DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPAG16 and CG12325

DIOPT Version :9

Sequence 1:	NP_078808.3	Gene:	SPAG16 / 79582	HGNCID:	23225	Length:	631	Species:	Homo sapiens
Sequence 2:	NP_001286296.1	Gene:	CG12325 / 36144	FlyBaseID:	FBgn0033557	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	105/471 - (22%)
Similarity:	160/471 - (33%)	Gaps:	130/471 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   243 LTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAREQNKCKT 307
            |...||.|:.      ....||.::..|.:..:..|::..||:...|..|    :||.:.|..|.
  Fly   225 LEDAERPKIA------PPQRKKEKKAVSDNESEDDVENVVEKDALKEEST----KEAEDVNHIKN 279

Human   308 KMKGNTKDSEF-----------------PIDMQ-PNPNLNVSKESL-----SPAKFDYKLKNIFR 349
              :..||...|                 ..|:| ...|.|...:.|     |.|.:.|:|.::..
  Fly   280 --EDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDVNM 342

Human   350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLT-----------GFGHTDWLSDCCFH 403
            :|.|   .:|..|....|.:|..|  |..|...:...||.           ..||:..::...:.
  Fly   343 IHSL---SISDYPISAALFNCTGD--WVALASREIGQLLVWEWQSEQYIMKQQGHSSEMTCIAYS 402

Human   404 PSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468
            ..|..:||...|:.||||:.....|.:||..|:..|....:.....|:.|||||.|.:.:|||..
  Fly   403 SDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDVNRY 467

Human   469 R--------------CRCTLY------------------------------GHTDSVNSIEFFPF 489
            |              |....|                              ||...|.||.|.|.
  Fly   468 RNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGKLLEIISGHEGPVVSIAFSPV 532

Human   490 --SNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKL 552
              |:||::.|.|||:.||:......|......:..:.:..|.|.|..||.....|...::|.:
  Fly   533 ATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAVATLSGNITIFDIK-- 595

Human   553 LPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIH------KLMGHENEAHTVVF 611
                               |:|:|......|      ||.:|.:.      :.....|...|:.:
  Fly   596 -------------------SAGQVTTIEGRN------DLSAGRLETDIITARKNAQANYFSTIEY 635

Human   612 SHDGEILFSGGSDGTV 627
            |.|||.:.:.|....:
  Fly   636 SADGECILAAGKSANI 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPAG16	NP_078808.3	Prefoldin	160..271	CDD:298833	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..332		17/83 (20%)
		WD40	<341..631	CDD:225201	79/350 (23%)
		WD40	344..631	CDD:238121	78/347 (22%)
		WD 1	350..389		10/38 (26%)
		WD40 repeat	355..392	CDD:293791	9/47 (19%)
		WD 2	392..431		11/38 (29%)
		WD40 repeat	398..434	CDD:293791	11/35 (31%)
		WD 3	434..473		14/52 (27%)
		WD40 repeat	439..475	CDD:293791	13/49 (27%)
		WD 4	476..515		17/40 (43%)
		WD40 repeat	482..516	CDD:293791	14/35 (40%)
		WD 5	518..557		7/38 (18%)
		WD40 repeat	523..559	CDD:293791	7/35 (20%)
		WD 6	560..600		7/45 (16%)
		WD40 repeat	565..600	CDD:293791	7/40 (18%)
		WD 7	601..630		7/27 (26%)
		WD40 repeat	607..630	CDD:293791	6/21 (29%)
CG12325	NP_001286296.1	WD40	16..483	CDD:225201	65/274 (24%)
		WD40	<20..171	CDD:295369
		WD40 repeat	59..94	CDD:293791
		WD40	98..463	CDD:295369	61/254 (24%)
		WD40 repeat	99..143	CDD:293791
		WD40 repeat	149..187	CDD:293791
		WD40 repeat	192..247	CDD:293791	6/27 (22%)
		WD40	<291..681	CDD:225201	86/393 (22%)
		WD40	352..605	CDD:238121	63/275 (23%)
		WD40 repeat	353..391	CDD:293791	7/39 (18%)
		WD40 repeat	397..433	CDD:293791	11/35 (31%)
		WD40 repeat	438..474	CDD:293791	12/35 (34%)
		WD40 repeat	482..518	CDD:293791	2/35 (6%)
		WD40	513..>756	CDD:295369	38/166 (23%)
		WD40 repeat	524..557	CDD:293791	14/32 (44%)
		WD40 repeat	565..594	CDD:293791	6/28 (21%)
		Utp12	794..893	CDD:281932
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910