DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CORO7 and pod-1

DIOPT Version :10

Sequence 1:NP_078811.3 Gene:CORO7 / 79585 HGNCID:26161 Length:925 Species:Homo sapiens
Sequence 2:NP_001263735.1 Gene:pod-1 / 176784 WormBaseID:WBGene00004075 Length:1136 Species:Caenorhabditis elegans


Alignment Length:1027 Identity:307/1027 - (29%)
Similarity:490/1027 - (47%) Gaps:166/1027 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     3 RFRVSKFRHTEARPPRRES--------------------------------------------WI 23
            ||..|||::|..:.|::|:                                            .|
 Worm     4 RFAASKFKNTTPKVPKKENEYDDGDEASVEEDHYDDLTSESNNGVGSRRRSRAVSCKIKFNTETI 68

Human    24 SDIRAGTAPSCRNH-IKSSCSLIAFNSD-RPGVLGIVPLQGQGEDKRR-VAHLGCHSDLVTDLDF 85
            .|:..|.. ||.|. |.:|...:||:.: ..|.||::|:..:|...|. :..:..|.:.|.|..|
 Worm    69 FDVPVGNL-SCTNDGIHASADFLAFHIEGEGGKLGVLPITAKGRRTRNDIGIIAAHGEQVADFGF 132

Human    86 SPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTV 150
            ..|.|.||||.|.|..||:|:| ....:...|..:.:|..::..|.|:.|.|:|.||...:..:.
 Worm   133 LTFADELLATCSRDEPVKIWKL-SRDHSPKLATEIDVGGGNVIAECLRAHSTADNILAVGSHGST 196

Human   151 KVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVG-TACKDKQLRIFDPRTKPRASQSTQAHEN-S 213
            .:.|.:..:...||:...|.|||..||.||.|:. :..|.:|:.::|||......|:.:.|.. .
 Worm   197 YITDISTGKTAVELSGVTDKVQSMDWSEDGKLLAVSGDKGRQIVVYDPRASMEPIQTLEGHGGMG 261

Human   214 RDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLA 278
            |::|:.:.|  ..|:||||...|.:||:.:||..:.:.:.:....::.|.|:|..|.|:.|:.|:
 Worm   262 REARVLFAG--NRLISTGFTTKRIQEVRAYDTGKWGAPVHTQEFVSTTGVLIPHYDADTRLVFLS 324

Human   279 GKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGY 343
            |||..:|:..|:..:||.||.|.:..|.....||.:..::.:.||..||....||:.::|||...
 Worm   325 GKGTNKLFMLEMQDRQPYLSHVFELTLPEQTLGATIGAKRRVHVMDGEVDTYYQLTKSSIVPTPC 389

Human   344 HVPRKAV-EFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPL- 406
            .|||::. :||.||||:|.|..|......|..|.|...||||:      .||.:|...||.||: 
 Worm   390 IVPRRSYRDFHSDLFPETRGAEPGCTAGEWLNGTNAVPQKVSM------APSQSSSSPPPPEPVP 448

Human   407 -PDTAQ---------------------------PAVME-------------------------TP 418
             |..||                           |:|.|                         ||
 Worm   449 TPKVAQTPAPVPVPTPAAAPRPMSNNNSSSNNVPSVQEQHSVPKKEEVRELDYRPYEKENGVHTP 513

Human   419 VGDADASEGFSSPPSSLT----------------SPSTPSSLGPS----------------LSST 451
            ..:.::::|.|||.|:::                |.||||.:||:                :.::
 Worm   514 NAETNSTQGNSSPISTISPEPVTIVKPASTPATDSVSTPSVVGPAFGKKVPEQPPVNFRKPIGAS 578

Human   452 SGIGTSPSLRSLQSLLGP-SSKFRHAQGTVLHRDSHI-TNLKGLNLTTPGESDGFCANKLRVAVP 514
            :.:..|..:|....::|. :|||||..|....:...: :||:.:|...|.||:|.|.:....|||
 Worm   579 NRVPLSQRVRPKSCVVGQITSKFRHVDGQQGTKSGAVFSNLRNVNTRLPPESNGVCCSNKFAAVP 643

Human   515 LLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRV----- 574
             |:..|.:.:.::.:||:|||..:..:.|...||||.|:|||..:|||..:..:|.|||:     
 Worm   644 -LAGLGVIGIYDVNEPGKLPDGVMDGIFNKTLVTDLHWNPFDDEQLAVGTDCGQINLWRLTTNDG 707

Human   575 PAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQ 639
            |...:|     ||.::....|||.|||:||||:::||.:..:.|:.:||:.......:...|...
 Worm   708 PRNEME-----PEKIIKIGGEKITSLRWHPLASDLLAVALSNSTIELWDVANAKLYSRFVNHTGG 767

Human   640 IFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPG-PKGGRGARIVWVCDGRCLLVSGFDS 703
            |..:|||.||:::|:|.||..:.|:.|.|..:.:.|... .:..|.||:::.||.|.::|.|...
 Worm   768 ILGIAWSADGRRIASVGKDATLFVHEPASREQRVYERKTVVESTRAARVLFACDDRIVIVVGMTK 832

Human   704 QSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFL 768
            .|:||:.:|:|:.:....:....:|.|...|:|.||.|:.::.|:||||..|.::|::.:||:.|
 Worm   833 SSQRQVQMYDAQTVDLRHIYTQVIDSATQPLVPHYDYDSNVLFLSGKGDRFVNMFEVIYDSPYLL 897

Human   769 ECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAV 833
            ....|.||...:|:....|.:|:|..||...|.||...:||.:.||:||::|:.||||:|||:.|
 Worm   898 PLAPFMSPVGSQGIAFHQKLKCNVMAVEFQVCWRLSDKNLEKITFRVPRIKKDVFQDDLFPDSLV 962

Human   834 IWEPVLSAEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPA----RRAPSSA 881
            .||||.:...|:.|....|...||:|..:  .|..||...|    ...|||:
 Worm   963 TWEPVTTGTKWMLGEQAAPVFRSLKPDGV--FSSIPRAITASVRHSEMPSSS 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CORO7NP_078811.3 WD40 6..428 CDD:475233 142/525 (27%)
WD 1 75..115 16/39 (41%)
WD40 repeat 81..124 CDD:293791 15/42 (36%)
WD 2 124..163 8/38 (21%)
WD40 repeat 129..165 CDD:293791 9/35 (26%)
WD 3 166..205 14/39 (36%)
WD40 repeat 172..208 CDD:293791 13/36 (36%)
WD 4 209..253 14/44 (32%)
WD40 repeat 215..256 CDD:293791 12/40 (30%)
WD40 repeat 263..302 CDD:293791 16/38 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..461 13/73 (18%)
WD40 471..880 CDD:475233 146/419 (35%)
WD40 repeat 504..540 CDD:293791 11/35 (31%)
WD 5 542..582 18/44 (41%)
WD40 repeat 547..591 CDD:293791 19/48 (40%)
WD 6 592..632 15/39 (38%)
WD40 repeat 598..634 CDD:293791 12/35 (34%)
WD 7 635..674 14/38 (37%)
WD40 repeat 640..677 CDD:293791 14/36 (39%)
WD 8 728..768 16/39 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 858..925 8/28 (29%)
pod-1NP_001263735.1 DUF1899 3..111 CDD:462645 22/107 (21%)
WD40 99..>427 CDD:475233 107/330 (32%)
WD40 repeat 175..211 CDD:293791 9/35 (26%)
WD40 repeat 218..255 CDD:293791 13/36 (36%)
WD40 repeat 261..302 CDD:293791 13/42 (31%)
WD40 repeat 309..350 CDD:293791 16/40 (40%)
WD40 599..1029 CDD:475233 148/422 (35%)
WD40 repeat 676..720 CDD:293791 18/48 (38%)
WD40 repeat 725..762 CDD:293791 13/36 (36%)
WD40 repeat 769..809 CDD:293791 13/39 (33%)
WD40 repeat 816..855 CDD:293791 10/38 (26%)
WD40 repeat 863..903 CDD:293791 15/39 (38%)

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