DRSC/TRiP Functional Genomics Resources

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Protein Alignment CORO7 and crn1

DIOPT Version :10

Sequence 1:NP_078811.3 Gene:CORO7 / 79585 HGNCID:26161 Length:925 Species:Homo sapiens
Sequence 2:NP_593175.1 Gene:crn1 / 2541961 PomBaseID:SPAC23C4.02 Length:601 Species:Schizosaccharomyces pombe


Alignment Length:492 Identity:158/492 - (32%)
Similarity:241/492 - (48%) Gaps:86/492 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   470 SSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLS------SGGQVAVLELR 528
            :||:||..|....::....|:|..|       :.:.:|.|.|....||      :||.:||:.|.
pombe     8 ASKYRHIFGQTCKKELCYDNIKLSN-------NAWDSNLLSVNPFYLSVNWNAGAGGALAVIPLN 65

Human   529 KPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVP-----AEGLEEVLTTPET 588
            :.|:|||.......:.|||.|..|:||....||..|:|::|.:|:||     .|..|:|  .|..
pombe    66 ERGKLPDQVNLFRGHTAAVLDTDWNPFHDQVLASGGDDSKIMIWKVPEDYTVMEPYEDV--HPIA 128

Human   589 VLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIF-SLAWSPDGQQL 652
            .|.||:.|:..:::||.|||||||||.|.|:::||.:.|...:.|:  .|.:. |::::.||.:|
pombe   129 ELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKGVAHVSLK--MDVMCQSMSFNADGTRL 191

Human   653 ATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEAL 717
            .|..:|.:|||:.||: .:|:..|.|..|.:..|:||:........:||...|:||:.|::...|
pombe   192 VTTSRDKKVRVWDPRT-DKPVSVGNGHAGAKNPRVVWLGSLDRFATTGFSKMSDRQIALWDPTNL 255

Human   718 A---GGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPH 779
            :   ||   ...||.....|:|.:|..|.::.|.||||..:..||.  |:..|...:.|.|.||.
pombe   256 SEPIGG---FTTLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEY--ENDVFHYLSEFKSVDPQ 315

Human   780 KGLVLLPKTECDVREVELMRCLR-LRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLSAEA 843
            :|:..|||...:|.|.|:||..: :..|.:||::|.:|| |.|.||.|::| .|...:|.|:||.
pombe   316 RGIAFLPKRGVNVSENEVMRAYKSVNDSIIEPISFIVPR-RSESFQSDIYP-PAPSGKPSLTAEE 378

Human   844 WLQGANGQPWLLSLQ-----------------------------------PPDMSPVSQAPREAP 873
            |..|.:.||.||.:.                                   .|:..|||: |:|:.
pombe   379 WASGKDAQPDLLDMSTLYESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSK-PKESA 442

Human   874 ARRAPS----------SAQYLEEKS-----DQQKKEE 895
            ..:.||          ||..:||.|     |..:|||
pombe   443 EEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQKEE 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CORO7NP_078811.3 WD40 6..428 CDD:475233
WD 1 75..115
WD40 repeat 81..124 CDD:293791
WD 2 124..163
WD40 repeat 129..165 CDD:293791
WD 3 166..205
WD40 repeat 172..208 CDD:293791
WD 4 209..253
WD40 repeat 215..256 CDD:293791
WD40 repeat 263..302 CDD:293791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..461
WD40 471..880 CDD:475233 149/469 (32%)
WD40 repeat 504..540 CDD:293791 14/41 (34%)
WD 5 542..582 17/44 (39%)
WD40 repeat 547..591 CDD:293791 17/48 (35%)
WD 6 592..632 19/39 (49%)
WD40 repeat 598..634 CDD:293791 16/35 (46%)
WD 7 635..674 13/39 (33%)
WD40 repeat 640..677 CDD:293791 12/37 (32%)
WD 8 728..768 13/39 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 858..925 17/88 (19%)
crn1NP_593175.1 WD40 9..463 CDD:475233 151/473 (32%)
WD40 repeat 85..132 CDD:293791 17/48 (35%)
WD40 repeat 137..172 CDD:293791 16/34 (47%)
WD40 repeat 180..215 CDD:293791 12/35 (34%)
WD40 repeat 222..263 CDD:293791 12/43 (28%)
WD40 repeat 271..308 CDD:293791 13/38 (34%)
PTZ00121 <376..598 CDD:173412 25/105 (24%)
Blue background indicates that the domain is not in the aligned region.

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