Protein Alignment CORO7 and pod1

DIOPT Version :10

• Sequence 1: NP_078811.3
• Gene: CORO7 / 79585
• HGNCID: 26161
• Length: 925
• Species: Homo sapiens
• Sequence 2: NP_001245554.1
• Gene: pod1 / 31620
• FlyBaseID: FBgn0029903
• Length: 1266
• Species: Drosophila melanogaster
• Alignment Length: 1267
• Identity: 384/1267 - (30%)
• Similarity: 567/1267 - (44%)
• Gaps: 351/1267 - (27%)

Human     3 RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPG-VLGIVPLQGQGED 66
            ||:.||:::.....|:.|:.:.:|..|:..:..|:|.:|.:.:|||.:..| .:.::||...|..
  Fly     4 RFKASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWEHTGSSVAVLPLDDCGRK 68

Human    67 KRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAPGVVLGPEDLPV 129
            .:.:..|..|:|.||||.||||.|.||||.|.|..||:|.:|..|  |:| |.|..:...:...|
  Fly    69 SKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEKGLEQSL-SDPEAIFSHKQRRV 132

Human   130 EVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRI 194
            |.:.||||:||::.|.|...|.::|.:.|:.:.....|.:::|||.|..||:::.|:||||.:||
  Fly   133 ETVGFHPTADGLMYSTAAGCVALFDLSTQKEIFSNNEHPEVIQSASWREDGSVLATSCKDKNVRI 197

Human   195 FDPRTKPRASQST-QAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLD 258
            ||||......|.| ::|::.:|||:.|:|....:::|||:..|.|:|.:.|.|.|::...:|.||
  Fly   198 FDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIRDVRNFNTPEKTLELD 262

Human   259 TSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVM 323
            .|.|.|:||.|||:.:|.|||||:..:...|:..:.|.|....:...|.. :||.|||::||.||
  Fly   263 CSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRHTGEQT-KGACLVPKRALKVM 326

Human   324 SCEVLRVLQLSDTAIVPIGYHVPRKAV-EFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNP 387
            ..||.|||||:...::||.|.||||.. :||.||:|:|.|.........|..|.||.|.|:||:|
  Fly   327 EAEVNRVLQLTSNMVIPIMYQVPRKTYRDFHADLYPETTGYKTELVAGEWLNGSNQAVPKMSLDP 391

Human   388 ACRPH------------------------------------------------------------ 392
            |.|.|
  Fly   392 AKREHGDEPIIIHRGNLSDFVKNLENQRAKSNTTGKPNQQAKRNDNEHFVMLNTGNNFEEKNGND 456

Human   393 -----------PSFT------SCLV---------------------------------------- 400
                       ||.:      |.|:
  Fly   457 NSNESNGKKSTPSQSQPDGECSELIRKFEAKYKVDSEKEKAHAYAQSHEDDKESPTEHEHSTGSS 521

Human   401 ------------------PPAEPLPDTAQ------------------------------------ 411
                              .|.:|:|.|::
  Fly   522 EEVSSSGGLDNHSASGSHSPPKPMPRTSRSNSLPEASDSAGESSSTNTPRPRPRTTAASAYKPRL 586

Human   412 -PAVMETPVGDADASEGFSSP-------------------------------------------- 431
             |....:..||....:.|:.|
  Fly   587 GPKPFSSTTGDVSFDKVFAVPLAPGSHENISNVGQDSGVEMTPAQGAKPDLIVEIEIKKKHEREP 651

Human   432 -------PSSLTS---------------------------------------------------- 437
                   ..|||:
  Fly   652 AVSGNGVQKSLTTSERRKSSADDDESSDKIFEQNSESSENSTEGEDRTDADLRRNCTSRSSFAER 716

Human   438 ---------------PSTPSSL------------------------------------------- 444
                           |.:|..|
  Fly   717 RRIYENRSKSQVDEKPQSPVPLRREHSKVEPLKPNQQQQQQGNVIDTKRISVPEGKLMEEHRRGN 781

Human   445 --GPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCAN 507
              |...|:|....::.|.:...::.|..|||||.:||..|:.:||.||:.|:...|||.:||.||
  Fly   782 GAGLKKSATEAAFSAASTKRTSTVFGKVSKFRHLKGTPGHKSTHIENLRNLSRQIPGECNGFHAN 846

Human   508 KLRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLW 572
            :.||||||...||::|:.||.:||||||..:|:|.||:.:.|..|||||..|||||.:|..:::|
  Fly   847 QERVAVPLSGPGGKIAIFELSRPGRLPDGVIPSLVNGSNIMDFQWDPFDAQRLAVACDDGIVKIW 911

Human   573 RVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQ 637
            .:.|.||.|...||...||.|.:||..:|||||||:||.::|||:|:::|||:...::..|.||.
  Fly   912 HIEAGGLSEPTNTPAGELTAHLDKIYFIRFHPLAADVLLTASYDMTIKLWDLRTMTEKCSLSGHT 976

Human   638 DQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFD 702
            ||||..||||.|:..|||||||::|||.||....|::||.||.|.|||||.|..:|..::.:|||
  Fly   977 DQIFDFAWSPCGRLGATVCKDGKIRVYNPRKSETPIREGNGPVGTRGARITWALEGHYIVCTGFD 1041

Human   703 SQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFF 767
            ..||||:.:|.|:.|: .||....|||:||.|:|.||.|:..:.:|||||:.::.||:..|.|:.
  Fly  1042 KVSERQISVYNAQKLS-APLNTASLDVSPSILIPFYDEDSSTLFVTGKGDSTIYCYEITDEEPYI 1105

Human   768 LECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTA 832
            ...:.......|:||..|.|..|||..||..:..||..:::||::|.:||::.|.||||:||.|.
  Fly  1106 CPLSHHRCTSLHQGLSFLTKNHCDVASVEFSKAYRLTNTTIEPLSFTVPRIKSELFQDDLFPPTR 1170

Human   833 VIWEPVLSAEAWLQGANGQPWLLSLQPPDM---SPVSQAPREAPARRAPSSAQYLEEKSDQQ--K 892
            :.|...||:|.|....:.....:||:|..|   |.:.|.|.: |.:: |...|:..:||:.:  |
  Fly  1171 ITWSATLSSEDWFASNDKAAPKVSLKPEGMETLSSIQQVPAQ-PVKK-PDHPQFGGQKSEYEINK 1233

Human   893 KEELLNAMVAKLGNREDPLPQDSFEGVDEDEW 924
            ::|:..::.|:: .....|.||..|||||:||
  Fly  1234 QQEIQKSVSARM-EFTTKLEQDDMEGVDENEW 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CORO7	NP_078811.3	WD40	6..428	CDD:475233	165/598 (28%)
		WD 1	75..115		23/41 (56%)
		WD40 repeat	81..124	CDD:293791	23/44 (52%)
		WD 2	124..163		13/38 (34%)
		WD40 repeat	129..165	CDD:293791	13/35 (37%)
		WD 3	166..205		18/38 (47%)
		WD40 repeat	172..208	CDD:293791	19/36 (53%)
		WD 4	209..253		15/43 (35%)
		WD40 repeat	215..256	CDD:293791	14/40 (35%)
		WD40 repeat	263..302	CDD:293791	15/38 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..461		14/204 (7%)
		WD40	471..880	CDD:475233	188/411 (46%)
		WD40 repeat	504..540	CDD:293791	20/35 (57%)
		WD 5	542..582		18/39 (46%)
		WD40 repeat	547..591	CDD:293791	19/43 (44%)
		WD 6	592..632		19/39 (49%)
		WD40 repeat	598..634	CDD:293791	16/35 (46%)
		WD 7	635..674		24/38 (63%)
		WD40 repeat	640..677	CDD:293791	21/36 (58%)
		WD 8	728..768		18/39 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	858..925		23/72 (32%)
pod1	NP_001245554.1	DUF1899	3..67	CDD:462645	17/62 (27%)
		WD40	37..>389	CDD:475233	142/353 (40%)
		WD40 repeat	83..127	CDD:293791	23/44 (52%)
		WD40 repeat	132..166	CDD:293791	13/33 (39%)
		WD40 repeat	174..210	CDD:293791	18/35 (51%)
		WD40 repeat	217..260	CDD:293791	14/42 (33%)
		WD40 repeat	267..294	CDD:293791	12/26 (46%)
		WD40	809..>1193	CDD:475233	179/384 (47%)
		WD40 repeat	884..923	CDD:293791	17/38 (45%)
		WD40 repeat	937..973	CDD:293791	16/35 (46%)
		WD40 repeat	979..1016	CDD:293791	21/36 (58%)
		WD40 repeat	1024..1064	CDD:293791	17/40 (43%)
		WD40 repeat	1071..1094	CDD:293791	10/22 (45%)