Protein Alignment EPS8L3 and eps8l3

DIOPT Version :9

• Sequence 1: XP_011540434.1
• Gene: EPS8L3 / 79574
• HGNCID: 21297
• Length: 602
• Species: Homo sapiens
• Sequence 2: XP_012817032.1
• Gene: eps8l3 / 548426
• XenbaseID: XB-GENE-982663
• Length: 566
• Species: Xenopus tropicalis
• Alignment Length: 619
• Identity: 233/619 - (37%)
• Similarity: 335/619 - (54%)
• Gaps: 99/619 - (15%)

Human     1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQGRVWS 65
            :|||:::.||..||:|:|:|::..|..|||||||:||.. .:.::..||.|:.|..::||||:|.
 Frog    24 ISRPTAKNIYQQRKQYAQSLSTAVTNFQHRVEHLLTCDL-DKELRNVEDCLKHLSFLEAQGRIWG 87

Human    66 QDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGLPGTSTLLFQ 130
            |.||||:.:|.:.|.|.|||:.|:...|.::...:..|...:|||:|:|.||..  ..||...||
 Frog    88 QGLILQLENGEILLKDPETKDSLEQLPLQNVDNCSSVLGGSTYNSLLTIKVQTQ--QKTSIFFFQ 150

Human   131 CQEVGAERLKTSLQKALEE-------------ELEQSRPRLGGLQPGQD-----RWRGPAMERPL 177
            |.|..|:.|..:|:|||::             .||.|.|:...|:..|.     .|..|.|||
 Frog   151 CDEQPADVLHANLEKALKQFRLNKESKDTYRYNLENSHPQNNFLERSQSPQSSGGWDSPRMER-- 213

Human   178 PMEQARYLEPGIPPEQP-HQRTLEHS-PWSPYTAGLPPSPRPLPRHTSAREPSAFTLPPPRRSSS 240
               |.:|    .|.|.| .||..|.| |..|     |||.:|         |.:|...|   .:|
 Frog   214 ---QPKY----SPRESPIQQRRFELSEPVHP-----PPSTKP---------PPSFQAAP---VNS 254

Human   241 PEDPERDEEVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFN 305
            ..:.|||.|:|||:|.|||||:|||     ...:|||..|       |.:::::||.||.|::|.
 Frog   255 KSETERDIEILNHLLGDIELFVGKL-----NIDKKKKKAK-------LPESEFVDCLQKAKYAFI 307

Human   306 LLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESNL 370
            |:|.:...:|:.|||:|:|::.::|..|:.|||:..|...|:|||||.||:.::.||::..|...
 Frog   308 LMGNVHEQMKQPSAPDLIHLMMETLAKIVDRCPQKDLPQSVLSPLLTQKALMIMSSCVTDKERKF 372

Human   371 WMGLGPAWTTSRADWTGDEPLP-YQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGSTSHFP 434
            |..||.||..:||:|...:.:| |.|||||.|.:|:      :.:.|..|         ..|..|
 Frog   373 WESLGDAWMKTRAEWPNGKNIPQYVPTFSDGWIIPD------IPFSDVSS---------QMSRSP 422

Human   435 QEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVK 499
            :....|....|                |.|.||::|||||.|||:|.:|:.::|||.|::||:|:
 Frog   423 ETPLRNRQFHP----------------LLMNVLHDFEARNNRELSVRKGDIVKVLDQSRQWWMVQ 471

Human   500 NEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLT 564
            |..|:.|:|||||||...      .||:|:...:|..|||||||..|||.:.||..|||.||.|.
 Frog   472 NSQGQQGFIPSNILENTD------DGQAPASSVVLNPSSRPEEVKAWLQQKGFSNITVRCLGVLQ 530

Human   565 GSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 598
            |.|||.:...:|:.:||:|..|:..:|..||..|
 Frog   531 GDQLLELTREDLKTVCPEEGGRVYLQLSTVRGSL 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8L3	XP_011540434.1	PTB_EPS8	25..154	CDD:269921	54/141 (38%)
		SH3_Eps8	464..516	CDD:212698	30/51 (59%)
		SAM_superfamily	533..598	CDD:301707	31/64 (48%)
eps8l3	XP_012817032.1	PTB	51..176	CDD:369863	51/127 (40%)
		SH3_Eps8	435..488	CDD:212698	30/52 (58%)
		SAM_EPS8-like	499..564	CDD:188939	31/64 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I20616
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H15878
Inparanoid	1	1.050	359	1.000	Inparanoid score	I9721
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0009347
OrthoInspector	1	1.000	-	-		oto155401
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11018
SonicParanoid	1	1.000	-	-		X7083
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.090