CCEVLRLMQLTENFIVPISYQVPRKAGQDFHADLYPDTVGHTAAMSADEWWKGDNKQVERVSLHP 389

Human   388 ACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVGD---ADASEGFSSPPSSLTSPSTPSSLGPSLS 449
            :.||.|                |.|:..|....|   ..:.|..||..|.|:|||:.:....|.|
Zfish   390 SKRPKP----------------AAPSAQEKAQKDLSRGKSKEEASSSSSPLSSPSSSAVPSRSPS 438

Human   450 STSGIGT--------SPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCA 506
            ||||:.:        |.|.|::.::|||||||||.||:|||||:|||||:||:||||||.|||||
Zfish   439 STSGLSSGFVPSPSPSQSSRAIHNMLGPSSKFRHIQGSVLHRDTHITNLRGLHLTTPGECDGFCA 503

Human   507 NKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRL 571
            |..||||||..:|||:||.||.:||:||||||||:||...|.|..|||||||||.|||:||:||:
Zfish   504 NGQRVAVPLAIAGGQIAVFELSQPGKLPDTALPTIQNSVNVADFCWDPFDPHRLVVAGDDAKIRV 568

Human   572 WRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGH 636
            |::|..||:|.||.||.||.||||||.|::|||.|..:|.|||||||||:|.|:.|....:|.||
Zfish   569 WQIPKGGLQETLTEPECVLRGHTEKIYSVKFHPHAIGLLVSSSYDLTVRLWSLETGEQVKQLSGH 633

Human   637 QDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGF 701
            |||||.:||||||:.||||||||:||:|.||....|:||||||:|.||||:||||.|:.|:||||
Zfish   634 QDQIFGMAWSPDGKLLATVCKDGKVRLYDPRKSTSPIQEGPGPEGQRGARVVWVCGGKFLMVSGF 698

Human   702 DSQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPF 766
            ||:|||||.|:.||:||.|.||....||:||||:|.|||||.:::|||||||||::||::||:|:
Zfish   699 DSRSERQLYLFSAESLASGSLASAPADVSPSTLIPFYDPDTSVLILTGKGDTRVYIYEIVPEAPY 763

Human   767 FLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDT 831
            |:||:||.|.:|||||..|||||||||:||:.|.:||.::::||||||:|||:||||||||||||
Zfish   764 FMECSSFNSSEPHKGLCFLPKTECDVRDVEVARAVRLGKTTIEPVAFRVPRVKKEFFQDDVFPDT 828

Human   832 AVIWEPVLSAEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEEL 896
            ||.||..|||..||.|::||...:||:|.||:|||:||:|||.|:...|:.|||||:|:||||||
Zfish   829 AVWWESSLSAADWLSGSDGQHRKISLRPKDMTPVSEAPKEAPVRKYLPSSVYLEEKTDEQKKEEL 893

Human   897 LNAMVAKLGNREDPLPQDSFEGVDEDEWD 925
            |:|||||||||||||||:|:|||||||||
Zfish   894 LSAMVAKLGNREDPLPQESYEGVDEDEWD 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CORO7	NP_078811.3	WD40	6..428	CDD:475233	195/427 (46%)
		WD 1	75..115		30/39 (77%)
		WD40 repeat	81..124	CDD:293791	29/42 (69%)
		WD 2	124..163		13/38 (34%)
		WD40 repeat	129..165	CDD:293791	12/35 (34%)
		WD 3	166..205		19/38 (50%)
		WD40 repeat	172..208	CDD:293791	18/35 (51%)
		WD 4	209..253		21/43 (49%)
		WD40 repeat	215..256	CDD:293791	18/40 (45%)
		WD40 repeat	263..302	CDD:293791	20/38 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..461		17/52 (33%)
		WD40	471..880	CDD:475233	271/408 (66%)
		WD40 repeat	504..540	CDD:293791	25/35 (71%)
		WD 5	542..582		24/39 (62%)
		WD40 repeat	547..591	CDD:293791	28/43 (65%)
		WD 6	592..632		24/39 (62%)
		WD40 repeat	598..634	CDD:293791	18/35 (51%)
		WD 7	635..674		27/38 (71%)
		WD40 repeat	640..677	CDD:293791	24/36 (67%)
		WD 8	728..768		26/39 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	858..925		49/66 (74%)
coro7	NP_001025407.2	None