DRSC/TRiP Functional Genomics Resources

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Protein Alignment SPAG16 and PAC1

DIOPT Version :9

Sequence 1:NP_078808.3 Gene:SPAG16 / 79582 HGNCID:23225 Length:631 Species:Homo sapiens
Sequence 2:NP_014912.1 Gene:PAC1 / 854443 SGDID:S000005795 Length:494 Species:Saccharomyces cerevisiae


Alignment Length:520 Identity:101/520 - (19%)
Similarity:176/520 - (33%) Gaps:175/520 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   205 EKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKEKMLT--------SLERDKVV--------- 252
            :||:|  |...|:....:|:.|:|..|.:.:..::..::|        |::|.:.:         
Yeast    14 QKNEL--DKSVLRYLNWNYKQTVRHEHAQDYESVRHAIVTLSGFLLQESVDRQEFISNNDTSNES 76

Human   253 -------------GQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREA----- 299
                         ..|..||:.:.:|::.......|||..:::..|.|...||......|     
Yeast    77 MVDIDELLLPKKWNSIVRLQKKIIELEQNTETLVSQIKDLNTQVSELAQFKPTTSNGTSAHNVLK 141

Human   300 ---REQNKCKTKMKGNTKDSEFPIDMQPN-PNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSM 360
               |....|..    |.:.|...:.:.|| |.:.|:.        |:.....|.|....:...|:
Yeast   142 WIPRNLPSCLI----NVESSVTSVKLHPNLPIVFVAT--------DHGKLYAFDLFNYTIPLASL 194

Human   361 QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTD--------------------WLSDCC---- 401
            |.|...:.|              .:||.|.:.::.                    |:|:.|    
Yeast   195 QSHTKAITS--------------MDVLFTNYTNSSKKNYLVIVTASKDLQIHVFKWVSEECKFQQ 245

Human   402 ----------------FHPSGD-KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN 449
                            :..:.| .:|:.|.|.|||:||...|..:.||:.||:  |..:....|:
Yeast   246 IRSLLGHEHIVSAVKIWQKNNDVHIASCSRDQTVKIWDFHNGWSLKTFQPHSQ--WVRSIDVLGD 308

Human   450 FVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPF---------------------SNTL 493
            ::.|.|.|.|.::....|........||...:..::|..|                     ....
Yeast   309 YIISGSHDTTLRLTHWPSGNGLSVGTGHEFPIEKVKFIHFIEDSPEIRFRTPSTDRYKNWGMQYC 373

Human   494 LTSSADKTLSIWDA--------RTGI---------CEQSLYGHMHSINDAIFDPRGHMIASCDAC 541
            :::|.|:|:.||:.        |..|         |..:|.||:..:.|  ...||..:.||...
Yeast   374 VSASRDRTIKIWEIPLPTLMAHRAPIPNPTDSNFRCVLTLKGHLSWVRD--ISIRGQYLFSCADD 436

Human   542 GVTKLWD---------FRKLLP--IVSIDIGPSPGNEVNFDS--SGRVLAQASGNGVIHLLDLKS 593
            ...:.||         :.||..  :..:|:      :|:|||  :.|.:....|      ||.||
Yeast   437 KSVRCWDLNTGQCLHVWEKLHTGFVNCLDL------DVDFDSNVTPRQMMVTGG------LDCKS 489

Human   594  593
            Yeast   490  489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPAG16NP_078808.3 Prefoldin 160..271 CDD:298833 16/95 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..332 16/74 (22%)
WD40 <341..631 CDD:225201 69/345 (20%)
WD40 344..631 CDD:238121 68/342 (20%)
WD 1 350..389 7/38 (18%)
WD40 repeat 355..392 CDD:293791 7/36 (19%)
WD 2 392..431 13/79 (16%)
WD40 repeat 398..434 CDD:293791 14/56 (25%)
WD 3 434..473 9/38 (24%)
WD40 repeat 439..475 CDD:293791 7/35 (20%)
WD 4 476..515 12/76 (16%)
WD40 repeat 482..516 CDD:293791 10/71 (14%)
WD 5 518..557 11/49 (22%)
WD40 repeat 523..559 CDD:293791 9/46 (20%)
WD 6 560..600 10/36 (28%)
WD40 repeat 565..600 CDD:293791 10/31 (32%)
WD 7 601..630
WD40 repeat 607..630 CDD:293791
PAC1NP_014912.1 WD40 155..492 CDD:238121 74/373 (20%)
WD40 repeat 158..196 CDD:293791 8/45 (18%)
WD40 repeat 202..251 CDD:293791 7/62 (11%)
WD40 repeat 256..294 CDD:293791 11/37 (30%)
WD40 repeat 301..339 CDD:293791 8/37 (22%)
WD40 repeat 346..414 CDD:293791 9/67 (13%)
WD40 repeat 420..458 CDD:293791 9/39 (23%)
WD40 repeat 465..492 CDD:293791 11/37 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0295
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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