DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EPM2A and CG10089

DIOPT Version :9

Sequence 1:	NP_005661.1	Gene:	EPM2A / 7957	HGNCID:	3413	Length:	331	Species:	Homo sapiens
Sequence 2:	NP_001261803.1	Gene:	CG10089 / 39517	FlyBaseID:	FBgn0036369	Length:	447	Species:	Drosophila melanogaster

Alignment Length:	174	Identity:	39/174 - (22%)
Similarity:	70/174 - (40%)	Gaps:	44/174 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   156 HYSRILPNIWLGSCPRQVEHVTI---KLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTM 217
            |..::||.:::|:.....:|..:   |:.|.:.|                   :..|..:.||
  Fly     4 HMGKVLPGLYVGNYRDSKDHAQLERFKISHIIAI-------------------HDSPRRLLPD-- 47

Human   218 IKLYREEGLAYIWMPTPDMSTEGRVQMLPQ--AVC--LLHAL-LEKGHIVYVHCNAGVGRSTAAV 277
             |.|    |..:...|||       |.|.|  :||  .:||. |.:|::: :||.||:.||....
  Fly    48 -KHY----LCVMASDTPD-------QNLSQYFSVCNDFIHAARLREGNVL-IHCLAGMSRSVTVA 99

Human   278 CGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKF 321
            ..::......|.::....:.|.|.....:....::.||  |::|
  Fly   100 VAYIMTATHLNWKEALKVVRAGRAVANPNAGFQSQLQE--FEQF 141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPM2A	NP_005661.1	CBM20_laforin	1..129	CDD:99881
		Substrate binding. /evidence=ECO:0000269\|PubMed:25544560, ECO:0007744\|PDB:4RKK	103..107
		PTPc	158..304	CDD:304379	34/153 (22%)
		Glucan phosphatase signature motif CXAGXGR. /evidence=ECO:0000305\|PubMed:25544560, ECO:0000305\|PubMed:26231210	266..272		3/5 (60%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:25544560, ECO:0007744\|PDB:4RKK	267..272		2/4 (50%)
CG10089	NP_001261803.1	DSPc	4..139	CDD:238073	37/170 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900