Protein Alignment GCC1 and GCC88

DIOPT Version :10

• Sequence 1: NP_078799.2
• Gene: GCC1 / 79571
• HGNCID: 19095
• Length: 775
• Species: Homo sapiens
• Sequence 2: NP_650055.1
• Gene: GCC88 / 41350
• FlyBaseID: FBgn0037881
• Length: 695
• Species: Drosophila melanogaster
• Alignment Length: 792
• Identity: 236/792 - (29%)
• Similarity: 401/792 - (50%)
• Gaps: 153/792 - (19%)

Human    14 KKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEAD-VGLAGVQLPGL 77
            :::|...:.|||:||.:|:.||||||.|||.|||||||||.|   |:...||. ||.:|
  Fly     5 QRELEALVSTQKEQLGRYEKRLKDVVTAYKGLLKEKEALETS---LAAHAEATAVGESG------ 60

Human    78 TFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSS 142
                       :.:.:.....||.|:|...|          :..|.|||.|.:|
  Fly    61 -----------SPARELESKKTSTDSADGAT----------EGAAPGPPAPPAE----------- 93

Human   143 SSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMK-------QDLEDA 200
                            .||:||:.||.:||||::.||||||||:.||||:::       |.:::.
  Fly    94 ----------------GQLQTQIITLMNSLATLSAEKSRMEASFQADKKQLRSQIAQKEQTIQEL 142

Human   201 SNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLE 265
            :.:|:|:.||.:.:       :.|.||:.|.::.:|.:|.::..||:||||||..:||..:.::|
  Fly   143 NTRAKEQAARAKSD-------VDEIKAKWIVERQEREKETNNQMLMIRELQKLYADERHLKDNIE 200

Human   266 LRLEETREALAGRAYAAEQMEGFELQTKQLTREVEEL--KSELQAIRDEKNQPDPRLQELQEEAA 328
            ::|...:...|.......::...:.|.|:...::::.  |:|..|...........||:::.|..
  Fly   201 MQLNNFKTQFASNEAENSRLRELQSQLKEARSQLKQFQAKTEHSAAASASADSAALLQQVRLEMQ 265

Human   329 RLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQK 393
            :||......::||.|:...||:|.|:|:.:.|.|||:||.:::|:|..:|:|::.:|:||.:|..
  Fly   266 QLKEQHAVAIRQEQRRVLRAEEQSRRQAALHEDRVASLEARLAELSTTVGSYDRLRQQDQDSIHD 330

Human   394 LKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEK 458
            ||:::  .|||.      |..|...:|......:||..|.|:|.:||:||..|..:|...||:.
  Fly   331 LKQQL--QDLEQ------AHVRPTSNSRALNEDVDVATLVDEMVRLKKLLTTANARSANPLDLG- 386

Human   459 LCDLEIMPSSEAADGEKATAL----YYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEA 519
                ||:..|    |:.||.:    :.:|:|:.:::..|..|.:.|:           |.::::.
  Fly   387 ----EILSFS----GQTATRVESHAHCEQQLQGVQQMLEASKQQRQL-----------LEQKVQL 432

Human   520 AQEQLAELKEKYISLRLSCEELEHQHQQEADD----WKQELARLQQLHRQELE---RCQLDFRDR 577
            ....:..|:||...|..:.:|.|.:.:|:.:.    .|.|..:.|:. :.|||   ||:|:
  Fly   433 QHSHIQTLQEKVQVLNRNIDEAEVELKQQGEKLRLALKNERTKWQEA-KAELENETRCKLN---- 492

Human   578 TLKLEEELHKQRDRALAVLTEKDLELEQLRS----VALASGLPGRRSPVGGGGPGDP-----AD- 632
              :||:.|.|||.|:|.:|.||:.|::.|::    ...|||:        |.....|     ||
  Fly   493 --ELEQLLQKQRQRSLQLLDEKEQEIKTLQTSFEVFHSASGV--------GSTLATPTLEAAADS 547

Human   633 ---TSSSDSL----------TQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQ- 683
               :|.:||:          .::.:::.........||.:||||::|||:|||.|:..|..:.:
  Fly   548 FHYSSDTDSVEGEQRERKLKVRSKKMSMGENCHMLHYANELARKDIEITTLRKAKYAAESTLRKA 612

Human   684 LQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAILT 748
            :||::..:.|.| |::..|:..:::..|.::|||||||||||:|..::...|:.|::..|.||..
  Fly   613 IQDKVTSQQEMH-EKIECLKEQVDRLERCKTREGANLEYLKNVIISYIVTRDADGKRHMLNAISA 676

Human   749 ILHFSPEEKQVI 760
            :|.|:..|.|.|
  Fly   677 VLQFTAAEMQAI 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCC1	NP_078799.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..153		11/68 (16%)
		Smc	<153..>608	CDD:440809	140/474 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..639		7/33 (21%)
		GRIP	717..760	CDD:460221	19/42 (45%)
		GRIP domain	719..760		17/40 (43%)
GCC88	NP_650055.1	Smc	<33..>341	CDD:440809	112/379 (30%)
		SMC_prok_B	219..>527	CDD:274008	94/342 (27%)
		GRIP	645..688	CDD:460221	19/42 (45%)