Protein Alignment CDC73 and CG6220

DIOPT Version :10

• Sequence 1: NP_078805.3
• Gene: CDC73 / 79577
• HGNCID: 16783
• Length: 531
• Species: Homo sapiens
• Sequence 2: NP_610897.1
• Gene: CG6220 / 36520
• FlyBaseID: FBgn0033865
• Length: 359
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 120/396 - (30%)
• Similarity: 190/396 - (47%)
• Gaps: 79/396 - (19%)

Human   170 IRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITAL---KQRSFVDAEVDVTRDIVSRERVW 231
            :::|:|.|:||.||.||||.:|.|:|..|..:  .:.|.   |.|:..:.:.::.|..:.|||..
  Fly     5 LKTLTETMTVEAIAIIKAKRLAMKQSVDKNAM--QMRAQEREKGRNLDNMQKELGRRAMKRERPC 67

Human   232 RTRTTILQSTGKNFSKNIFAILQSVKARE-------------EGRAPE----QRPAPNAAPVDPT 279
            |.           |.:.:....:...|:|             :...||    :.|.|      |.
  Fly    68 RV-----------FEEQLLGEKEMTTAQEYLKLAHHSMMRSLDSTVPELSQLEMPPP------PE 115

Human   280 LRTKQPIP-AAYNRYDQERF-KGKEE----TEGFKIDTMGTYHGMTLKSVTEGASARKTQTPAAQ 338
            :.|:.|.| ..||||.||:| |.::|    .:|..::...|:|        |....::.::.:.:
  Fly   116 IMTEPPWPKTKYNRYGQEKFLKAQQEFGINPQGSNLENCATFH--------ESQKDKRNRSVSRE 172

Human   339 PVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEKKKQGCQ----- 398
            .:.|..|.::...:.|..:|.|||::|.|.||:|::.|.|.||::|.:.|    ::.|.|
  Fly   173 SIERSRSNSKDRRSSKLYARMPIIVVPDAMTSMISLNNIKTLLEELHYEP----ERNGRQSNPPE 233

Human   399 -RENETLIQRR-KDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGPAWQFKGWPWLL 461
             |..|.:::.| ::::          |.|||:|....|.|.:||||||||..||.||||||
  Fly   234 CRPKEVIVEHRFQNEL----------VSYRVIDNVTNLTPVEWDRVVAVFAMGPKWQFKGW---- 284

Human   462 PDGS-PVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKH 525
            |||: |..||.|:.||||.:....:.|.:.|..|..|.||..:||.|..:.:.||..:||:|..|
  Fly   285 PDGADPAAIFHKVCAFHLHFRNTPMCPELTKLQVHSLALSPTERHSDSGIIMEFWNRVDRHMAVH 349

Human   526 KSHLRF 531
            .....|
  Fly   350 ARQFAF 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDC73	NP_078805.3	CDC73_N	1..297	CDD:464994	39/147 (27%)
		Nuclear localization signal	125..139
		Interaction with POLR2A and PAF1	200..531		104/364 (29%)
		Interaction with CTNNB1. /evidence=ECO:0000269|PubMed:16630820	200..250		9/52 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..292		10/49 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..358		4/32 (13%)
		CDC73_C	357..520	CDD:461570	65/170 (38%)
CG6220	NP_610897.1	CDC73_N	<5..134	CDD:464994	39/147 (27%)
		CDC73_C	190..344	CDD:461570	65/171 (38%)