DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPS8L3 and CG8907

DIOPT Version :9

Sequence 1:	XP_011540434.1	Gene:	EPS8L3 / 79574	HGNCID:	21297	Length:	602	Species:	Homo sapiens
Sequence 2:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	169/724 - (23%)
Similarity:	263/724 - (36%)	Gaps:	229/724 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    23 EPTLLQHRVEHLMTCK-QGSQRVQGPEDALQKLFEMDAQGRVWSQDLILQVRDGWLQLLDIETKE 86
            :||   :.:|||.|.| :....|:.|::.::.|.|::..|.:|...:.:.....||.:||.:.||
  Fly    44 KPT---YALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMKE 105

Human    87 ----------ELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGLPGTSTLLFQCQEVGA----E 137
                      |..::..|..|.        |:|:||..:|....|..|...:||..:|.:    |
  Fly   106 IENFPGSLITEPTAFISDHPQE--------SFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVE 162

Human   138 RLKTSLQKALEEELEQSRPRLGGLQPGQDRWRGPAMERPLPMEQARYLEPGIPPEQP-HQRTLEH 201
            .||| |.|              |.....||.:.|.:   ||           .||:| :|:..:.
  Fly   163 DLKT-LSK--------------GTPVTVDRNKTPIL---LP-----------KPERPQNQQAKDQ 198

Human   202 SPWSPYTAGLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEEVLNHVLRDIELFMGKLE 266
            ...:...||:            |.|.:|.         ..|..|||.:|:||...|||.||.:|.
  Fly   199 YGIAAAVAGI------------AAEKNAI---------DKEQTERDVQVINHCFEDIERFMARLH 242

Human   267 -KAQAKTSRKKKFGKKNKDQGGL--------TQAQYIDCFQKIKHSFNLLGRLATWLKETSAPEL 322
             .|:|....|.:..:.|....||        .::::.|...|.|.:.....||.....:.:.|
  Fly   243 YAAEALNELKLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKPADP-- 305

Human   323 VHILFKSLNFILARC----PEAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRA 383
            ||.:|.||..|:..|    .:|||...|::|||..:.|..|...|...|..||..|||.||..:
  Fly   306 VHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPK- 369

Human   384 DWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDP 448
            |...|....|.|.|.|||. |:......:.|..| :|::      ||:  |........|.||..
  Fly   370 DQFKDHKSSYHPIFYDDWS-PDWVVDEEVPYLAP-ALKK------STT--PSPVPVPMPPSPGLG 424

Human   449 NSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNIL 513
            |....|...::.....:|.:...|.|.:||.|.:||.||::|.|:.||..:|..|..||:|..:|
  Fly   425 NRTWLSRLESRNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVL 489

Human   514 EP--LQPGT----------------------------------------PGTQGQSPSRV----- 531
            .|  .:||.                                        |...|::..|.
  Fly   490 TPYNFEPGVNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPN 554

Human   532 -----PM--------------------------------------------------LRL----- 536
                 ||                                                  |||
  Fly   555 VPVPPPMPPPSDSQTPTPSGTLKRNMAAAGALAAMRARNDCEADDQLYYMQGDVHDELRLLQQQR 619

Human   537 ------------------SSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQ-MLCPQ 582
                              :|:|.||.:||:.:.||...::.|.:|:|.::..:.|..:: ....:
  Fly   620 ERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFGRR 684

Human   583 EAPRILSRL 591
            |:.|::|::
  Fly   685 ESRRLISQI 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPS8L3	XP_011540434.1	PTB_EPS8	25..154	CDD:269921	37/143 (26%)
		SH3_Eps8	464..516	CDD:212698	21/53 (40%)
		SAM_superfamily	533..598	CDD:301707	19/133 (14%)
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	39/156 (25%)
		SH3_Eps8	439..492	CDD:212698	20/52 (38%)
		SAM_superfamily	635..699	CDD:301707	15/59 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151766
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42216
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810